RT @KECKSchool_USC: A connection between Alzheimer’s and cholesterol? 🧪. Researcher Hussein Yassine, MD, @usccpbh, discovered a link betwee….

5/5: Accumulation of oxidized cholesterol in lysosomes in APOE4 AD is an important mechanism for lower endolysosomal recycling and cellular senescence. Drugs targeting lysosomal lipids are promising strategies in AD.

4/5 When we lowered oxysterols using cyclodextrin in vivo, ABCA1 recycled to the plasma membrane, and neuroinflammation was reduced.

3/5: Proteomic discovery experiments identified the cholesterol sensor, Caveolin-1 as the mechanism for ABCA1 sequestration into lysosomes. The accumulation of oxysterol species in APOE4 induced ABCA1 and trapped it in lysosomes.

2/5: We previously identified that APOE4 traps ABCA1 in lysosomes of cell and animal models. Here, we found more ABCA1 in lysosomal fractions isolated from post-mortem brain tissue samples, indicating that more ABCA1 is sequestered into lysosomes with APOE4 AD.

1/5: We observed a paradoxical increase in ABCA1 expression in APOE4 brain tissues with AD compared to controls. Increased ABCA1 expression was associated with cellular senescence. This led us to question whether increased ABCA1 expression translated into better chol efflux.

Is making brain HDL by inducing ABCA1 a viable strategy for APOE4 Alzheimer's? Our talented researcher Dr. Shaowei Wang has looked deeply into this question over the past 6 years, and the work has finally been published 5/5:.

In a systematic review, we find little evidence for omega-3 polyunsaturated fatty acids (n-3 PUFA) supplementation on cognition in a general population:

How do brain lipids influence the development of cellular senescence in the brain? We propose the over-activation of cPLA2 as a key driver of oxidized lipids and senescence and introduce the application of V-SYNTHES to develop potent cPLA2 inhibitors:

In this work, our talented PhD student Boyang Li analyzes complex data sets to identify signatures of cholesterol metabolism as key drivers of microglial cellular senescence in AD:

I pray for peace for all my friends and family in the Middle East. What keeps us together is far more than what drives us apart.

We are honored to have the new USC Center for Personalized Brain Health featured in Science.

How does the brain metabolism of the omega-3 DHA change across the lifespan in individuals carrying the APOE4 allele? Credit to the talented Brandon Ebright for leading this review. @KECKSchool_USC , #USCMann, #Alzheimers , #APOE4.

RT @ChrisSalazarPhD: It was an honor to co-chair the scientific session @alzassociation on Recruitment of Latino/a/e/x Participants to Rese….

How do vegetarians compensate for lower intake of DHA or EPA in their diets? @KermanBilal @wade_self and I hypothesize that clues to this question are in the gut microbiome. Excited to collaborate with the Alzheimer's Gut Microbiome Project #Alzheimers .

RT @MeredithBraskie: 📣🎉Congrats to PhD student, @KoralWheeler, who led our new review article in the Journal of Alzheimer's Disease:."Using….

RT @KermanBilal: Our last paper of 2023 (or first of 2024) is out! Together with @yassinelab1 and @wade_self we discussed #microbiome's eff….

Slavoj Žižek posits: "Why wish to be happy when you could be interesting?". May 2024 bring us interesting and curious discoveries!.

Happy Holidays! Fun to work with a great and diverse team.

I am proud of Marlon V. Duro and Juno Van Valkenburgh and thankful to @kaichen_USC for publishing the method for making 18-F DHA for the first time. This tool will ultimately help us study the effects of APOE4 on brain DHA metabolism in humans