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Treatment monitoring: CTCs can be used to monitor treatment response and disease progression

Clinical significance:. Prognosis: The presence and number of CTCs can be prognostic in various cancers, including breast, prostate, colorectal, and lung cancers239.

Detection methods: Various techniques are used to detect CTCs, including immunoaffinity-based methods, size-based isolation, and advanced imaging technologies49

Rarity: CTCs are extremely rare, typically found in frequencies of 1-10 CTCs per mL of whole blood in patients with metastatic disease1

Definition: CTCs are cancer cells originating from primary tumors that have shed into the blood or lymphatic circulation13 Metastasis: CTCs are considered precursors to metastasis, as they can potentially seed new tumors in distant organs15

Circulating tumor cells (CTCs) are cancer cells that have detached from a primary tumor and entered the bloodstream or lymphatic system. They play a crucial role in the process of cancer metastasis. Here are some key points about CTCs in cancer: