Matthew Tay
@tzmatthew
Followers
27
Following
3
Media
2
Statuses
12
Vaccinologist at A*STAR ID Labs in Singapore using microfluidics to characterize antibodies and antigens against viruses and other infectious diseases.
Singapore
Joined July 2010
RT @VignuzziLab: Matthew Tay presents an overview of his lab’s research on characterizing coronavirus antigenic landscapes and using mutati….
0
1
0
RT @ceri_news: #Chikungunya: A growing public health crisis😷 With >120,000 cases, 51 deaths in 2023; 46 in #Paraguay. This study used a s….
0
8
0
Generate videos in just a few seconds. Try Grok Imagine, free for a limited time.
508
942
4K
Is it a tall order to do biologic therapeutics discovery, Pk analysis, and meta-analysis of 2000 studies to show its importance in treatment? This is one of the SCI-PHI projects built at @nuspharmacydept by 6 ambitious undergrads - proud to be one of their mentors. #NUSPharmacy.
0
0
0
Resonated: “Something that's really tough for people in the USA to really understand is that in Singapore, you can have 40, 50-year plans. So you can really do some amazing things. Whereas in the US, you're always thinking about two-year election cycles.”.
forbes.com
Singapore's recruitment of talent, billions in investment, top universities, and attraction of venture capital makes it an exciting emerging hub for biotech innovation.
0
0
1
mAbs among the approaches for protecting us against the next pandemic. But can we generate mAbs that protect not just against sarbecoviruses or betacoronaviruses, but also all other coronaviruses?. #Coronavirus #SARSCoV2.
science.org
U.S. government project bets big on intranasal vaccines and monoclonal antibodies, but omits more ambitious approaches
0
0
1
COVID-19 increased antibody responses against all orrhocoronaviruses, albeit at low levels. How does this affect our protection against additional zoonotic coronaviruses? . #tayterthoughts #SARSCoV2.
medrxiv.org
The Orthocoronaviridae subfamily is large comprising four highly divergent genera. Four seasonal coronaviruses were circulating in humans prior to the coronavirus disease 2019 (COVID-19) pandemic....
0
0
0
ACE2 decoys (but not Spike-directed peptides) are broad neutralizers of SARS-CoV-2. But they may need to be tuned to increase their in vivo efficacy. #tayterthoughts #SARSCoV2 #Omicron
0
0
1
229E coronavirus: .Spike takes ~8 years to mutate 1%.RBD takes 2 years to mutate 1%(. SARS-CoV-2: .Spike takes 1 year to mutate 1%.RBD takes 4 months to mutate 1% .(calculated based on WT, BA2, XBB1.5). SARS-CoV-2 mutates 6-8x faster. #tayterthoughts.
journals.plos.org
Author summary Hopes for controlling SARS-CoV-2 rely on vaccination or infection to confer immunity that protects against subsequent infection. However, the “common-cold” seasonal coronaviruses...
0
0
0
Machine learning and language models may be able to predict future SARS-CoV-2 variants. What biological (ACE2 affinity/immune escape parameters) or epidemiological data inputs are required to train good models? . #tayterthoughts.
pubmed.ncbi.nlm.nih.gov
SARS-CoV-2 evolution threatens vaccine- and natural infection-derived immunity as well as the efficacy of therapeutic antibodies. To improve public health preparedness, we sought to predict which...
0
0
1
Memory B cells are selected based on low affinity to antigen, i.e. failure to continue in the germinal center, in order to preserve cross-reactivity to different pathogen variants. #tayterthoughts
0
0
0
I’m #hiring! Looking to do antibody-based therapeutics against infectious disease, including potentially AACs. See our website and contact for details :)
antimicrobialbiologicslaboratory.com
0
0
0
RT @jbloom_lab: I wanted to summarize what is known about the new XBB.1.5 variant of SARS-CoV-2, which is starting to generate a lot of int….
0
1K
0