Woodson Lab
@woodson_lab
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RNA detectives on a mission to catch RNA in the act of folding & uncover how proteins helped. Run by grads/postdocs. Sarah Woodson Lab @JohnsHopkins
Joined November 2019
This bunch of RNA lovers knows how to unwind! Enjoying A-U-tumn and apple picking 🍎🍏
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Congratulations to Elise White @elisew00 on winning a poster prize at the Regulating with RNA in Bacteria and Archaea meeting in Strasbourg! 🎉🎉
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Our new paper is out in PNAS! We show that competition for binding to the Hfq matchmaker disfavors mismatched sRNA-mRNA combinations while allowing matched sRNA-mRNAs to form stable pairs. Kudos to Jorjethe Roca and Yi-Lan Chen for their fantastic work!
pnas.org
Small noncoding RNAs (sRNAs) regulate gene expression in Escherichia coli bacteria in response to diverse stimuli in the environment and the host. ...
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New paper alert! We used optical tweezers to resolve heterogenous folding/unfolding pathways of repeat expanded huntingtin mRNA, revealing how hairpin slippage can seed inter-strand base pairing and promote aggregation. Congrats @NothinBut_Brett! 👏👏
nature.com
Nature Communications - Mechanical unfolding of huntingtin mRNA with optical tweezers reveals how CAG repeat expansion triggers base pair reshuffling and favors RNA aggregation that is a hallmark...
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Congrats Daniel and Elise! Check out our new story about how the structure of the glmS ribozyme has evolved to avoid non-native tertiary contact interfaces 👇👇
Excited to share our new #ribozyme paper in @NAR_Open! We used activity assays, high-throughput sequencing & all-atom MD to show that the evolution of the glmS ribozyme is constrained by a need to avoid non-native helix interfaces! #RNA @woodson_lab
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Congratulations to Dr. Yuan Lou for a fantastic thesis defense! 🎉🎉 She is an exceptional scientist and colleague, and we will miss her dearly. Best of luck at Genentech!
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Congrats Elise!! 👏👏
I’m honored to have been awarded the NIH F31 Ruth L. Kirschstein National Research Service Award (NRSA) fellowship from @NIAIDTraining! So thankful to my awesome mentor @woodson_lab for all her support & guidance. Go RNA (and Hfq)! #WomenInSTEM #Gotthegrant 👩🔬🧬
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Congrats Ewelina! Check out our new #singlemolecule story that shows how Hfq-sRNA complexes conduct a 1D scan of target mRNAs👇👇
Exciting news from @NatureComms: bacterial mRNAs are scanned for RNA-guided regulation. Hfq binds mRNA using one surface and compacts it using another. This way Hfq transfers an sRNA between different target sites within a single mRNA!
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Congratulations, Yumeng!! Check it out👇👇
Finally got this manuscript out, where we did time-resolved footprinting to understand RNA folding in real time. Thanks for @woodson_lab for support!
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Happy holidays from our lab to yours! We had a blast participating in the biophysics department’s door decorating contest! ❄️❄️
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Excited to share our new #singlemolecule #riboswitch paper! We study the co-transcriptional folding kinetics of the glmS ribozyme riboswitch and how it allows a rapid response to metabolite for mRNA turnover. Congrats Yuan! @NAR_Open
https://t.co/Rpa9NzkvOi
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🚨🚨Join us for the 7th Meeting on Regulating with RNA in Bacteria & Archaea in St. Petersburg, FL, Sept 5-8! Topics include #smallnoncodingRNAs, #generegulation, #transcription, #bacterialpathogenesis, #evolution, #CRISPR and more. Register here: https://t.co/UjObA5HOYP
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Registration is now open for the 2023 GRC @GordonConf on RNA Nanotechnology! We have a fantastic line-up of speakers on RNA structure, imaging, diagnostics, nanostructures, exosomes and therapeutics. Submit your abstract now for a short talk or poster: https://t.co/jbXoBZMwfJ
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The Woodson lab is honored to be recognized by this award named for the great nucleic acid biophysicist Nacho Tinoco!
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New #singlemolecule #RNA #RBP paper alert!🚨 We examine the molecular mechanism for how so many different sRNAs could share the same RNA chaperone Hfq to allow bacteria to respond to a wide variety of stresses. Congrats Jorjethe!! 👏👏@NatureComms
https://t.co/z7fpHu4XW4
nature.com
Nature Communications - Bacterial sRNAs compete for limited copies of an RNA chaperone. Here, real-time single-molecule imaging shows that pairwise interactions of sRNAs with Hfq determine if the...
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Please join us in beautiful Boulder, Colorado for #RNA2022! May 31-June 5, with keynotes Joan Steitz @SteitzLab @YaleRNA & Venki Ramakrishnan @MRC_LMB! Oral abstracts due March 4th & poster abstracts due March 18th. Register today! https://t.co/4hKapMBbnM
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This NEW Molecular Microbiology Special Issue looks at "Regulating with RNA in #Microbes." 👥 Edited by: Kai Papenfort, Sarah A. Woodson, Ruth A. Schmitz, Wade C. Winkler. Get stuck in: https://t.co/zVmmfM8s3q
@MolMicroEditors
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Prices for radionuclides are astronomical! For 2022, the list prices have increased by 40-120% from 2021 and an as added gut punch, our academic discounts have gone down by 10%! Grant budgets haven't increased in years - wondering how we continue the science??🤔@PerkinElmer
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