Contreras Group at UT
@Contreras_Lab
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Finding novel approaches to understand and design RNAs, RNA-protein complexes, and regulatory roles in cellular toxicity and stress-response. Grad managed acct.
University of Texas at Austin
Joined February 2015
Getting the 1st structural & biochemical view of how this enzyme interacts with its oxidized RNA has been exciting work for our lab, led by my student @lucasg_miller in collaboration with @Resendizlab, @ZhangLab_UT , @CSSBatUT & Phanourios Tamamis (Texas A&M). #whatstartshere 🤘🏾
Stressed about diseases and aging? @UTAustin engineers have discovered insights into an enzyme, polynucleotide phosphorylase (PNPase), that helps protect cells from oxidative stress, a condition linked to sources like air pollution and cigarette smoke.
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Our very own Agata Turula (@AgataTurula) showcased some of her awesome work on sRNA discovery in the human pathogen, B. pertussis, at the @TexasChE Grad Student Success Celebration late last week!
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Poetry in science? Check out this cool story detailing our recent collaboration with renowned poet @christianbok and lab alumni @TCordovaBio where we engineered the extremophile, Deinococcus radiodurans, to encode a poem! Link 👉
cockrell.utexas.edu
Texas Engineer Lydia Contreras and Christian Bok encoded poetry into a "deathless bacterium using synthetic biotechnology.
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(2/2) uncovering the coordinated efforts of nucleoid-associated proteins, transcription factors, and sRNAs. We also uncovered and validated 5 transcription factors that regulate nutrient-responsive sRNAs.
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(1/2) Check out our latest publication in NAR led by lab alumni, @Alyssa_Ekdahl : https://t.co/5CmyNBrPnl ! This work captured the global transcriptional regulation of E. coli in response to nutrient stress, ...
academic.oup.com
Abstract. Recent research has indicated the presence of highly protein occupied, transcriptionally silent regions of bacterial genomes which show functiona
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(2/2) programmable gene repression! Check it out here: https://t.co/oVbJ86Ebre
#WhatStartsHere
biorxiv.org
Deinococcus radiodurans is a highly radiation-resistant extremophile with potential for biomanufacturing and bioremediation in harsh environments, including extraterrestrial settings. However,...
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(1/2) We are excited to announce our latest preprint, led by @TCordovaBio and @TrevorRSimmons: We present a standardized genetic toolkit for engineering in the extremophile Deinococcus radiodurans, enabling tunable gene expression, efficient genome engineering, and (...)
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Please join our lab in congratulating Dr. Antonio Cordova (@TCordovaBio)! Today Antonio successfully defended his thesis on developing novel synbio tools within the extremophile D. radiodurans!
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Just wrapped up another amazing STEM Girl Day @UTAustin! Our strawberry DNA extraction workshop gave students hands-on experience with real scientific techniques. Seeing young minds light up while discovering biology fundamentals made the day special! @UTWiSTEM #UTSTEMGirlDay 🤘🏾
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What an honor to work with @FUTURUMCareers on one of their recent videos, "Decoding RNA mysteries". This animation is a free educational resource aimed at inspiring the next generation of minds in STEM & SHAPE! Check it out! #whatstartshere 🤘🏾 https://t.co/ZuSVjjM8mV
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Congratulations to our Lab Member, Ryan Buchser, for his 1st Place finish in the @ProcterGamble Graduate Student Poster Competition this week! Ryan competed with 10 of the best and brightest graduate students from across @UTAustin. Well done, Ryan! #whatstartshere🤘🏾
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Stressed about diseases and aging? @UTAustin engineers have discovered insights into an enzyme, polynucleotide phosphorylase (PNPase), that helps protect cells from oxidative stress, a condition linked to sources like air pollution and cigarette smoke.
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We are excited to share our most recent publication, led by @lucasg_miller - wherein we use structural & biochemical techniques to uncover the site of 8-oxo-rG recognition by polynucleotide phosphorylase & its impacts in-vitro & in-vivo! #whatstartshere 🤘🏾 https://t.co/8EjSSlcnXs
pnas.org
RNA oxidation, predominantly through the accumulation of 8-oxo-7,8-dihydroguanosine (8-oxo-rG), represents an important biomarker for cellular oxid...
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Exciting day in the Phillip lab. There is such a special feeling to see your first PhD student successfully defend their Thesis 😁. Introducing Dr. Pratik Kamat. He did an absolutely amazing job. I am so proud of him! 👏👏👏
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We thrilled to share our latest work in @NatureComms, led by @TrevorRSimmons, in which we rewired CsrA to build designer post-transcriptional genetic circuits. Our approach supports the idea of co-opting native networks for complex bacterial computation.
nature.com
Nature Communications - As synthetic biology expands, creating “drag-and-drop” regulatory tools that can achieve diverse regulatory outcomes are paramount. In this work, the Carbon...
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We are excited to share our latest preprint, led by @matsuri_rojano & @TrevorRSimmons, in which we identify concentration dependent regulation of CsrA on a novel mRNA target and repurpose this interaction to build a genetic BANDPASS Filter. https://t.co/j2wGfAI4nK
#WhatStartsHere
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As #chemical #engineer Prof Lydia Contreras (@Contreras_Lab, @UTAustin, @theNASEM) highlights, everyone belongs in #science. Where will you find connections and community in science? https://t.co/lVDDsO88aj
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For more information, see the @FUTURUMCareers website:
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This article was produced by Futurum Careers, a free online resource & magazine aimed at encouraging 14-19-y/o's worldwide to pursue careers in science, technology, engineering, maths & medicine (STEM), & social sciences, humanities & the arts for people & the economy (SHAPE).
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Big thanks to @FUTURUMCareers for featuring Lydia in their latest article: "Decoding RNA mysteries: a new era for biology and medicine"!! We are excited to be at the forefront of scientific innovation in the field of RNA biology. #whatstartshere 🤘🏾 https://t.co/zBeHXjTaA8
futurumcareers.com
Discover the huge range of careers available in RNA biology and learn how scientists are advancing our understanding of RNA modifications
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