A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells

RT @VFCracan: Pre-print is here:

Our story is finally out in PlosGenetics.We identified novel RB1-specific synthetic lethal interactions that are conservative between flies and humans. We also created a novel Drosophila cancer model. I would like to thank everyone for their help!.

The tyrosine degradation pathway can be targeted with an FDA-approved drug, Nitisinone/Orfadin/NTBC that could be interesting to test in mammals. I would like to thank everyone for their help and support!.

Our story is finally out in eLife. We demonstrate the connection between aging, mitochondria dysfunction, and tyrosine-derived neurotransmitter production. Suppression of tyrosine degradation extends lifespan and promotes production of neurotransmitters.

Pre-proof version of our review:. Targeting metabolic pathways for extension of lifespan and healthspan .

RT @PerrimonLab: 'First in Fly' by Dr. Stephanie Mohr named one of the ten best science books of 2018 by Smithsonian magazine! Congratulati….