4R-RTG
@4r_rtg
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Joined August 2023
4R RTG has 11 exciting PhD positions in the field of R-loop biology! We are looking for curious minds who are passionate about molecular biology! #RNAbiology, #Rloop.Check the projects here: Apply via @IPPMainz by 24 October.
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Genome-wide mapping of protein-RNA interactions with iCLIP. Register until 4th December for the #EMBOiclip2 practical course in Genoa. Organized by @koenig_lab @TheSibleyLab @tartaglialab @mixmue and Kathi Zarnack. Funded by @EMBOcourse, @ItsRMaP1
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RNase H2 degrades toxic RNA:DNA hybrids behind stalled forks to promote replication restart | The EMBO Journal
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RT @R_loop_papers: Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops
pubmed.ncbi.nlm.nih.gov
Hypoxia is a common feature of solid tumors and is associated with poor patient prognosis, therapy resistance and metastasis. Radiobiological hypoxia (<0.1% O2) is one of the few physiologically...
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Break-induced RNA-DNA hybrids (BIRDHs) in homologous recombination: friend or foe?
pubmed.ncbi.nlm.nih.gov
Double-strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell proliferation and genome integrity. Depending on cell cycle stage, DSBs are preferentially repaired by...
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Live-cell imaging unveils distinct R-loop populations with heterogeneous dynamics
pubmed.ncbi.nlm.nih.gov
We have developed RHINO, a genetically encoded sensor that selectively binds RNA:DNA hybrids enabling live-cell imaging of cellular R-loops. RHINO comprises a tandem array of three copies of the...
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We are excited to announce that our first cohort of 4R PhD students start their PhD today!.
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