Cody Loy
@CodyLoy45
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4th Year PhD Student🧪Targeting the Proteasome: Beyond Inhibition @DJTraderLab🧫 @UCIrvine 🏳️🌈
Joined April 2014
RT @UCI_SPPS: A UCI-led research team analyzed the potential of a protein degradation mechanism as a resolution to a long-standing issue in….
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RT @benitezja: ByeTAC: Bypassing E-Ligase-Targeting Chimeras for Direct Proteasome Degradation | Journal of Medicinal Chemistry https://t.c….
pubs.acs.org
The development of targeted protein degradation by recruiting a protein of interest to a ubiquitin ligase to facilitate its degradation has become a powerful therapeutic tool. The potential of this...
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RT @Middleland_er: ByeTAC: Bypassing E-Ligase-Targeting Chimeras for Direct Proteasome Degradation | Journal of Medicinal Chemistry https:/….
pubs.acs.org
The development of targeted protein degradation by recruiting a protein of interest to a ubiquitin ligase to facilitate its degradation has become a powerful therapeutic tool. The potential of this...
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RT @LJSeabrook: So excited that ByeTAC is now out!! Major congrats to @CodyLoy45 and @DJTraderLab 🥳🥳
pubs.acs.org
The development of targeted protein degradation by recruiting a protein of interest to a ubiquitin ligase to facilitate its degradation has become a powerful therapeutic tool. The potential of this...
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RT @Glaconde34: ByeTAC: Bypassing E-Ligase-Targeting Chimeras for Direct Proteasome Degradation | Journal of Medicinal Chemistry https://t.….
pubs.acs.org
The development of targeted protein degradation by recruiting a protein of interest to a ubiquitin ligase to facilitate its degradation has become a powerful therapeutic tool. The potential of this...
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RT @Glaconde34: Immunoproteasome as a Target for Prodrugs | Journal of Medicinal Chemistry
pubs.acs.org
Immunoproteasome (iCP) is a proteasome isoform that is expressed under inflammatory conditions such as cytokine interferon-γ exposure. The iCP has different catalytic subunits other than the standard...
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RT @LJSeabrook: Honored to have our image on the cover of this month’s issue @nchembio featuring the MrTAC paper (linked below)! 🔬🧫 https:/….
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RT @UCI_SPPS: UCI's Albrecht and Trader labs have developed a groundbreaking protein degradation tool called MrTAC (Methylarginine Targetin….
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RT @SaayakH: Check out our recent work-.Synthesis and Application of a Versatile Immunoproteasome Activity Probe no….
chemistry-europe.onlinelibrary.wiley.com
The ONX-0914-alkyne probe described here allows for the conjugation to a variety of fluorophores through click chemistry. It can then be used to visualize immunoproteasome activity in gel-based,...
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RT @LJSeabrook: I’m so excited to welcome MrTAC to the world of targeted protein degradation! We created a chemical inducer of arginine met….
nature.com
Nature Chemical Biology - Development of a targeted protein degradation platform, methylarginine targeting chimera (MrTAC), enables arginine methylation-driven degradation of intracellular proteins...
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Always fun developing new tools to monitor immunoproteasome activity! Check out our latest probe paper 🔭🧪.
Congrats Cody and Saayak on your immunoproteasome probe paper!.
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RT @DJTraderLab: Congrats @CodyLoy45 on your RSC ChemBio paper on a caged luciferin probe for the immunoproteasome!.
pubs.rsc.org
The immunoproteasome (iCP) can be expressed under inflammatory conditions, such as exposure to interferon-gamma (IFN-γ), that alerts the cell to begin generating iCP preferentially over the standard...
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RT @DJTraderLab: Congrats @CodyLoy45 on your recent review on the proteasome's primed substrate channel!.
mdpi.com
Protein homeostasis is a tightly conserved process that is regulated through the ubiquitin proteasome system (UPS) in a ubiquitin-independent or ubiquitin-dependent manner. Over the past two decades,...
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Had an amazing experience at my first Bioorganic Chemistry GRC! From the exciting talks to making some incredible friendships, I can’t wait to go back to science summer camp. 🧪🏕️ Oh, and winning an outstanding poster award wasn’t too bad either!
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Everybody look out, I’ve advanced to PhD candidate status!🍾 😎.
congrats Candidate/Mentor @CodyLoy45 💅🙏.
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Had an amazing experience @janeliaconf and got to learn some really exciting chemical biology! Thank you for the opportunity to share some of my recent work and meet some excellent scientists 🧫🧪.
Thank you to everyone joining us @HHMIJanelia for the third iteration of our Chemical Tools for Complex Biological Systems meeting. #chembio #cellsignaling #imaging #cellbio #biochemistry
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Super excited to be selected for the SPPS PhD Student Spotlight! Check it out here 🧪 @UCI_SPPS @DJTraderLab . PhD Student Spotlight: Research Opportunities Through the Trader Lab Brought Cody Loy to UC Irvine from Purdue University
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Really late sharing this, but super excited for my first paper from @DJTraderLab! 🧫 Check out the discovery of TCL-1 a new ligand for the proteasome subunit Rpn-13. Can’t wait for many more to come!
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RT @DJTraderLab: Excited to get this preprint out!. ByeTAC: Bypassing an E3 Ligase for Targeted Protein Degradation
biorxiv.org
Targeted protein degradation utilizing a bifunctional molecule to initiate ubiquitination and subsequent degradation by the 26S proteasome has been shown to be a powerful therapeutic intervention....
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