Tomer Lapidot
@tlapidot28
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Postdoctoral research fellow of pooled optical screens and bioimformatics @ophirshalem Lab @PennGenetics @ChildrensPhila
Philadelphia, PA
Joined July 2023
Our platform for rapid manipulation of endogenous proteins at scale #SPOTLITES can be employed to discover novel effectors for #targetedproteindegradation #TPD and other proximity-based approaches! https://t.co/hcdjiFFKYw
biorxiv.org
The field of induced proximity therapeutics is in its ascendancy but is limited by a lack of scalable tools to systematically explore effector-target protein pairs in an unbiased manner. Here, we...
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I'm really excited to present work from @ophirshalem’s group with my outstanding co-first author Yevgeniy Serebrenik @YSereb to tag and manipulate proteins at scale, which we use to study the #proteome and #proteostasis
biorxiv.org
System-level understanding of proteome organization and function requires methods for direct visualization and manipulation of proteins at scale. We developed an approach enabled by high-throughput...
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Happy to share two preprints where we demonstrate Scalable POoled Targeting with a LIgandable Tag at Endogenous Sites (#SPOTLITES) for protein imaging, perturbation and recruitment. Led by v v talented @YSereb and @stephsansbury
https://t.co/AnZT04t2Hl
https://t.co/n8mqxLvIRX
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Fantastic collaboration with @GMBurslem lab. Special mention for @tlapidot28 for excellent and extensive computational work and high throughput image analysis and Deepak Mani that led many of the experiments in the recruitment paper
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#SPOTLITES (‘Scalable POoled Targeting with a LIgandable Tag at Endogenous Sites’) would not exist without our fantastic co-authors @tlapidot28, @GMBurslem, and @ophirshalem. Thanks also to CHOP's CAG sequencing core, the optical sequencing community, and our wonderful labmates!
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