Arto Pulliainen
@ArtoPulliainen
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bacteriologist, protein chemist, founder and head of TCML (Turku Cellular Microbiology Laboratory), University of Turku, Finland.
University of Turku, Finland
Joined April 2015
Oct. 24th, TCML researcher Madhukar Vedantham defended his PhD thesis on mechanisms of intestinal inflammation - https://t.co/F16wFhbmkW Many thanks to TCML funders, collaborators and opponent Tuure Kinnunen from @UniEastFinland for such an inspiring discussion. @UniTurku
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TCML attends ETOX2025 close to Bilbao at Arantzazu, Basque Country, Spain - biannual global meeting venue of the experts of bacterial protein toxicology.
etox-meetings.org
European Workshop on Bacterial Protein Toxins (ETOX). June 27 - July 1, 2027. Groningen, The Netherlands
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Preprint out. Using a mouse model of Salmonella Typhimurium infection, also involving single cell RNA-Seq data analysis, we report new molecular insights on the regulation of gut inflammatory response. https://t.co/jFfansWOcV
biorxiv.org
Salmonella enterica subspecies enterica serovar Typhimurium ( S. Typhimurium) is an enteropathogen annually causing millions of acute infections ranging from gastroenteritis to life-threatening...
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The lab welcomes our new member, undergraduate researcher, biology student Amanda Barsk. She aims to understand what happens in bacterial infections when exotoxins recognize their host cell surface protein receptors, via characterization of the receptor protein interactomes.
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Paper out. We report characteristics of the fecal microbiota in common migratory birds and bats. The data implies that these vertebrates may contribute to the transmission of enteric bacterial pathogens across the European continent. @SuomenAkatemia
https://t.co/rDrJ0waVtR
journals.asm.org
The understanding of gut microbiota composition and dynamics in wild vertebrate populations, especially in highly mobile vertebrates, birds and bats, remains limited. Our study sheds light on the...
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paper out on new research tools @jbiolchem We describe an ADP-ribosyltransferase-based biocatalytic process to produce new kinds of non-hydrolyzable NAD+ analogs. https://t.co/jUsjGr7m8D
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Paper out @jbiolchem of a novel pertussis toxin neutralizing function for the human acute phase protein alpha1-antitrypsin with our colleagues from @uni_ulm and elsewhere in Germany and USA. https://t.co/LB6X5aG73M
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The lab welcomes our new member, Ilona Nieminen (BSc). She optimizes our new yet-to-be-published drug screening assay, in collab. with Kari Kopra (University of Turku, Dept. of Chemistry) and aims to identify new bacterial exotoxin-neutralizing compounds. #AMR
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Paper out @FASEBorg
https://t.co/FP4AoZfJif We report new molecular insights on the regulation of gut inflammatory response by using mouse models of #Salmonella infection and inflammatory bowel disease (IBD), and samples of an #IBD patient cohort. #ADPribosylation #PARP14
faseb.onlinelibrary.wiley.com
Parp14 has a role in the maintenance of colon epithelial barrier integrity in a mouse model of inflammatory bowel disease. Parp14-deficient mice displayed increased rectal bleeding as well as...
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The lab welcomes our new member, undergraduate researcher Ellen Skrabb (BSc) from @AboAkademi. She works on functional characterization of new bacterial #exotoxin variants identified with our #bioinformatics tool on environmental shotgun #metagenome data. @UniTurku
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🌍🐧🦇🤗 Our new paper @OneEarth_CP: Slow-lived birds and bats carry higher pathogen loads https://t.co/3eXoDKnYkO…
@luomus @HiLIFE_helsinki @SuomenAkatemia @_EBCC
@AksuLehikoinen @thomaslilley77 @ArtoPulliainen
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May 24th, our Moona Sakari defended her PhD thesis on bacterial exotoxins - https://t.co/OSIwmhJi63 Many thanks to our funders, collaborators in Finland and abroad and to opponent Christian Hedberg from @umeauniversity for such an inspiring discussion. @UniTurku
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Uusi syvällisempi tieto bakteerien taudinaiheuttamistekijöistä tehostaa rokote- ja lääkekehitystyötä. Tutkimustuloksemme parantavat myös kliinisen diagnostiikan tehokkuutta infektiotaudin aiheuttajan ja sen alkuperän määrittämisessä.
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Kuinka yleisiä ihmiselle ja eläimille vaaralliset bakteerit ovat muuttavissa linnuissa ja lepakoissa? Ovatko nämä bakteerit vastustuskykyisiä antibiooteille? Millaisia taudinaiheuttamistekijöitä kuten esimerkiksi toksiineja nämä bakteerit tuottavat?
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Oma osuutemme Diseases-on-Wings hankkeessa kartoittaa muuttavien lintujen ja lepakoiden kantamia taudinaiheuttajabakteereita ja niiden ominaisuuksia.
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National news coverage for our work on bacterial pathogens. @yleuutiset kävi tutustumassa tutkimusryhmämme toimintaan @UniTurku osana #CLIHE @SuomenAkatemia ohjelmahanketta Diseases-on-Wings jossa mukana @luomus tutkimusryhmän johtajat @thomaslilley77 ja @AksuLehikoinen.
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Paper out @Toxins_MDPI . Host cell chaperons fold and activate bacterial toxins. Glad to contribute to this study led by Katharina Ernst @uni_ulm identifying TRiC/CCT chaperon inhibitor neutralizing pertussis toxin. https://t.co/wrDzM2PwgI
mdpi.com
Pertussis toxin (PT) is a bacterial AB5-toxin produced by Bordetella pertussis and a major molecular determinant of pertussis, also known as whooping cough, a highly contagious respiratory disease....
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Paper out @theAGA_org. This was a laborious task to isolate and immortalize cells from the northern bat for our bacterial evolution projects. Here, the cells were used by @thomaslilley77 @BatLabFinland to determine the northern bat reference genome.
academic.oup.com
Abstract. The northern bat (Eptesicus nilssonii) is the most northern bat species in the world. Its distribution covers whole Eurasia, and the species is t
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Closing seminar of #CLIHE Climate Change and Health Academy Programme 2020-2023 @SuomenAkatemia. Here, I summarize our Europe-wide data with @luomus PIs @thomaslilley77 @AksuLehikoinen on what bacterial #pathogens with what #virulence and #AMR factors are found in wild-life.
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Paper out on the development of DNA nanoflower-based #nanoparticle to treat #MRSA #biofilm #keratitis. Glad to be involved in this study led by Hongbo Zhang and colleagues at @AboAkademi and abroad in China. @UniTurku
https://t.co/HtumiNPmVs
onlinelibrary.wiley.com
Development of an eye-drop system for chemo-gene therapy targeting methicillin-resistant Staphylococcus aureus (MRSA) biofilm-associated bacterial keratitis. DNA nanoflowers (DNFs) loaded with...
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