EvE Bio
@EvEBiotech
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Durham NC nonprofit biotechnology start-up working to map the pharmome. Nurtured by @Convergent_FROs, supported by generous philanthropists.
Durham, NC
Joined March 2023
Exciting to see EvE Bio's ever-expanding pharmome mapping dataset ( cited as a source of training/test data for @FutureHouseSF's ether0 LLM, a new scientific reasoning model for chemistry. Their preprint is here:
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EvE Bio's public data release #4:.1.4k Rx drugs vs 24 new potential off-targets including adrenergic, apelin, muscarinic, dopamine, gastrin-releasing, orexin, 5-HT, neuromedin, opioid, prostaglandin, sphingosine, somatostatin & neuromedin receptors.
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Wake up, babe. EvE Bio's data release #4 just dropped. 1.4k Rx drugs, 85 targets (and counting).237k mode/target/compound combos.8 median agonists per target (< 1 uM).31 median antagonists per target (< 1uM). Browse or DL (for non-commercial use) at
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Come work with us in Durham, NC!. EvE Bio's Assay Dev team seeks a pharmacology scientist to develop new cell-based screening assays. This is a temp position (filling in for a scientist on family leave) with potential to become permanent.
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RT @KumarAGarg: 1/ UPDATE: I'm so excited to announce our newest program: the Big if True Science Accelerator (BiTS). The goal is help mo….
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Our data release #3, now live at adds 7 new nuclear receptors + 14 new 7TMs to our ever-growing list of human gene products screened against 1.4K FDA-approved drugs to ID off-targets, train AIs, repurpose drugs, and more. Enjoy!
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EvE Data Release 2 now live!. 1.4K drugs' activities at 21 7TMs including.ADRA2A.ADRA2B .ADRA2C .ADRB1.ADRB2.DRD1.DRD2.GAL1.GAL2.GHSR.HRH1.HRH3.HRH4.HTR1A.HTR1B.HTR1D.HTR1F.HTR2A.HTR5.HTR6.PTH1R.in ag & antag modes.
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Are you a molecular or synthetic biologist, with molecular biology & mammalian cell culture skills, living in NC's Research Triangle region (extra points if you're experienced in drug development/discovery in academia or industry)?. Let's talk! 🧪.
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Why? Because you can't have a rational discussion while locked in Skinner box.
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🧪 Not an EvE Bio production, but uses our recent Data Release 1 data. Very cool to gain a peek into how others' minds approach dataviz surrounding our work. Open data unleashes enormous creativity. .
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RT @AdamMarblestone: @EvEBiotech OK have to be done being nerd-sniped till their next data drop :-)..
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RT @andrewwhite01: Here's a little drawing of the some of the 1400 compounds released in @EvEBiotech's first data dump. .
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RT @AdamMarblestone: @EvEBiotech Smart Young Folks, .Hope you can make better visualizations than this notebook I whipped up..
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We're honored to find EvE Bio's efforts cited alongside heavy hitters like Protein Data Bank and Align to Innovate in 's new playbook on philanthropic support for mid-scale science efforts in open datasets and benchmarks. Thank you, @RenPhil21!
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RT @tkalil2050: 1/ Today, @RenPhil published our first set of playbooks for leveraging philanthropy and innovation to solve important probl….
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🧪 Back when we were collecting voice-of-customer advice for EvE Bio, the single best advice we received was "Just put all of your data up on the web and smart young folks will instantly start analyzing the bejeebers out of it.". Bejeeber #1 just dropped. Congrats, Aaron!.
This is so cool - 5 mins in RStudio + Claude = analysis of which receptors all of the medications I'm taking (ant)agonize, potentially leading to non priced-in effects. I just want MORE (receptors mostly, also drugs)
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Excited to announce Data Release 1, profiling 1,400 small-molecule FDA-approved drugs vs. an ultimately vast # of gene products. This 1st release is a shake-down cruise, so limited to select nuclear receptors. More to come. Browse, download, enjoy!
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Part 2 in our series of reasons to map the pharmome: to catalog drug repurposing opportunities.
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