Brendan Nolan
@DrBrendanNolan1
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#Endocrinologist & #transhealth researcher. @unimelbMDHS 🤓🏳️⚧️ He/him.
Brisbane, Queensland
Joined March 2021
New Research: Approach to prolactin monitoring and hyperprolactinaemia in transgender and gender-diverse individuals undergoing gender affirming hormone therapy https://t.co/1vw4GKVVxZ
#FrontiersIn #Endocrinology
frontiersin.org
Transgender and gender-diverse (herein, trans) individuals who desire feminisation are typically treated with estradiol and an anti-androgen such as spironol...
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🔥 Review: "Laboratory Monitoring in #Transgender and Gender-Diverse Individuals" by Brendan J Nolan & Ada S Cheung @UnimelbMDHS
@DrAdaCheungAU
@DrBrendanNolan1 👉 https://t.co/wHSHJofFlN
#PathTwitter #LabMedX #MedTwitter
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Key findings: ✅ 46% of individuals achieved serum estradiol within the target range of Australian guidelines. ✅ Median serum estradiol was 396 pmol/L on 1.5 mg (2 pumps) daily. EstroGel represents a safe alternative first-line option for gender-affirming hormone therapy.
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Our recent study explored EstroGel (estradiol 0.06% gel) use in trans and gender-diverse adults 🏳️⚧️ https://t.co/lz2YcfoJEn
@DrAdaCheungAU
onlinelibrary.wiley.com
Objective Transgender and gender-diverse individuals undergoing estradiol therapy for gender affirmation are typically treated with oral or transdermal estradiol, with transdermal estradiol recomme...
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@DrAdaCheungAU We suggest that treating clinicians should provide this information by using the corresponding gender marker on laboratory requests or provide relevant history to ensure the appropriate laboratory reference ranges are reported.
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@DrAdaCheungAU Once individuals have commenced GAHT, in general, the reference range of the affirmed gender should be reported for laboratory tests with sex-specific reference intervals (including haemoglobin/haematocrit and creatinine).
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@DrAdaCheungAU With increasing numbers of trans people seeking gender affirming hormone therapy (GAHT), it is important that clinicians, pathologists, and laboratory scientists use appropriate reference ranges.
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New 🏳️⚧️ publication with @DrAdaCheungAU Laboratory Monitoring in Transgender and Gender-Diverse Individuals 🔬 https://t.co/HqbRUBj4jr
academic.oup.com
AbstractBackground. Increasing numbers of transgender and gender-diverse individuals are seeking initiation of gender-affirming hormone therapy. This align
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@DrAdaCheungAU Reassuringly, median ALT (a liver enzyme) remained within the normal range.
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@DrAdaCheungAU In 24 individuals treated with bicalutamide, we report significant variation in serum total testosterone concentration, likely related to concomitant estradiol or previous anti-androgen therapy.
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New 🏳️⚧️ publication: There is interest in use of bicalutamide as antiandrogen therapy for trans people treated with estradiol-based hormone therapy. We report our experience with bicalutamide: https://t.co/nUaApfxwpL
#transhealth #transresearch @DrAdaCheungAU
journals.sagepub.com
Background: There is interest in repurposing bicalutamide for gender-affirming hormone therapy, but little data regarding efficacy and safety in the transgender...
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Secondary analysis of our RCT: early access to #testosterone therapy is linked to improved self-reported health in #transgender and gender-diverse adults seeking masculinization 🏳️⚧️ #transresearch #transhealth @DrBrendanNolan1 @SavZwickl @UniMelbMDHS
https://t.co/JKHBrXdSsK
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Our previous manuscript can be found here ➡️ 10.1001/jamanetworkopen.2023.31919 We found that early access to testosterone decreases gender dysphoria, produces clinically significant reductions in depression, and a 50% reduction in thoughts of suicide/self-harm in trans adults
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Further research is needed to determine the optimal quality of life tool in the trans population
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In a secondary analysis of our RCT, early access to testosterone improved self-reported health (measured via EQ-VAS) in trans adults 🏳️⚧️ 10.1001/jamanetworkopen.2024.43466 #transhealth #transresearch #transgender #transmen #nonbinary
@DrAdaCheungAU @SavZwickl @UniMelbMDHS
This secondary analysis of an RCT finds that early access to testosterone therapy is linked to improved self-reported health in transgender and gender-diverse adults seeking masculinization.
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So proud of our symposium yesterday at @wpath on psychosocial and social health outcomes after gender-affirming hormones. Amazing presentations from @NessaMillet1 @HormonoGo from @AffirmRelation and @DrBrendanNolan1. This work is so important to healthcare equity for trans people
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@DrAdaCheungAU @SavZwickl We call for an authority indication for "gender affirmation" to gain an accurate assessment of the number of trans people treated with testosterone in Australia.
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In a recent analysis, we found that over half of subsidised testosterone prescriptions for people under 40 years are likely for trans people 🏳️⚧️#transhealth #transgender @DrAdaCheungAU @SavZwickl
onlinelibrary.wiley.com
Click on the article title to read more.
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There are many #endocrinologists 🩺 who don't feel confident treating #trans people. @DrBrendanNolan1's latest review aims to make that easier 🏳️⚧️ #transhealth #transgender
onlinelibrary.wiley.com
Gender-affirming hormone therapy (GAHT) is used by many transgender and gender-diverse adults to align physical characteristics with their gender identity, reduce gender incongruence and improve...
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🏳️🌈Most nonbinary people taking testosterone therapy for gender affirmation continue to take lower doses than recommended guidelines at 1 year. Read more ⬇️ @DrBrendanNolan1 @TheEndoSociety #ENDO2024
https://t.co/LzIN7MOMqW
healio.com
BOSTON — Most nonbinary people who initiated low-dose transdermal testosterone for gender affirmation continued taking doses that were lower than current guideline recommendations at 1 year, resear...
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