Brownfield Lab
@BrownfieldLab
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Fans of the lung and the processes that construct and repair them.
Mayo Clinic - PCCM,BMB, & BMEP
Joined August 2022
š«š©āš¬Hot off the (pre)press! Alveolar cells flirt with fate ātil C/EBPĪ± lays down the law. A pulse of Dlk1 suppresses Notch to split AT1/AT2 pathsālike molecular speed dating. Injury? CHOP crashes the party. https://t.co/goXnRJJZie
@MayoClinic @HarvardEnvHlth
biorxiv.org
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My group and I were thrilled to receive our second Notice of Award of an R01 we submitted to Dev2. We thank the study section members,@nih_nhlbi, @HarvardEnvHlth, and @MayoPCCM. We are escatic to pursue the molecular determinants of fate plasticity in the lung!
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My group and I were thrilled to receive our first Notice of Award of an R01 we submitted to LIRR. We thank the study section members, @nih_nhlbi , @HarvardEnvHlth , and @MayoPCCM . We are stoked to pursue the biophysical underpinnings of stem cells in the lung!
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Glad to share our new paper in cell reports. Niche-mediated repair of airways is directed in an occupant-dependent manner: Cell Reports
cell.com
Lyu etĀ al. show that complete activation of the peribronchial niche involves removal of an inhibitory Shh signal and initiation of an activating Wnt7b signal after airway injury. Communication...
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Thanks for bringing attention to our work!
Read Dr. Brownfield's et al work on alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling. The work by Drs. Brownfield and Krasnow's team will help develop cell-based therapeutics to treat lung disease. @NatureComms
https://t.co/EGuBNvvDjR
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Oh dear. I am finding new problems in a @CurrentBiology paper by the current Stanford University president, while working at Genentech (but not the corresponding author). https://t.co/fLpmRIRcPC
https://t.co/5B3sREXwda
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.@MayoClinic is one of the first to offer a #RegenMed Ph.D. track to train scientists and physicians to deliver health care of the future. https://t.co/uKbAyhzERP
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.@MayoClinc #RegenMed is training the regenerative scientists of the future to advance an emerging field focused on rebuilding and restoring health. https://t.co/kzkv0zK6Bk
newsnetwork.mayoclinic.org
Experts predict that regenerative medicine will transform clinical practice. A conservative estimate is that 20% of future medical and surgical solutions will involve regenerative solutions. Regene...
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We published @NatureComms! It started @StanfordBiochem, completed @HarvardEnvHlth, and accepted now @MayoPCCM @Mayocliniclabs @MayoRegMed. Thanks @nih_nhlbi @ACSCAN! Next we translate our findings to improve regenerative medicine for the lung! #MayoREGS
https://t.co/wv6OHwX1b4
nature.com
Nature Communications - Here the authors show that FGF signaling initiates alveolus development in mouse lung by inducing AT2 fate and a secondary signal for AT1 fate, and continuously maintains...
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