Ultimately, with the range of Nras mutations, mutational burden, and neoantigen expression across these cell lines, this series establishes a new and robust resource for testing targeted and immune-based therapies for NRAS-mutant melanoma in an immune-competent model.

Moreover, this approach permitted the in vivo elimination of melanocytes which acquire strong, immune-stimulating neoantigens that could hinder cell line implantation.

Derivation of these cell lines from melanomas that developed in UV-irradiated mice ensured a mutational spectrum and mutational burden analogous to human disease.

I am thrilled to announce the publication of our series of NRAS-mutant melanoma cell lines syngeneic to the C57BL/6 mouse model! Awesome collaborative work with @ChristinBurd, @DaelinJensen, and @KYTsaiLab.

RT @OdedRechavi: When you need to enter the lab but don't have your ID badge

RT @ChristinBurd: Phaedra Ghazi presents new data suggesting that combination ULK and KRAS inhibition may improve therapeutic responses in….

RT @Dr_Mmadili: Having interesting and fun conversations with fellow post docs at the Huntsman Alliance for Postdocs lunch @NeliMUlrich @ns….

RT @JExpMed: .@mark_silvis, @DilruSilva, @conankinsey, @MaxTheSFCat et al. @huntsmancancer show that inhibition of CDK4/6 and lysosome func….

RT @ChristinBurd: Congrats to Brandon Murphy, @DaelinJensen & collaborators from @KYTsaiLab on this study characterizing a new set of NRAS….

RT @NatureComms: Study uses an allelic series of conditional mouse models to investigate the molecular mechanisms underlying the enrichment….

So excited that my primary graduate research project was finally published! Special thanks to @ChristinBurd for her support and guidance during my graduate tenure!.

Only a chosen few can relate to the satisfaction of getting a 0.999 R squared value on a standard curve for a BSA/Bradford assay.

A surreal feeling to finally see years worth of work culminate into such an exciting story. This couldn't have been possible without the help of all the co-authors and my PI @ChristinBurd

RT @ChristinBurd: Check out this magnum opus by graduate student @BMurphy1500! It's a lot to unpack, but I'll try to do it justice. 1/7.ht….

The two worst places to be left alone with your thoughts are in bed and in cell culture.

When experiments stop working it’s best to just open a whole new arm to your project so you don’t have to focus on those particular experiments for 2-3 months #gradstudentlife.

RT @NatureNews: Pulitzer prizewinner Cormac McCarthy shares his advice for pleasing readers, editors and yourself.

RT @ChristinBurd: Excited to announce that our newest work with collaborators @rosslevinemd @ShainLab and @bowman_rl is now available on Bi….