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Jean-Paul Armache Profile
Jean-Paul Armache

@valendraica

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Assistant professor at Penn State University. Opinions my own.

Joined June 2017
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@valendraica
Jean-Paul Armache
18 days
RT @MissAgataStar: Absurd po polsku czyli rekrutacja doktoranta po studiach w USA. Na doktorat aplikuje do nas człowiek, który skończył 5-….
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@valendraica
Jean-Paul Armache
3 months
We coupled in depth mutagenesis and biochemistry with high-resolution cryoEM, obtaining maps ranging from 2.37 to 2.9 Å. This work was done by Ilana Nodelman (Bowman lab) and Heather Folkwein (Armache lab). Thank you to everyone involved. It was a fun joint-venture!
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@valendraica
Jean-Paul Armache
3 months
New collaborative paper between JPArmache and Bowman (@BowmanLab_JHU ) labs show how the yeast CHD1 chromatin remodeler depends on activator elements to distort nucleosomal DNA. This explains how the NegC inhibitor blocks activity.
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nature.com
Nature Structural & Molecular Biology - Nodelman, Folkwein et al. define a regulatory region in Chd1 containing adjacent inhibitor and activator elements that compete for binding to the...
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@valendraica
Jean-Paul Armache
3 months
New collaborative paper between JPArmache and Bowman (@bowmanlab_jhu) labs show how the yeast CHD1 chromatin remodeler depends on activator elements to distort nucleosomal DNA. This explains how the NegC inhibitor blocks activity.
Tweet card summary image
nature.com
Nature Structural & Molecular Biology - Nodelman, Folkwein et al. define a regulatory region in Chd1 containing adjacent inhibitor and activator elements that compete for binding to the...
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@valendraica
Jean-Paul Armache
7 months
This was a highly collaborative work between multiple labs, performed by a talented grad student in the Armache and Murakami labs, Natalie Smith. Thank you to all the authors for their incredible work!.
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@valendraica
Jean-Paul Armache
7 months
We did a thing. We purified native transcriptional complexes from Drosophila embryos, obtaining +/- stalk Pol II elongation complexes, native nucleosomes, as well as a nucleosome elongation complex. For more details please check out:
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@valendraica
Jean-Paul Armache
9 months
Cool stuff :) Congratulations to all the authors, it’s been an awesome experience to work with you.
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@valendraica
Jean-Paul Armache
10 months
RT @simonduerr: This is great! @NIAIDNews have launched a collection of public domain illustrations (currently 550 individual icons) https:….
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@valendraica
Jean-Paul Armache
1 year
Congratulations, Stephen! Well-deserved!.
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@valendraica
Jean-Paul Armache
1 year
Thank you for hosting me, I had a great time!.
@CeiFccc
@CEI-FCCC
1 year
The @CeiFccc #NEXTepiGEN seminar series featuring #AssistantProfessors leading the future for #epigenetics and #chromatin field is today. @valendraica from @cegrPSU showed amazing #CryoEM for chromatin enzymes! A great talk @FoxChaseCancer @CeiFccc. Thanks for visiting us!
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@valendraica
Jean-Paul Armache
1 year
Clouds made it an almost impossible task to see the eclipse, but the resulting pictures have a bit of a mood…. Wojciech Kilar’s music to Bram Stoker’s Dracula would have been a perfect soundtrack for that 🤭
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@valendraica
Jean-Paul Armache
2 years
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@valendraica
Jean-Paul Armache
2 years
English question, non-native speaker here:. When a line crosses an axis, it is called ‘interception’. When two lines meet or cross, it is called ‘intersection’. Wouldn’t that mean that the term ‘intercept’ and ‘intersect’ are exchangeable for a line crossing an axis?.
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@valendraica
Jean-Paul Armache
2 years
RT @FilippDM: I imagine this may go unnoticed outside Poland, so I`d like to give heads up to all of you interested in the rather never off….
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@valendraica
Jean-Paul Armache
2 years
‘Here we report a structure of an unusual, square nucleosome. It’s totally legit and not a bug. But even if it were a bug, look how pretty!’ 🤭
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@valendraica
Jean-Paul Armache
2 years
Another awesome work from the @KJArmache lab and collaborators. Heartfelt congratulations to everyone, especially the first author, Stephen Abini-Agbomson @Xagbomson!.
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@valendraica
Jean-Paul Armache
2 years
Congrats to all the authors, amazing work!.
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@valendraica
Jean-Paul Armache
2 years
Great work from the @KMurakamiLab with some contribution from our lab.
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@valendraica
Jean-Paul Armache
2 years
RT @HaoYin20: #CryoEM structure of👤#Sirt6–nucleosome complex. Sirt6-H2A tail interaction as a potential inhibitory state. Design histone-bi….
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@valendraica
Jean-Paul Armache
2 years
Penn State's write-up (thank you to @scissorsfiend!)
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