@AliDGuler @uvabio @UVA Come and join us:

At UVA, you’ll be part of a vibrant, collaborative neuroscience community spanning Biology, Medicine, Engineering, Data Science & more… in beautiful Charlottesville, VA. Apply today & help shape the future of neuroscience: https://t.co/nbM1bnBsJi #Biology #UVA

We welcome applicants working on: • Neural circuits & plasticity • Glia & brain interactions • Behavioral genetics & genomics …and more! Join a highly interdisciplinary dept with access to state-of-the-art imaging, genomics, metabolomics, and computing resources. #NeuroJobs

We’re hiring! @uvabio @UVA_PFN @UVA UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. Apply by Oct 15, 2025. Start Aug 2026. https://t.co/NnB4ZP1zcx #Neuroscience #FacultyJobs

At UVA, you’ll be part of a vibrant, collaborative neuroscience community spanning Biology, Medicine, Engineering, Data Science & more… in beautiful Charlottesville, VA. Apply today & help shape the future of neuroscience: https://t.co/nbM1bnBsJi #Biology #UVA

We welcome applicants working on: • Neural circuits & plasticity • Glia & brain interactions • Behavioral genetics & genomics …and more! Join a highly interdisciplinary dept with access to state-of-the-art imaging, genomics, metabolomics, and computing resources. #NeuroJobs

We’re hiring! @uvabio @UVA_PFN @UVA UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. Apply by Oct 15, 2025. Start Aug 2026. https://t.co/NnB4ZP1zcx #Neuroscience #FacultyJobs

LUKE KORNET TONIGHT — 10 POINTS 9 REBOUNDS 7 BLOCKS 100% FG GAME OF HIS LIFE. 🔥🔥🔥🔥

Take the leap, it's easy

A dedicated neural circuit through which small molecule GLP1RAs modulate reward processing, suggesting broad therapeutic potential in conditions of dysregulated dopamine signaling including substance use disorder and binge eating https://t.co/SQJNvrJNmp

It turns out today is the humanized "Glp1rS33W" rodent model day. Here is another one published today by Eli Lilly and Company @EliLillyandCo https://t.co/AseZT1OX0q Didn't know... we could have had a party 😉🥳🎉

Our collaborative team at UVA Biology Department @uvabio including the labs of Chris Deppmann @deppmann and John Campbell @AUGCsoup are awesome. They all made it fun!

You can read more about it here: https://t.co/QZXP0fABjO Send us feedback on how we can improve our manuscript. All this work was led by three very talented graduate students: Lizzie Godschall @LizzieGodschall, Buğra Güngül @bugragungul and Isabelle Sajonia @isabellesajonia. 15/

Finally, we found that, through their projection targets, CeA-Glp1R neuron activation by these GLP-1RAs inhibits dopamine release in response to rewarding food. This highlights a mechanism for reducing reward-driven eating and suggests potential for addiction treatment. 14/

Remarkably, we observed increased calcium transients in these cells after injecting small-molecule GLP-1RAs. This response, expected from Gs-coupled receptors, confirms that small-molecule GLP-1RAs can directly access the brain when delivered peripherally. 13/

This finding raised a new question: Do small-molecule GLP-1RAs reach deep into the brain to activate these neurons? To explore this, we co-expressed a genetically encoded calcium indicator and the humanized receptor in CeA-Glp1R neurons. 12/

Activation of CeA-Glp1R neurons by a small molecule GLP-1RA inhibited reward-driven food intake without affecting homeostatic feeding—remember, only neurons expressing the humanized receptor via viral vectors are sensitive to small-molecule GLP-1RAs in these assays. 11/

We used conditional viral vectors to express humanized receptor in cells naturally expressing mGlp1r in specific brain areas. This chemogenetic approach allowed selective activation by small-molecule GLP-1RAs, allowing precise dissection of brain region-specific mechanisms. 10/

Using c-Fos, we observed that brain areas activated by peptide-based GLP-1RAs were also activated by small-molecule GLP-1RAs. We found a particularly intriguing response in the central amygdala (CeA). 9/

Using this humanized mouse model, we confirmed that oral and peptide-based GLP-1RAs similarly suppress appetite. These drugs matched liraglutide in reducing both homeostatic and reward-driven (hedonic) food consumption. 8/