David Sinclair
@davidasinclair
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Professor @Harvard researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own 🙏✌️
Boston
Joined March 2012
Statistically, you should not exist: – Life-friendly universe: 1/10⁶⁰ – Earth + moon: 1/10⁹ – Multicellular life: 1/10⁴ – Intelligence & civilization: 1/10⁹ – Your genome: 1/70 trillion You’ve already won the lottery 10 times in a row. Ignore small people & enjoy!
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Stay tuned for a resveratrol study from my lab that addresses the key scientific questions about resveratrol that critics have raised, 10 years in the making...
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Trials are needed. For those doing the studies, it's important for res to be solubilized in food or a carrier. Even some of the mouse lifespan studies were done incorrectly. While rapamycin was carefully formulated by the group, resveratrol wasn't (and you can bet they didn't ask
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The efficacy of resveratrol in the treatment of liver fibrosis: a systematic review and meta-analysis of preclinical studies https://t.co/Oq5MEERLNz
frontiersin.org
ObjectiveTo evaluate the effects and underlying mechanisms of resveratrol—a plant-derived polyphenol abundantly found in natural dietary sources such as grap...
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Statistically, you should not exist: – Life-friendly universe: 1/10⁶⁰ – Earth + moon: 1/10⁹ – Multicellular life: 1/10⁴ – Intelligence & civilization: 1/10⁹ – Your genome: 1/70 trillion You’ve already won the lottery 10 times in a row. Ignore small people & enjoy!
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Guessing the exact order of a shuffled 52-card deck and then getting 47 heads coin flips
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Picking one exact atom out of the entire observable universe
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Equivalent odds: winning the Powerball jackpot 10 times in a row
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Accelerating activity in the longevity sector, writes Michael Ringel @lifebiosciences @NatureAging
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💯
Aging will be remembered as humanity’s greatest disease
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Give us a bit more time
Humanity May Achieve the Singularity Within the Next 3 Months, Scientists Suggest Predictions across the field range from a few months to a few decades, but experts agree: change is coming. https://t.co/JepOd3zC2G
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the singularity is nearest
Humanity May Achieve the Singularity Within the Next 3 Months, Scientists Suggest Predictions across the field range from a few months to a few decades, but experts agree: change is coming. https://t.co/JepOd3zC2G
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This is alarming. Over 60% of VC money is now going to AI companies. For reference, only 40% of the VC money went to internet companies in 1999. If those AI companies don’t start generating real revenue soon enough, investors will start stepping back. When this happens, all
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5 advances in medicine this week 1. One-and-done cholesterol therapy This is an epigenetic editor of PCSK9 — to silence its expression with a one-off dose and lower cholesterol (here in macaques) This complements existing phase 1 human data from Verve Therapeutics for a
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Well deserved 👏 Nobel is awarded for the 1990’s discovery of regulatory T cells, a new type of white blood cell🥇
BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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In what other profession are you bombarded by requests to do free work for profitable companies? Only in academia! How did we get here? 🧵
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