Baron Chanda
@ChandaLab06
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Ion Channel Biophysicist. Loves greasy proteins. Fluorescence spectroscopy, Single molecule dynamics, Electrophysiology, Thermodynamics.
St. Louis, MO, USA
Joined January 2019
Our DeFrND approach is finally published. A simple trick to isolate membrane proteins with native lipids for structural and functional characterization.
nature.com
Nature Communications - To bypass the limitations of detergents, Ren et al. developed peptide scaffolds that extract membrane proteins directly into lipid nanodiscs, preserving the native...
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Our latest Excelsior awardee!! Congratulations, Jessica!
We are delighted to announce that Dr. Jessica Caldwell @JLCaldwellPhD has received the 2025 SGP Excelsior Award! Dr. Caldwell vividly exemplifies the mission of our Society and the future of physiology and biophysics. Learn more https://t.co/Jwyhaqht1p.
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Tickets to the 12th JGP-SGP Mixer are going fast! Join us in LA to connect with fellow SGP members. There is no charge to attend, but you must be an SGP member and register at https://t.co/hnDgu9j3IH. To join SGP, please visit https://t.co/oEpddRbd8X.
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SGP congratulates Dr. Huanghe Yang on receiving the 2025 Paul F. Cranefield Award for his outstanding paper, “Niclosamide potentiates TMEM16A and induces vasoconstriction” https://t.co/Z21VWvCk0B
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SGP congratulates Dr. Man Si on receiving the 2025 Cranefield Postdoctoral Fellow Award for her outstanding paper, “Epilepsy-associated Kv1.1 channel subunits regulate intrinsic cardiac pacemaking in mice” https://t.co/x3nyfXiSKZ
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SGP congratulates Dr. Rachael Lucero on receiving the 2025 Cranefield Student Award for her outstanding paper, “Transport of metformin metabolites by guanidinium exporters of the small multidrug resistance family” https://t.co/e0gX7tSVmK
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2) This work not only advances our understanding of HCN channel modulation but also lays the groundwork for developing isoform-specific analogs of propofol as targeted analgesics. A huge thank you to the talented team of collaborators. @AlexEversLab @veburts @johncowgill11
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1) Excited to share our latest research uncovering a novel conformation-specific binding site for propofol in the voltage sensor domain (VSD) of HCN1 ion channels. https://t.co/avnw8NQsQS
science.org
Propofol inhibits pain by binding to a specific site on HCN channels, offering insights for developing nonsedative treatments.
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Happy to introduce DeFrND: designer peptide scaffolds to enable detergent-free reconstitution of membrane proteins with native lipids into nanodiscs for biochemical and structural studies. Let me know if you would like to try it. https://t.co/DhxKsIXUGE
biorxiv.org
Membrane scaffold proteins-based nanodiscs (NDs) have facilitated unprecedented structural and biophysical analysis of membrane proteins in a near-native lipid environment. However, successful...
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Fortunate to live in a country that understood this more than anyone else...
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Jon Lorsch's blog post: “One major barrier to entry into new markets is the requirement to see the future with clarity. It has been said that to foretell the future, one has to invent it. To be able to invent the future is the dividend that basic research pays.” Wong 1996
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Just 3 weeks until SGP 2024! You can still submit an abstract to present a poster if you🚨submit and register by 15 August at https://t.co/4f6Vtsu7wR🚨Join us to hear great talks by Rachelle Gaudet @RachelleGaudet, Josefina del Mármol @MarmolJosefina, and many more!
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One of the unforgettable moments at the 2024 Ion Channels GRC was the closing lecture by Fred Sigworth. If you missed it, here it is..
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A timely meeting focused on molecular evolution of membrane receptors!
🚨Register for the 77th @sgpweb Meeting🚨, ⭐️"Molecular Evolution in the Membrane: Ion Channels, Transporters, and Receptors"⭐️ Want to be considered for a short talk? Submit your abstract by 🗓️1 August! For more info and to register, visit https://t.co/4f6VtsuFmp.
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There are other interesting structural changes associated with hyperpolarization-dependent opening and future studies will hopefully shed more light on the role of these structural transitions on channel gating.
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Perhaps the most unexpected feature of the structure is the helix-coil transition at the electromechanical coupling interface. Coincidentally, in the dark ages, before we had any structures of ion channels, such a model for voltage-dependent activation was considered!!
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After the first dataset obtained four years ago, it was clear that this was going to be an interesting as well as challenging project! Fantastic team effort led by @veburts @JonathanMount6. Special shoutout to @YuanLabSinai and Jianhan Chen lab at UMass.
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Structures of channels in Open conformation are rare. Thrilled to share our latest manuscript.. Structural basis for hyperpolarization-dependent opening of human HCN1 channel
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Our manuscript in BJ's Rick Aldrich Festschrift issue is now online. Congrats to @JennaLLin @johncowgill11 @DebanjanTewari and Yongchang. Mapping the contribution of the C-linker domain to gating polarity in CNBD channels: Biophysical Journal
cell.com
Ion channels of the cyclic nucleotide-binding domain (CNBD) family play a crucial role in the regulation of key biological processes, such as photoreception and pacemaking activity in the heart....
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Mighty proud of you, Jenna! Congratulations!!
Jenna Lin, a graduate student in the @ChandaLab06, received the prestigious 2024 John E. Majors Award for her outstanding accomplishments in research and teaching! Congratulations, Jenna!
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