Doc Edge
@DocEdge85
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Assistant professor in quantitative and computational biology @USC. Genetics, evolution, and a bit of statistics.
Joined November 2015
RT @pastramimachine: latest paper from the lab led by PhD student Gilia Patterson. Gilia has developed a spatially explicit deep learning m….
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RT @biorxiv_genetic: Mutation-selection-drift balance models of complex diseases #biorxiv_genetic.
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RT @biorxiv_evobio: When should adaptation arise from a polygenic response versus few large effect changes? #biorxi….
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RT @baym: I went on WBUR today to talk about the grant terminations and the importance of basic medical research.
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RT @baym: In the right conditions, antibiotic resistance can happen extremely fast. Here is an example from my own work of bacteria overcom….
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RT @baym: This entire line of research, after being repeatedly selected in rigorous open national competitions for funding, was cut this we….
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RT @SashaGusevPosts: Hanania advocated passionately against "race mixing" for years, so he knows what he's talking about here. But it's wor….
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RT @GeneticsGSA: In population #GENETICS, Q-ST and F-ST calculations help compare the amount of trait differentiation on one or more traits….
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RT @GeneticsGSA: In a new #GENETICS research, @Dandan_Peng, Mulder, and @DocEdge85 evaluate the performance of several ancestral recombinat….
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RT @janisl98: My paper about type I error rates in Qst/Fst comparisons is now published in @GeneticsGSA. Check it out here: .
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RT @GregorGorjanc: VERY excited to announce a pre-print that represents the culmination of several years of work*: “On ARGs, pedigrees, and….
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RT @nmancuso_: Excited to see this out! Fast, powerful methods for single cell mapping using count based models.
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Our daughter's wonderful teacher and her family lost everything in the Eaton fire. If you can spare a few dollars to help out, I would be grateful
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RT @mariaakop: 1/7 🧬 New Preprint Alert: Our study highlights the risks of using divergent reference genomes in population genomics. The ch….
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RT @jkpritch: In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox: .For many traits the number of duplications or….
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University of Superabundant Coaches.
BREAKING: USC football has been placed on probation by the NCAA for exceeding the permissible number of countable coaches in 2022 and 2023, the Los Angeles Times reported Tuesday morning. The University was fined $50,000.
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For many more simulations and a detailed explanation, see Janis's new preprint (10/10).
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Every result we see is well explained by viewing both Qst and Fst in terms of coalescent theory (9/n).
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Further, we find (in line with previous work) that the version of Fst used (Nei's or Weir & Cockerham) has to be compatible with the version of Qst used (8/n).
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Another example: it's common to use the distribution of single-locus Fsts as a null, but Janis finds that this only works well for polygenic traits if one limits to single-locus Fst for common variants. Using rarer mutations can send Type I error very high (7/n)
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