Alzforum
@alzforum
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A news and information resource website helping scientists advance AD research since 1996. Alzforum doesn’t endorse any specific product or scientific approach.
Boston, MA
Joined August 2009
In people with AD, tau tangles found within the touch-sensing stations of the spinal cord might explain loss of tactile sensitivity. @2024_HUST
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Scientists identified 49 proteins genetically linked to cerebral small vessel disease. This common co-pathology with #alzheimersdisease contributes to risk for ARIA. @wustl @UTokyo_News
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ACFMarketWrap. Wall Street stumbled into December. The S&P 500 -0.37%, $IXIC -0.49%, and $DJI -0.51% as caution resurfaced after a choppy November. Traders braced for a heavy data week, including the delayed September PCE, all ahead of next week’s pivotal FOMC decision. Tech led
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New research identifies inflammatory, C5aR1-positive microglia as potential drivers of the swelling that follows traumatic brain injury.
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A new method for detecting genetic variants that disrupt RNA splicing has revealed the function of an Alzheimer’s risk allele: It drops exon 7 from the MS4A3 gene. @PennMedicine
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In microglia, blocking formation of cholesteryl esters boosts release of sTREM2, which drives Aβ uptake. #alzheimersdisease @MassGeneralNews
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Does the Alzheimer’s risk gene INPP5D make lysosomes leaky? In iPSC-microglia, lowering its expression may cause the cells to spill their proteases into the cytosol and spark inflammatory signaling.
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Study shines light on the “dark genome” of Alzheimer’s. Long-read sequencing uncovered retrotransposon activity near risk genes and methylation shifts in repetitive DNA, revealing new genetic instability in AD. @BrownUniversity
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A modeling study finds that once aggregation of α-synuclein or tau overwhelms cellular removal machinery, runaway aggregation ensues. @Cambridge_Uni @SceinceStowers
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Neuroprotective microglia express immunomodulatory T-cell receptors and restrain inflammatory responses from other microglia. #alzheimersdisease @RockefellerUniv @IcahnMountSinai
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Glia team up in #Alzheimersdisease: astrocyte reactivity rises with amyloid and tau, though only when riled-up microglia are in the mix. @mcgillu @ufrgsnoticias
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In the wake of DNA repair, “chromatin fatigue” can hamper gene expression. Does this contribute to cellular aging? @uni_copenhagen
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Cerebral small vessel disease and #alzheimersdisease have little in common at the genetic level, even though they frequently occur together. @imperialcollege
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In mice, the hypertension hormone angiotensin II greatly affected the brain within days. It revved up neuronal activity and damaged myelin. #alzheimersdisease @WeillCornell
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Seventy-five hundred steps per day may delay the cognitive and functional decline of Alzheimer’s disease. Why? Because the exercise slowed accumulation of neurofibrillary tangles. @MassGeneralNews
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🎥 Enlivex Therapeutics $ENLV: CEO Interview Highlights Breakthrough Osteoarthritis Data In a recent interview, CEO Oren Hershkovitz shared compelling Phase I/II results from Allocetra™ in age-related osteoarthritis. With a $7B+ global osteoarthritis market, no FDA-approved
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A PSEN1 variant in a father and son with early-onset Alzheimer’s abolishes γ-secretase activity. What explains their dementia? @VIBLifeSciences
https://t.co/Ny2K43mpbP
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New biomarker for CAA? CRIP1, a vascular protein, tracks with CAA severity, shows up in CSF, and may seed amyloid aggregation. A genetic variant also decreases a person’s risk for #alzheimersdisease. @EmoryMedicine
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