Deyasini Chakraborty
@Deyasini_C
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PhD, Thomä lab @LabThoma at Friedrich Miescher Institute for Biomedical Research @FMIscience. Interested in chromatin biology.
Basel, Switzerland
Joined October 2019
Excited to share that we got selected for the @MolecularCell Cover for the latest issue released today! Congratulations @Sandate_C !.
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RT @IrinaBezsonova: New drawing!.Ubiquitin-specific protease 7 (pdb 4M5W).It’s been a while since I last drew anything. Forgot how fun it i….
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@Sandate_C @LabThoma Big shoutout to the FMI Structural Biology platform - Simone Cavadini, Lukas Kater and Georg Kempf, and the amazing scientific environment provided by the FMI Basel @FMIscience.
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Special thanks to co-author Colby Sandate @Sandate_C .for joining the p53 team and to all the contributing authors and the members of @LabThoma .Grateful to Nico for supporting this project and the fruitful collaboration with the Schübeler lab.
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3. Additionally, we resolved high-resolution cryo-EM structures of E6AP-E6-p53 ternary complex showing multiple oligomeric states. 4. We further showed that USP7 remains functional in a chromatinised context.
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2. We reported the first cryo-EM structure of cofactor-TF (USP7-p53) complex on nucleosome.
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We discovered that nucleosomes play a decisive role in determining the interacting partners of p53. 1. DUB USP7 forms a nucleosome-bound complex with p53 while human papilloma virus protein, E6 in complex with E3-ubiquitin ligase E6AP cannot do so.
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Excited to share that my first-author publication on the interplay of p53 with cofactors on chromatin is now online in @MolecularCell : Nucleosomes filter cofactor access to p53 - USP7 binds whereas E6AP-E6 fails to form a complex.
cell.com
Chakraborty, Sandate, et al. report that chromatin-bound p53 interacts with deubiquitinating enzyme USP7 but not with the E3 ubiquitin ligase E6AP-E6, despite both co-factors being associated with...
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RT @FMIscience: Our cells pack DNA into tiny bundles that hide important parts. Researchers at FMI and @EPFL found this packing affects how….
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Excited to announce that I defended my PhD thesis on Monday!! Huge thanks to @FMIscience! Special thanks to my supervisor Nico (@LabThoma) and the members of my thesis committee, Dirk (@SchubelerLab) and Seth Rubin for all the support over the years!.
Congratulations to Dr. Deyasini Chakraborty on defending her PhD thesis this week! 🥳🎓 Her research reveals how nucleosomes—structures of DNA wrapped around proteins—control the access of specific molecules to p53, a protein that helps regulate cell growth and prevent cancer.
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RT @RPNowak: We can now activate p53 Y220C by recruiting BRD4 to it with small molecule TRAP-1. This was a great collaboration with Gray la….
biorxiv.org
TP53 is the most commonly mutated gene in cancer, but it remains recalcitrant to clinically meaningful therapeutic reactivation. We present here the discovery and characterization of a small molecule...
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RT @LukeIsbel: Exciting Masters/PhD opportunities in Adelaide Australia, balancing creativity, excellence and inclusion!! Please join if yo….
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RT @FMIscience: Huge congratulations to Francesca Masoni on successfully defending her PhD thesis yesterday! Francesca worked towards bette….
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RT @lisastoos_: I'm excited to share that I received a poster prize at the EMBL Transcription and Chromatin conference! Grateful for the op….
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Congratulations @aliciakmichael 🥳🎉 looking forward to the work from your lab!.
Feeling very honored to receive #ERCStG #ChromaChrono ⏱️🧬alongside fantastic colleagues & excited to launch this next chapter @ISTAustria together with my new team @Edgyonkar @_dariaspires @DeepthiJoseph7 and others to come! A big thank you to all those for their support!.
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RT @SchubelerLab: Wouldn’t it be great to test how individual transcription factors engage with their motif in the nucleus? We tried exactl….
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RT @LabThoma: Check out our latest review on Pioneer Transcription Factors (TFs) by @_M_Carminati, Luca Vecchia, and @lisastoos_ in Current….
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RT @FMIscience: Last week, more than 220 FMIers and a handful of colleagues from Novartis got together in Davos for three intense days of n….
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A month has already passed since I had the opportunity to present a part of my PhD project at the Cold Spring Harbor - Mechanisms of Eukaryotic Transcription Conference 2023. It was an exciting experience, and would thank the organisers for the amazing event.#cshlmoet @lisastoos_
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