Dityatev Lab
@DityatevL
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The mission of #Molecular #Neuroplasticity group is to study the functions of #extracellular #matrix (ECM) in healthy adult #brain and in major brain disorders
Magdeburg, Germany
Joined February 2016
Overview of our research on neural extracellular matrix (ECM) and perineuronal nets (PNNs)
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A collaborative study with the group of Ildiko Dunay on "Reduced synaptic tagging by complement protein C3 is associated with elevated extracellular matrix in the middle-aged cerebellum of mice" is available online:
frontiersin.org
BackgroundAging of the brain is associated with cognitive decline and recognized as a major risk factor for the development of neurodegenerative diseases. On...
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Our article in Alzheimer's & Dementia on treatment of tauopathies received enough views to be a Top Viewed Article - #TopViewedArticle @wileyinresearch.
alz-journals.onlinelibrary.wiley.com
INTRODUCTION Hyperphosphorylation and aggregation of the microtubule-associated protein tau cause the development of tauopathies, such as Alzheimer's disease and frontotemporal dementia (FTD). We...
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Astrocyte-derived MMP-9 is a key mediator of pseudorabies virus penetration of the blood-brain barrier and tight junction disruption
pubmed.ncbi.nlm.nih.gov
Pseudorabies virus (PRV) infection leads to viral encephalitis and neurological damage in mice, causing significant neurological symptoms and brain damage. This study aimed to investigate the...
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This year, there were two symposia on ECM at the German Society for Neuroscience. A lot of new data was shown, such a memorable event!
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A preprint of our new study showing that Short Polysialic Acid Counteracts Age-Related Synaptic and Cognitive Deficits is available in BioRxiv:
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Dr. Carla Cangalaya from our group got Marie Skłodowska-Curie postdoctoral fellowship to move for 2 years to Dr. Christos Gkogkas lab at the Foundation for Research and Technology (FORTH) in Greece and study synaptic pruning by microglia in neurodevelopmental diseases.
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Matrix metalloproteinases accelerate pericellular matrix breakdown and disrupt mechanotransduction in osteoarthritis
pubmed.ncbi.nlm.nih.gov
The pericellular matrix (PCM) is a specialized, narrow matrix surrounding each chondrocyte in articular cartilage, together constituting the chondron - the fundamental metabolic and functional unit...
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A new study from our group is online: Partial microglial depletion improves synaptic plasticity and cognitive performance in aged mice
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Pro-cognitive reshaping of neuronal dynamics by a human CSF-based factor
pubmed.ncbi.nlm.nih.gov
Neuronal connection dysfunction is a convergent cause of cognitive deficits in mental disorders. Cognitive processes are finely regulated at the synaptic level by membrane proteins, some of which are...
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Matrix Biology published our study on "Neurocan regulates axon initial segment organization and neuronal activity"
pubmed.ncbi.nlm.nih.gov
The neural extracellular matrix (ECM) accumulates in the form of perineuronal nets (PNNs), particularly around fast-spiking GABAergic interneurons in the cortex and hippocampus, but also around...
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Disruption of extracellular matrix and perineuronal nets modulates extracellular space volume and geometry
pubmed.ncbi.nlm.nih.gov
Extracellular matrix (ECM) is a network of macromolecules which has two forms-perineuronal nets (PNNs) and a diffuse ECM (dECM)-both influence brain development, synapse formation, neuroplasticity,...
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Adolescent cerebellar nuclei manipulation alters reversal learning and perineuronal net intensity
pubmed.ncbi.nlm.nih.gov
The cerebellum, identified to be active during cognitive and social behavior, has multisynaptic connections through the cerebellar nuclei (CN) and thalamus to cortical regions, yet formation and...
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FN1 and VEGFA Are Potential Therapeutic Targets in Glioblastoma as Determined by Bioinformatics Analysis
pubmed.ncbi.nlm.nih.gov
This study suggests that high levels of FN1 and VEGFA expression are associated with a poor prognosis in glioblastoma and that both genes are promising targets for glioblastoma therapy. Bioinformat...
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Eleven clinical trials that will shape medicine in 2025
nature.com
Nature Medicine - Nature Medicine asks leading researchers to name their top clinical trial for 2025, from gene therapies for prion disease and sickle-cell disease to digital tools for cancer and...
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Macrophages producing chondroitin sulfate proteoglycan-4 induce neuro-cardiac junction impairment in Duchenne muscular dystrophy
pubmed.ncbi.nlm.nih.gov
Duchenne muscular dystrophy (DMD) is caused by the absence of the full form of the dystrophin protein, which is essential for maintaining the structural integrity of muscle cells, including those in...
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Microglia phagocytosis of PNNs mediates PV-positive interneuron dysfunction and associated gamma oscillations in neuroinflammation induced model of cognitive impairment in mice
pubmed.ncbi.nlm.nih.gov
Neuroinflammation, characterized by activation of glial cells, plays a critical role in central nervous system disorders. However, the precise mechanisms of neuroinflammation contributing to cognit...
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Extracellular matrix integrity regulates GABAergic plasticity in the hippocampus
pubmed.ncbi.nlm.nih.gov
The brain's extracellular matrix (ECM) is crucial for neural circuit functionality, synaptic plasticity, and learning. While the role of the ECM in excitatory synapses has been extensively studied,...
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Increased levels of extracellular matrix proteins associated with extracellular vesicles from brains of aged mice
pubmed.ncbi.nlm.nih.gov
Extracellular vesicles (EVs) are secreted by all major cell types of the brain, providing a mode of intercellular communication and a pathway for disposal of cellular debris. EVs help maintain...
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RT @DityatevL: @NatureNV highlights the obesity mechanisms driven by a build-up of molecular mesh around hunger neurons .
nature.com
Nature - Neuronal insulin resistance caused by excess extracellular matrix.
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RT @RohanKrajeski: @JoshDoesNeuro's article exposes how the brain's extracellular matrix (ECM)—a massive 20% of its volume—is the hidden ke….
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