Lindsey A Ramirez, PhD
@Dr_Ramirez_
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#FirstGen w PhD who wants to make science accessible and inclusive because we are stronger together than we are against each other.
Georgia, USA
Joined October 2018
Stop by the last set of posters today to complete your @glover_lab bingo card! @JackieRSanchez @HeyHyerimYang @RSAposts #RSA2024
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Don't lose steam yet! Stop by these @glover_lab posters this afternoon! @KarlNeuro @RSAposts #rsa2024
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The @glover_lab has poster presentations everyday at RSA! Please come say hi and learn about our work. Shikun is our first presenter.
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This was a huge team effort! Thank you to the other authors @Przy_PhD , Joseph R. Pitock, E Margaret Starr, @HeyHyerimYang and to everyone who contributed to this project. I couldn’t have done this without the mentorship of the @glover_lab and the support of the @CareUic. 🧵10
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Our data suggest that the neural circuits involved in signaling aversion are disrupted by CIE. We look forward to studying these circuits in the future.🧵9
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These results were unexpected. We did not see tolerance to the aversive properties in the CIE group like we originally thought. Instead, we see incubation of CTA in the AIR controls that is disrupted by CIE.🧵8
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We wanted to see how this CTA would change following two weeks of chronic intermittent ethanol exposure (CIE). While AIR controls had an increase in CTA magnitude, this was attenuated by CIE in most ethanol groups. 🧵7
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Similarly, all females that had saccharin paired with ethanol developed CTA 🧵6
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All males that had saccharin paired with ethanol developed CTA 🧵5
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We created a paradigm that avoids pre-exposure to ethanol and that allows us to compare the same rats across different time points. Male and female Long-Evans rats underwent these procedures. 🧵4
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We use conditioned taste aversion (CTA) to measure the aversive properties of ethanol. The animal learns to associate the taste of saccharin with the aversive experience of injected ethanol. Exposure to one of these stimuli without the other hinders the association.🧵3
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The aversive properties of ethanol limit ethanol intake. However clinical evidence suggests that people chronically exposed to ethanol develop tolerance to the aversive properties, losing their protection against drinking.🧵2
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I’m so excited to share my first published work from my postdoc lab, @glover_lab . Let me tell you more about it! 🧵 https://t.co/8O8WPEvgdY
#AlcoholResearch #NeuroTwitter
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These results were unexpected. We did not see tolerance to the aversive properties in the CIE group like we originally thought. Instead, we saw incubation of CTA in the AIR controls that is disrupted by CIE. 🧵8
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We wanted to see how this CTA would change following two weeks of chronic intermittent ethanol exposure (CIE). While AIR controls had an increase in CTA magnitude, this was attenuated by CIE in most ethanol groups. 🧵7
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Similarly, all females that had saccharin paired with ethanol developed CTA. 🧵6
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All males that had saccharin paired with ethanol developed CTA. 🧵5
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We created a paradigm that avoids pre-exposure to ethanol and that allows us to compare the same rats across different time points. Male and female Long-Evans rats underwent these procedures. 🧵4
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