Contreras Group at UT
@Contreras_Lab
Followers
691
Following
275
Media
93
Statuses
282
Finding novel approaches to understand and design RNAs, RNA-protein complexes, and regulatory roles in cellular toxicity and stress-response. Grad managed acct.
University of Texas at Austin
Joined February 2015
Getting the 1st structural & biochemical view of how this enzyme interacts with its oxidized RNA has been exciting work for our lab, led by my student @lucasg_miller in collaboration with @Resendizlab, @ZhangLab_UT , @CSSBatUT & Phanourios Tamamis (Texas A&M). #whatstartshere 🤘🏾.
Stressed about diseases and aging?. @UTAustin engineers have discovered insights into an enzyme, polynucleotide phosphorylase (PNPase), that helps protect cells from oxidative stress, a condition linked to sources like air pollution and cigarette smoke.
0
4
6
Poetry in science? Check out this cool story detailing our recent collaboration with renowned poet @christianbok and lab alumni @TCordovaBio where we engineered the extremophile, Deinococcus radiodurans, to encode a poem!. Link 👉
cockrell.utexas.edu
Texas Engineer Lydia Contreras and Christian Bok encoded poetry into a "deathless bacterium using synthetic biotechnology.
0
1
4
(2/2) uncovering the coordinated efforts of nucleoid-associated proteins, transcription factors, and sRNAs. We also uncovered and validated 5 transcription factors that regulate nutrient-responsive sRNAs.
0
0
0
(1/2) Check out our latest publication in NAR led by lab alumni, @Alyssa_Ekdahl : ! This work captured the global transcriptional regulation of E. coli in response to nutrient stress, . .
academic.oup.com
Abstract. Recent research has indicated the presence of highly protein occupied, transcriptionally silent regions of bacterial genomes which show functiona
1
0
1
(2/2) programmable gene repression! Check it out here: #WhatStartsHere.
biorxiv.org
Deinococcus radiodurans is a highly radiation-resistant extremophile with potential for biomanufacturing and bioremediation in harsh environments, including extraterrestrial settings. However,...
0
0
0
(1/2) We are excited to announce our latest preprint, led by @TCordovaBio and @TrevorRSimmons:.We present a standardized genetic toolkit for engineering in the extremophile Deinococcus radiodurans, enabling tunable gene expression, efficient genome engineering, and (. )
1
0
2
Please join our lab in congratulating Dr. Antonio Cordova (@TCordovaBio)! Today Antonio successfully defended his thesis on developing novel synbio tools within the extremophile D. radiodurans!
0
0
6
Just wrapped up another amazing STEM Girl Day @UTAustin! Our strawberry DNA extraction workshop gave students hands-on experience with real scientific techniques. Seeing young minds light up while discovering biology fundamentals made the day special! @UTWiSTEM #UTSTEMGirlDay 🤘🏾
0
0
8
What an honor to work with @FUTURUMCareers on one of their recent videos, "Decoding RNA mysteries". This animation is a free educational resource aimed at inspiring the next generation of minds in STEM & SHAPE! Check it out! #whatstartshere 🤘🏾
0
3
8
Congratulations to our Lab Member, Ryan Buchser, for his 1st Place finish in the @ProcterGamble Graduate Student Poster Competition this week! Ryan competed with 10 of the best and brightest graduate students from across @UTAustin. Well done, Ryan! #whatstartshere🤘🏾
0
0
7
RT @CockrellSchool: Stressed about diseases and aging?. @UTAustin engineers have discovered insights into an enzyme, polynucleotide phospho….
0
3
0
We are excited to share our most recent publication, led by @lucasg_miller - wherein we use structural & biochemical techniques to uncover the site of 8-oxo-rG recognition by polynucleotide phosphorylase & its impacts in-vitro & in-vivo! #whatstartshere 🤘🏾
pnas.org
RNA oxidation, predominantly through the accumulation of 8-oxo-7,8-dihydroguanosine (8-oxo-rG), represents an important biomarker for cellular oxid...
0
6
25
RT @JudeM_Phillip: Exciting day in the Phillip lab. There is such a special feeling to see your first PhD student successfully defend thei….
0
7
0
We thrilled to share our latest work in @NatureComms, led by @TrevorRSimmons, in which we rewired CsrA to build designer post-transcriptional genetic circuits. Our approach supports the idea of co-opting native networks for complex bacterial computation.
nature.com
Nature Communications - As synthetic biology expands, creating “drag-and-drop” regulatory tools that can achieve diverse regulatory outcomes are paramount. In this work, the Carbon...
1
9
36
We are excited to share our latest preprint, led by @matsuri_rojano & @TrevorRSimmons, in which we identify concentration dependent regulation of CsrA on a novel mRNA target and repurpose this interaction to build a genetic BANDPASS Filter. #WhatStartsHere
0
6
21
RT @FUTURUMCareers: As #chemical #engineer Prof Lydia Contreras (@Contreras_Lab, @UTAustin, @theNASEM) highlights, everyone belongs in #sci….
0
1
0
This article was produced by Futurum Careers, a free online resource & magazine aimed at encouraging 14-19-y/o's worldwide to pursue careers in science, technology, engineering, maths & medicine (STEM), & social sciences, humanities & the arts for people & the economy (SHAPE).
1
0
1
Big thanks to @FUTURUMCareers for featuring Lydia in their latest article: "Decoding RNA mysteries: a new era for biology and medicine"!! We are excited to be at the forefront of scientific innovation in the field of RNA biology. #whatstartshere 🤘🏾 .
futurumcareers.com
Discover the huge range of careers available in RNA biology and learn how scientists are advancing our understanding of RNA modifications
1
1
7
Our recent work with the @FreddolinoLab investigates the complex transcriptional regulation in E. coli during glucose and amino acid starvation. We uncover novel stress responsive chromatin-like structures, alongside transcription factor controlled sRNAs.
biorxiv.org
Recent research has indicated the presence of heterochromatin-like regions of extended protein occupancy and transcriptional silencing of bacterial genomes. We utilized an integrative approach to...
0
4
11