Clarisa Marie
@ClarisaMarieMed
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#ARVO2024 As always, after so much learning, discussing, hugging, laughing, and coffee ☕️, it’s time to say bye. See you next year @ARVOinfo in Salt Lake City! @LeeRetinaLab @USCEye
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MicroRNAs cargo of extracellular vesicle #EV is regulated before being secreated from RPE cells! Another step forward to ocular EV therapeutics. @LeeRetinaLab
Dynamics of MicroRNA Secreted via Extracellular Vesicles During the Maturation of Embryonic Stem Cell-Derived Retinal Pigment Epithelium https://t.co/NFmYkHKlZa
#biorxiv_molbio
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Watch out, ophthalmology community! @ClarisaMarieMed is on her way!
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Thanks for all the support Dr. Lee! 😄
@ClarisaMarieMed made our day today receiving the Oliver Goldsmith scholarship 💰AND the best podium award at her school. But what really got us was seeing her choose bench research with little experience. It took many hours of driving coming to the lab and trouble shooting!
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My mentor is so talented!! 💖👁️
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Had an early morning flight to SF for #AAO2023! A little sleepy 😅 but so excited for the weekend!
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#YOs! Want to get more involved working abroad? This year’s second annual #Global #Ophthalmology Summit shows what can happen when young #trainees come together to enhance #eyecare around the world #YOInfo
aao.org
The Global Ophthalmology Summit in Atlanta brought together a diverse spectrum, from seasoned experts with decades of experience to young ophthalmologists at the early stages of their careers. Here ar
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Dr. Sun Young Lee accepted into the Emerging Vision Scientist Program in Washington D.C. @LeeRetinaLab @RPB_org
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Low quality photo, high quality people 📸 So proud to have been a finalist in the inaugural #hackathon at @aao_ophth's Global Ophthalmology Summit this past weekend! I had the absolute BEST time sharing space with people who firmly believe in #EyeHealthForAll 🌎👁 #gosummit2023
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I will be presenting a poster on Saturday titled "Assessing gender bias in readability of ChatGPT responses to ophthalmic questions." See you there!
Come learn about the latest work your peers are doing! With over 500 posters this year, there is an abundance of cutting edge research and fascinating case studies to explore. #WhyWIO #WIO2023 #womeninophthalmology
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@Cells_MDPI @LeeRetinaLab @USCEye @KeckMedUSC 8/8 TLDR: ✅Intravitreally injected exosomes can quickly penetrate full-thickness retina. ✅Systemically injected exosomes can cross the blood-retina barrier. Clinicians, how might you hope to integrate this tech into your future practice? 🧐 #ophthalmology #RetinalDisease
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@Cells_MDPI @LeeRetinaLab @USCEye @KeckMedUSC 7/8 Remarkably, retinal sections obtained just 3h after systemic injxn showed the presence of #exosomes in the retina (D)! This finding suggests that #exosomes have the ability to overcome the blood-retina barrier, opening up new avenues for non-invasive delivery methods 🥳
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@Cells_MDPI @LeeRetinaLab 6/8 But what about exosomes injected systemically? Can they cross the protective BRB? @LeeRetinaLab explored this question by injecting PKH-26-labeled exosomes into the bloodstream via the tail vein. What do you think they saw? @USCEye @KeckMedUSC
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@Cells_MDPI @LeeRetinaLab 5/8 In C, retinal sections 24h after #intravitreal injxn of exosomes (red dots with yellow circles) show that #exosomes were taken up by both the inner and outer #retina, opening up ✨exciting possibilities✨ for targeted delivery of therapeutic cargo to specific retinal cells!
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@Cells_MDPI @LeeRetinaLab 4/8 In A&B, in vivo retinal imaging microscopy performed at 3&24h and retina flat-mounts obtained 1d and 1w after intravitreal injection of PKH-26-labeled exosomes (orange-red) show immediate retinal penetration and wide distribution of intravitreally delivered exosomes. 💉🟠🔴
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@Cells_MDPI @LeeRetinaLab 3/8 Check out Figure 2 from the paper, which provides fascinating insights into the retinal uptake of intravitreally (within the eye) delivered #exosomes and the blood-retina barrier (BRB) crossing of systemically (via the bloodstream) delivered exosomes! 📚🔬
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2/8 Today, I will dive into the paper titled "Intraocular RGD-Engineered Exosomes and Active Targeting of Choroidal Neovascularization (CNV)" published in @Cells_MDPI by @LeeRetinaLab. Let's unravel one of the key takeaways, shall we? 🔬✨ Read here ➡️ https://t.co/J3xTFPdnEB
pmc.ncbi.nlm.nih.gov
Purpose: To assess the transretinal penetration of intravitreally injected retinal multicell-derived exosomes and to develop exosome-based active targeting of choroidal neovascularization (CNV) by...
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