Hiroshi
@Cell_Tokyo_Tech
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Work on knock-in mice expressing a histone modification probe (mintbody) was published. Mouse lines were generated by Jun Ueda and Kazuo Yamagata (> 10 yrs ago) and the analysis were done by Yuko Sato, Maoko Takenoshita, and Miku Ueoka. Congratulations! https://t.co/bFoxvRQebH
link.springer.com
Histochemistry and Cell Biology - During development and differentiation, histone modifications dynamically change locally and globally, associated with transcriptional regulation, DNA replication...
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A preprint reporting knock-in mice expressing histone H4K20me1-mintbody, by Yuko Sato and former students, in collaboration with Jun Ueda and Kazuo Yamagata. https://t.co/jMIvgepamd
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Congratulations Martino and Nadine!
It’s finally out! The PhD work and first first author paper of @MartinoUgolini: https://t.co/tm5MSGQkOA. Congrats to all co-authors @mkierun, @lanoliin, Hiroshi Kimura, and Haruka Oda for the beautiful work! We also thank @cSabrya @NatureCellBio for the pleasant review process.
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Work by Naoki Goto (@Naoki_Goto_), a PhD student, about histone H3K36me2 on heterochromatin was just published, in collaboration with labs of K. Yamagata, H. Kurumizaka, and H. Nishihara. Congratulations! https://t.co/fNItRDfwBA
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Work by Masaru Nakao, who is getting PhD, was just published. Mode of SUV420H2 heterochromatin localization through multiple HP1 binding motifs in the heterochromatic targeting module - Nakao - Genes to Cells - Wiley Online Library
onlinelibrary.wiley.com
SUV420H2 heterochromatic targeting module (HTM) contains three HP1 binding motifs and their cooperative binding to HP1 stabilizes, or locks, HP1 on heterochromatin. An HTM mutant that does not...
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A review with Hiroshi Ochiai and colleagues came out. Organization of transcription and 3D genome as revealed by live-cell i...
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Our #MidweekMovie shows actin dynamics in a #zebrafish embryo from Haruka Oda, @Cell_Tokyo_Tech, et al. They find that f-actin accumulates in the nucleus of early embryos & forms patches associating with condensing chromosomes. 📖@BiologyOpen: https://t.co/v42VvAClrZ
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Nuclear F-actin dynamics in the early embryo, in collaboration with Nadine Vastenhouw, Shige Kawashima, Motomu Kanai, and colleagues. Congratulations Haruka!
journals.biologists.com
Summary: Filamentous actin accumulates in the nucleus of zebrafish early embryos and forms patches associating with condensing chromosomes during prophase.
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Collaborative work led by Yoichi Shinkai revealed what happens to chromatin organization when mouse cells lack both H3K9 and H3K27 methylation marks. Congratulations Kei! https://t.co/IKyZy4cd7W
academic.oup.com
Abstract. Heterochromatin is a key architectural feature of eukaryotic chromosomes critical for cell type-specific gene expression and genome stability. In
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The formatted version of γ-H2AX dynamics paper by Fern (Watanya) is now available. https://t.co/JYSlO288dI
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Ph.D. work by Fern (Watanya) is now published. Congrats! Watanya Trakarnphornsombat, Hiroshi Kimura; Live-Cell Tracking of γ-H2AX Kinetics Reveals the Distinct Modes of ATM and DNA-PK in Immediate Response to DNA Damage. J Cell Sci 2023; jcs.260698. doi:
journals.biologists.com
Summary: Live-cell imaging reveals that DNA-dependent protein kinase, but not ATM, plays a primary role in the phosphorylation of histone H2AX during the immediate early response to DNA damages.
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STREAMING-tag paper (with RNA polymerase II Ser5ph-specific mintbody) came out. Congratulations Hiroaki, Hiroshi O, and all collaborators! https://t.co/sYGw1dJQeE
nature.com
Nature Communications - Using the newly developed STREAMING-tag system, the authors find that clusters of RNA polymerase II and BRD4 are formed specifically in the transcriptionally active state...
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Work by Misako Tanaka, a visiting Ph.D. candidate from Tokyo Medical and Dental University, was published. Congratulations! The role of H3K9me3 in oral squamous cell carcinoma
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Satoshi Uchino's paper was selected for one of the Year in Cell Biology 2022 articles. Congratulations!
Satoshi Uchino et al. develop a new probe for phosphorylated #RNA polymerase II which enables visualization of the sites of #transcription in living cells. https://t.co/zxZiTSlOTP From the Year in Cell Biology 2022: https://t.co/6cR9fhjdBX
#CellBio2022
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Congratulations Nadine, Ksenia, and colleagues!
Our story about the spark of life now in published form https://t.co/l0k0eNcE89, so it's time for a shout-out to @currentbiology, @AnneKnowlton1, and our anonymous reviewers for the efficient, pleasant, and constructive review process. Thank you!
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Work by Haruka Oda on nuclear filamentous actin in zebrafish early embryos, in collaboration with groups of Nadine Vastenhouw (Lausanne) and Shigehiro Kawashima and Motomu Kanai (Tokyo). https://t.co/85Nr3U1LOB
biorxiv.org
In the cytoplasm, filamentous actin (F-actin) plays a critical role in cell regulation, including cell migration, stress fiber formation, and cytokinesis. Recent studies have shown that actin...
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Work of a Ph.D. student, Fern (Watanya Trakarnphornsombat). She monitored γ-H2AX accumulation at DNA damage sites in living cells and found different regulations by ATM and DNA-PK.
biorxiv.org
DNA double-strand break (DSB) is a serious form of DNA damage that can cause genetic mutation. On the induction of DSBs, histone H2AX becomes phosphorylated by kinases, including ataxia telangiecta...
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In-person EMBO Laboratory Leadership Course (12/3; Tokyo) and International Symposium for Female Researchers in Chromatin Symposium (12/5; online).
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Congratulations Yohei, Takeshi, and colleagues!
Excited to share that our latest paper is finally out in @JCellBiol. Much data has been added since the bioRxiv version released in January.
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