This allows our scientists to study rare cellular events and dynamic organelle behavior in real time, in both healthy and perturbed states, without disrupting cell function. (4/4) #AgingScience

Captured using the Snouty light-sheet microscope developed at Calico, the GIF illustrates how the system enables long-term, high-speed imaging in 3D with minimal phototoxicity. (3/4)

Tell us what you think.

Shown here are U2OS osteosarcoma cells (a kind of bone cancer) progressing through mitosis over 18 hours. Mitochondria are labeled with a green fluorescent tag. The panels on the top and the right show the cells viewed from the sides. (2/4)

Tracking how cells organize their internal structures over time is critical to understanding the biology of aging and disease. (1/4)

Anurag Sethi, Principal Data Scientist, studies large human cohorts to better understand aging. He turns complex data into insights that inform our research and drug discovery programs. Anurag shares what makes his work rewarding. https://t.co/Xp8BZNDZrh #AgingScience

We’re excited to announce FDA Orphan Drug Designation for ABBV-CLS-628, an investigational therapy to treat ADPKD, the most common inherited kidney disease. Last month, it received Fast Track Designation and is now in a Phase 2 clinical trial. https://t.co/0Jay4rJoXL

We’re looking forward to ASN #KidneyWk 2025. Stop by booth 1142 to learn about our PAPP-A development program and ABBV-CLS-628, an investigational therapy for the treatment of Autosomal Dominant Polycystic Kidney Disease, which was recently granted FDA Fast Track Designation.

Most days, we collaborate. On Halloween, we get a little competitive. Thanks to all who joined us for this year’s Calico-Ween celebration, and congrats to this year’s costume contest winners! #LifeatCalico

This system helps scientists investigate how molecular signals and environmental factors influence vessel formation. It’s helping our researchers uncover the signals that support healthy vessel growth, and what might go wrong as we age or in disease. (4/4)

The green highlights human blood vessel cells as they form branching structures. The blue shows cell nuclei and the scaffold that guides cell growth and organization. (3/4)

Using a 3D microfluidic platform, also called an “organ-on-a-chip,” our scientists created a model that mimics how blood vessels grow in the human body, showing angiogenesis in action. (2/4)

The formation of new blood vessels — known as angiogenesis — is a fundamental biological process that plays an important role in health and disease. (1/4)

@Oliver__Hahn Oliver and paper co-author @Claire_Gizowski shared more details about their new research with @Alzforum :

At the Interventions in Aging Conference, PI @Oliver__Hahn shared research on how the brain’s environment drives microglia (brain’s immune cells) to age at different rates. The results help explain regional hotspots of brain aging & provide new insights into neuroinflammation.

We are pleased to welcome Philip R. Kym, Ph.D., as our new Head of Drug Discovery. Most recently serving as AbbVie’s VP of Global Medicinal Chemistry, Dr. Kym is an accomplished scientific leader with nearly 30 yrs. of biopharma experience. Read more: https://t.co/KTAUEPj4Iz

Automation Engineer Andrea Larsen designs methods that accelerate our research and help scientists answer experimental questions more efficiently. We asked Andrea what she finds most fulfilling about her work. Explore Life at Calico: https://t.co/Xp8BZNDZrh #AgingScience

We’re pleased to announce FDA Fast Track Designation for ABBV-CLS-628, an investigational therapy developed in collaboration with AbbVie for Autosomal Dominant Polycystic Kidney Disease (ADPKD). ABBV-CLS-628 is now in a Phase 2 clinical trial. Read more: https://t.co/c8JB1HyvsQ

Ten years ago, we partnered with @broadinstitute to ask: could aging biology be understood well enough to change the course of age-related disease? Together, we’ve advanced new targets, tools & clinical programs. Read more here: https://t.co/hvoc7P1chj

It’s #PostdocAppreciationWeek. Meet Prashant Rao, a postdoc on our Protein Sciences team. He studies GPCRs — key proteins that help cells respond to signals and are central to drug discovery. We asked Prashant about his experience at Calico.

It’s #PostdocAppreciationWeek. Gill Fitz is a postdoc in the Gillich Lab, where she studies lung biology and the changes in tissue function that come with age. Listen as Gill reflects on her research and what excites her most about working at Calico.