Colecraft Lab
@ColecraftL
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(1/10) Happy to share a new story from my lab & Henry Colecraft’s group (@ColecraftL)! We present a novel divalent nanobody (DiVa) approach developed in the Colecraft lab to target specific ion channels for degradation. Read on for more details (and a sprinkling of #cryoEM!) ⬇️
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Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies
biorxiv.org
Targeted recruitment of E3 ubiquitin ligases to degrade traditionally undruggable proteins is a disruptive paradigm for developing new therapeutics. Two salient limitations are that <2% of the ~600...
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Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies https://t.co/b4eL01x39H
#bioRxiv
biorxiv.org
Targeted recruitment of E3 ubiquitin ligases to degrade traditionally undruggable proteins is a disruptive paradigm for developing new therapeutics. Two salient limitations are that <2% of the ~600...
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In this chapter, Sergej Borowik & Henry M. Colecraft @ColumbiaMed provide a comprehensive overview of the role of the Cavβ subunit in the regulation of #calcium #ionchannels, its pathophysiological implication, and its potential as therapeutic target ➡️ https://t.co/r5eT6zPS8U
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Happy to share our latest work published in @NatureComms. Thanks to collaborators @ElectrosomeUCSF and Roger A. Bannister. @ColumbiaPHY @ColumbiaMed Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a…
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Targeted ubiquitination of sensory neuron calcium channels reduces the development of neuropathic pain
pnas.org
Neuropathic pain caused by lesions to somatosensory neurons due to injury or disease is a widespread public health problem that is inadequately man...
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