Kedar Inamdar
@Doc2020Heme
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Staff Hematopathologist, Henry Ford Hospital, Detroit, MI, USA Opinions are my own
Detroit, MI, USA
Joined December 2020
More on rare presentations of APL➡️ APL with circulating myeloblasts, and "aleukemic" promyelocytes confined to the marrow may cause diagnostic challenges: If diagnosis relied only on peripheral blood findings, the promyelocytic component hidden in the marrow may be missed,
Acute promyelocytic leukemia (APL) in the setting of primary or secondary MPO deficiency can create diagnostic challenges, as bright MPO expression by flow cytometry analysis is a key feature of APL. Six cases of APL with reduced MPO expression (2 cases) and absent MPO
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Acute promyelocytic leukemia (APL) in the setting of primary or secondary MPO deficiency can create diagnostic challenges, as bright MPO expression by flow cytometry analysis is a key feature of APL. Six cases of APL with reduced MPO expression (2 cases) and absent MPO
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A new fear unlocked: Leukemic non-nodal mantle cell lymphoma may involve the bone marrow in a very subtle sinusoidal way, as illustrated in figure 1 below with H&E and CCND1 stain highlighting a sinusoidal neoplastic lymphocytic infiltrate. In addition to this sneaky pattern of
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4 the young #pathologists here, who may not know: angiomyofibroblastoma, retiform hemangioendothelioma, spindle cell liposarcoma, cellular angiofibroma, soft tissue angiofibroma, etc were among many entities recognized & described by Dr. Fletcher (& trainees) Give him a shoutout
What horrible news. What a huge loss to the #pathology community. 💔 Chris Fletcher was and will always be among the most brilliant, visionary and influential pathologists of all time. May his incredible legacy live long through his trainees and students.
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This can be very confusing so don’t call them neoplastic #MedTwitter #PathTwitter
Would you recognize BCMA CAR T cells if they came across your desk/screen? Check out this article from the Journal of Hematopathology from @Michael_Kallen_ and colleagues https://t.co/Q6mqnYlpVw
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📄Analysis of 222 CCUS cases confirmed the comparable mutational spectrum between #CCUS and #MDS, reflecting the biological continuum. However, significant variations were observed in both the frequency and VAF of specific gene mutations:
nature.com
Leukemia - Genomic landscape of CCUS compared to MDS and its implications on risk prediction
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Follicular lymphoma with abundant extracellular eosinophilic material, mimicking amyloid deposition: An unsual variant to be aware of #hemepath #lymsm #pathtwitter #MedEd #SoMe Check a similar but more prominent case by @sanamloghavi @BloodJournal➡️ https://t.co/FgGDXEZwZw
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Mark the date! October 4-8, 2024. Internal Clinical Cytometry Society Annual Meeting, Seattle, Washington. #FlowICCS24
Save the Date! The ICCS 2024 Annual Meeting and Course will take place October 4-8, 2024 in Seattle, Washington. @ICCS_Education @iccsWic
https://t.co/BXw4HP26aE
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Pathologists, beware that Kikuchi can mimic T cell lymphoma! Be careful. #pathology #hemepath #pathtwitter
https://t.co/Pf2Z5HNDHZ
onlinelibrary.wiley.com
Kikuchi disease with exuberant T-cell proliferation mimicking T-cell lymphoma: Histologically, sheets of large cells are present associated with karyorrhectic debris. Immunophenotypically, large...
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we have come such a long way in our understanding of IgG4-related disease. This is a volume of seminars in diagnostic pathology devoted to Ig4-related disease. Covers virtually every organ. written by Folks that have spent their careers writing about this disease. The focus is
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We know about Stage 1, 2 & 3 hematogones, but Stage 0 hematogones? Read all about this CD19-negative population and the implications for MRD testing in patients receiving anti-CD19 therapies, in this pathbreaking paper just published in Clinical Cytometry! https://t.co/1T7JEFbsRd
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#Hemepath pitfall alert! Thrombopoietin-mimetic agents such as eltrombopag (Promacta) & romiplostim (Nplate) cause changes in megakaryocytes that exactly mimic MDS/MPNs. The paper below describes some abnormal forms, but I've seen the whole gamut. Be wary! https://t.co/C9Jjq1gvMo
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An example of EBV-negative extra-nodal marginal zone lymphoma (ENMZL), involving the lung, 6 years post transplant PTLDs occurring later after the first year of transplantation, are more frequently EBV-negative. The late PTLDs are also more commonly monomorphic Mutations
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Relapsed DLBCL with unusual spindle-cell morphology, reminiscent of follicular dendritic cell sarcoma (FDCS), with diffuse aberrant expression of FDC markers CD21 and CD23 #hemepath #lymsm #surgpath #pathtwitter #pathX #MedTwitter #MedX #MedEd
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To be or not to be… is there such a thing as type G LyP? Am J Surg Pathol, 2024 Lymphomatoid Papulosis With T-cell Receptor-Gamma Delta Expression: A Clinicopathologic Case-series of 26 Patients of an Underrecognized Immunophenotypic Variant of Lymphomatoid Papulosis
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The WHO Classification of Haematolymphoid Tumours, 5th edition, is now finalized 👏😊 and is available on-line at https://t.co/c1bweKYbJV It will soon be available as a two volume printed book. #hemepath #lymphoma #WHO
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Are you a pathology trainee interested in a #hemepath fellowship? Big news: most hemepath fellowship programs will be moving to a match process for positions that begin in 2026! For more information: https://t.co/2WFaouRS8t
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Out today in @ModernPathology B- ALL, T-ALL, MPAL , myeloid/lymphoid neoplasms with eosinophilia and defining gene rearrangements, histiocytic and dendritic neoplasms #hemepath
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