Cardiac Trials
@CardiacTrials
Followers
14K
Following
8K
Media
1K
Statuses
2K
Simplified landmark cardiology trials app 📱 by Justin Sharim MD. Mission: to spread evidence-based medicine worldwide 🌎
Joined March 2022
This, friends, is why we do clinical trials 📚
0
5
19
Imagine if everything in life was as good as gold. It’s easy to invest in, could help grow your wealth, and protect it too. A timeless asset that stands strong when others may not.
92
183
3K
Abstinence from coffee intake in afib? Patients with afib have historically been advised to avoid coffee by some. This trial found abstinence to INCREASE afib burden—a practice changing trial altering our approach and underscoring the importance of RCTs. DECAF Trial, JAMA 2025 ♥️
0
10
16
PCSK9i without prior MI or stroke? PCSK9 inhibitors confer strong LDLc ⬇️ w/ outcomes in ODYSSEY (2015) and FOURIER (2017). This trial showed outcomes in patients absent prior vascular event, expanding the role of PCSK9i to the realm of prevention. VESALIUS-CV Trial, NEJM 2025 ♥️
0
1
4
Why don’t we routinely use antiarrhythmics to suppress PVCs after myocardial infarction? Why are class 1C antiarrhythmics contraindicated in those with coronary artery disease or structural heart disease? Both answers stem from this historic trial. CAST I Trial, NEJM 1991 ♥️
Seems like a good night to remind everyone that before 1991, nearly every cardiologist thought it was good to suppress PVCs after MI
0
1
15
A Floriday is what happens when “Why not?” meets “Why wait?”
3
1
40
Low dose dopamine to improve renal function in acute decompensated heart failure? Because clinical trials are equally important in showing us what does NOT work. ROSE Trial, JAMA 2013 ♥️
0
2
18
Treating hypertriglyceridemia with fibrates to lower cardiovascular risk? Because negative clinical trials are equally important, showing us what does NOT work. Use evidence to treat patients — not lab values. PROMINENT Trial, NEJM 2022 ♥️
2
31
75
The results of this trial were corroborated by the LEADER Trial, published in the same year
0
1
5
Bring the LTX-2 API into real production pipelines, powering 4K, 50fps, synchronized-audio video generation
3
7
170
Lowering CV risk in diabetes with GLP1 agonism? This large trial showed both improved outcomes — which in combo with LEADER Trial (published in the same year) ultimately rendered GLP1 agonism as diabetes first line Rx in the 2023 ESC guidelines. SUSTAIN-6 Trial, NEJM 2016 ♥️
1
1
8
Why do we give statins to patients with coronary artery disease? Where does this data originate? This landmark historic trial — dubbed the king 👑 of statin trials — was the first to definitively show the profound life-prolonging effects of statins. 4S Trial, Lancet 1994 ♥️
1
8
53
A resurgence of cardiac glycosides for heart failure? Once widely used, cardiac glycosides have fallen to the wayside in deference to quad therapy mortality benefit. This landmark study showed combined benefit with digitoxin, revisiting this arena. DIGIT-HF Trial, NEJM 2025 ♥️
0
3
31
Espero nunca ter FA, porque nunca vou abrir mão de tomar café 👍🏾
Abstinence from coffee intake in afib? Patients with afib have historically been advised to avoid coffee by some. This trial found abstinence to INCREASE afib burden—a practice changing trial altering our approach and underscoring the importance of RCTs. DECAF Trial, JAMA 2025 ♥️
1
2
4
DAPT following ACS revascularized by CABG? The landmark CURE trial rendered DAPT as ACS standard of care in 2001. Recent trials challenge this dogma: this trial showed DAPT to hold no benefit over aspirin monotx, and (unsurprisingly) lead to ⬆️ bleeding. TACSI Trial, NEJM 2025 ♥️
0
5
36
Kizma and The Last Werewolf is a tale of a giant 7-foot werewolf in Texas. Deputy Sheriff Kizma and Emmitt Hercules hunt him and go on a terrifying adventure that takes them all the way to Mexico. The end has a twist that is certain to surprise you.
0
16
143
Abstinence from coffee intake in afib? Patients with afib have historically been advised to avoid coffee by some. This trial found abstinence to INCREASE afib burden—a practice changing trial altering our approach and underscoring the importance of RCTs. DECAF Trial, JAMA 2025 ♥️
0
10
16
Ablation vs drug therapy for rhythm control in atrial fibrillation? This trial showed ablation to be superior to drug therapy (class I and III drugs such as flecainide and amiodarone) in keeping afib at bay. EARLY-AF Trial, NEJM 2021 ♥️
1
10
51
Check out all pulmonary hypertension trials included in the Cardiac Trials app 📱 https://t.co/FCFC5feTsE
0
5
12
Addressing the underlying cause of pulmonary arterial hypertension? Unlike traditional therapies like PDE5 inhibitors which simply vasodilate, sotatercept remodels the pulmonary vascular bed itself👇— now with demonstrable mortality benefit. STELLAR Trial, NEJM 2023 ♥️
1
19
63
Lowest price for USA-made 100% organic cotton shorts @ATGUSAMade I hope these inspire someone out there to build closer to home, wherever that is.
21
71
692
Mastering ECG Clues into Cardiomyopathies ♥️ 📚 The ECG remains an indispensable asset in our toolbox 📖 https://t.co/ZgyLHxlkkG
0
45
153
Initial management of pulmonary arterial hypertension? This trial showed us that combination therapy with an endothelin antagonist and a nitric oxide potentiatior was superior to either alone. A trial that has shifted our approach to PAH patients. AMBITION Trial, NEJM 2015 ♥️
1
11
44