Tom Chartrand
@tmchartrand
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neuroscience, data, math & computation @alleninstitute.
Seattle, WA
Joined November 2016
(and yes, I'm guilty of only tweeting papers😥. Sorry all, I'll try to learn sustainable engagement here soon, just in time for the platform's impending demise!)
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More once we're through review - for now, feedback is welcome, including at our poster at #SfN22 4/4
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Dive in for some updates on rosehip cells and other unusual cell types, along with insights into cross-species alignment and divergence in a super diverse part of cortex relevant to state modulation, learning, feedback and more!
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Along w/ its companion https://t.co/c3RsspMkaI this is the culmination of a huge team effort at @AllenInstitute and internationally (@blee_aibs @alice_mukora @Delissa76 @jimbergbrain @staci_sorensen @gouwens @Jennie_L_Close...)
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A couple weeks ago we quietly released a draft characterizing inhibitory neuron types in layer 1 of human cortex using patch-seq, and comparing to mouse! (w/ @KalmbachsCortex and many others)
biorxiv.org
Neocortical layer 1 (L1) is a site of convergence between pyramidal neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary...
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(disclaimer: 🐁 and 🤵 are different in many ways, so let’s not assume these findings are related to intelligence or human-unique. Who knows what we’d find in other species!) 7/7
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Other interesting species contrasts: human neurons recover faster from depression and have less variable responses. 6/7
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These layers of cortex are dramatically expanded in primates - these new observations can help us understand what our brains might be doing with that extra tissue. None of these interesting properties are found in our mouse data. 5/7
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We also confirmed disynaptic inhibition observed by G. Tamas (chain of two connections, + then -) and showed it often proceeds from superficial L2 to deeper L3. 4/7
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Synaptic data showed that these cells have different connections too! Deep L3 cells are less connected to adjacent layers and show more depression (weaker response over time). 3/7
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This was a chance to follow up on past work with @staci_sorensen, @jimbergbrain, where we found unique types of neurons in one part of human cortex (deep layer 3). https://t.co/Nlc1i1rbLT 2/7
nature.com
Nature - Combined patch clamp recording, biocytin staining and single-cell RNA-sequencing of human neurocortical neurons shows an expansion of glutamatergic neuron types relative to mouse that...
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On the Human Cell Types team, we study single neurons from tissue removed during surgery (thanks donors 🙏). We don’t usually get to study connections, so I jumped in to help with our SynPhys team’s analysis ( https://t.co/DvY5xxuexT). 1/7
science.org
The temporal dynamics of interneuronal connections and local connectivity are analyzed in mouse and human brain slices.
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Just out in Science! Happy to have contributed to this project with @docseeman @lukecampagnola @timjarsky, thanks y'all.
🧠 Which brain cell types are connected, and what do those connections look like? 🤔 Recording from multiple live neurons simultaneously — our researchers mapped thousands of cortical connections to find out. 🧵 1
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restarting this account, hello hello. will be tweeting about exciting science soon!
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