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Adrien Leger Profile
Adrien Leger

@AdrienLeger2

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Director of Modified Bases Research at @nanopore. Moving slowly to where the sky is less depressing. https://t.co/U30YEgDbsO

Oxford, England
Joined September 2014
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@AdrienLeger2
Adrien Leger
2 months
🚨 We’re hiring ! 🚨.Join our cutting-edge research team as a molecular biologist at @nanopore HQ in Oxford. Perfect for a fresh PhD or MSc with a couple of years’ experience. Work at the interface of chemistry, molecular/synthetic biology and AI. šŸ‘‰
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@AdrienLeger2
Adrien Leger
2 months
RT @Stoibs11: More details on new RNA modified bases detectable with @nanopore sequencing. #NanoporeConf
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@AdrienLeger2
Adrien Leger
2 months
RT @Stoibs11: Dorado 1.0 šŸš€release with new RNA modified base models for 2’Ome as well as improvement of all DNA and RNA modified base model….
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@AdrienLeger2
Adrien Leger
2 months
RT @Daniela_Bezdan: Tweet 1/2.WOW—2’O-methylation detection in direct RNA-seq is here! A breakthrough for RNA therapeutics, viral evasion,….
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@AdrienLeger2
Adrien Leger
2 months
RT @RAKemal: ONT @nanopore is the only sequencing tech capable of direct RNA seq (without cDNA conversion step). Not only that, ONT can det….
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@AdrienLeger2
Adrien Leger
2 months
RT @bioinformer: Who has DNA methylation on ~5,000 microbes sequenced w/@nanopore? We do! . Who’s working hard on getting this data out bef….
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@AdrienLeger2
Adrien Leger
2 months
RT @Stoibs11: The future of @nanopore sequencing is here now! #NanoporeConf #Proteomics
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@AdrienLeger2
Adrien Leger
2 months
RT @iiSeymour: Dorado is 1.0! šŸŽ‰. This London Calling release updates our DNA and RNA models to v5.2 with a new suite of mod models that are….
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@AdrienLeger2
Adrien Leger
8 months
RT @nathanbaggers: Excited about @nanopore's collaboration with @uk_biobank to create the first comprehensive epigenetic map of the human g….
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@AdrienLeger2
Adrien Leger
8 months
RT @lh3lh3: The latest hifiasm can directly assemble standard @nanopore simplex R10 reads, without HERRO correction or other preprocessing,….
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@AdrienLeger2
Adrien Leger
8 months
We have been busing working on research models to detect all 2'Ome-RNA modified nucleotides on top of PseudoU, m6A, m5C and Inosine using @nanopore dRNA seq. Preliminary results on Human #rRNA are very exciting. SeešŸ¦‹for more details
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@AdrienLeger2
Adrien Leger
8 months
RT @Libby_Snell_: I am absolutely thrilled to be back in Kanazawa, Japan (a fave!), for the #tRNA2024 conference! It was my pleasure to pre….
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@AdrienLeger2
Adrien Leger
8 months
šŸ’™ .
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@AdrienLeger2
Adrien Leger
8 months
It's Christmas in advance with a very special @nanopore #opendata release ! šŸŽ….Today we are releasing our 5mC 5hmC and 6mA DNA mod synthetic control datasets with each mods in all possible 5 mers contexts. All nicely wrapped in a comprehensive validation blog post.šŸŽ.
@Stoibs11
Marcus Stoiber
8 months
New blog: Modified Base Best Practices & Benchmarking for @nanopore 🧬 sequencing Includes:. * Raw POD5 files for synthetic ground truth strands.* Modified base calling best practices.* Modkit recommendations. Check it out: #methylation #bioinformatics.
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@AdrienLeger2
Adrien Leger
8 months
RT @Stoibs11: New blog: Modified Base Best Practices & Benchmarking for @nanopore 🧬 sequencing Includes:. * Raw POD5 files for synthetic gr….
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epi2me.nanoporetech.com
Modified bases, including methylation, regulate many biological processes - from eukaryotic gene…
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@AdrienLeger2
Adrien Leger
8 months
RT @slavov_n: The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.
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@AdrienLeger2
Adrien Leger
9 months
RT @RosemaryDokos: Low coverage (5x) @nanopore data vs methylation arrays delivers far more data. Great talk by the wasatch team at #ashg20….
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@AdrienLeger2
Adrien Leger
9 months
RT @nanopore: Methylation calling made easy—just #SwitchON. Direct nanopore sequencing captures methylation and characterises genetic varia….
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@AdrienLeger2
Adrien Leger
9 months
RT @ewanbirney: Some perspective here - like protein modification - phosphorylation, acteylationn etc - and DNA modification - 5mC, 5hmC an….
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@AdrienLeger2
Adrien Leger
9 months
RT @ewanbirney: When we look at the kmers around the sites, we see enrichment in the DRACH motif and the known m5C motifs, along with novel….
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