Eli Rosenbaum
@Elirosenbaum11
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GU oncologist @RabinMedical_ #prostatecancer #bladdercancer #kidneycancer #testicularcancer
Joined September 2022
PFS of course.
Until we have OS results, positive DFS alone is not a surprise since a third active drug was added. Only if the DFS of the triplet is better than ipi+nivo followed by Cabo, it would be a meaningful result and only if significant enough it maybe worth the added toxicity #ESMO22.
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Until we have OS results, positive DFS alone is not a surprise since a third active drug was added. Only if the DFS of the triplet is better than ipi+nivo followed by Cabo, it would be a meaningful result and only if significant enough it maybe worth the added toxicity #ESMO22.
Cabozantinib/ipilimumab/nivolumab triplet hits DFS primary endpoint (vs ipi/nivo). RR 43% +CR 3% are modest. 32% increase in G3/4 toxicity may be explanation. Benefit seem ⬆️ in intermediate risk pts. OS is going to be important for things to significantly change #ESMO22
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As was proved in the STAPEDE, 2 years of ADT and abiraterone with XRT can cure high risk localised PCa (probably also by curing micrometastasis). A subgroup of these salvage XRT patients (who still need to be identified), may need not only longer ADT but also the addition of Abi.
Great presentations. More ADT reduces metastatic recurrence but less treatment fine for majority of patients with no OS differences. Need more data to identify who benefits and who needs less therapy.
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