Tim Yu
@timcyuu
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phd student @mcbseattle in the @jbloom_lab wondering how viruses evolve
Seattle, WA
Joined July 2019
RT @jbloom_lab: In new study led by @timcyuu, we measure how mutations to H3 flu HA affect cell entry, stability & antibody escape. We find….
biorxiv.org
The evolution of human influenza virus hemagglutinin (HA) involves simultaneous selection to acquire antigenic mutations that escape population immunity while preserving protein function and stabil...
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RT @jbloom_lab: In study led by @CKikawa & Andrea Loes, we use new assay to measure ~10,000 neutralization titers to recent influenza strai….
biorxiv.org
Human influenza viruses rapidly acquire mutations in their hemagglutinin (HA) protein that erode neutralization by antibodies from prior exposures. Here, we use a sequencing-based assay to measure...
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Congrats @gracecbower!.
Beyond proud of the work that went into our latest story! A big shoutout to @evgenykvon for the incredible guidance.
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RT @evgenykvon: How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by @gracecbower where w….
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RT @jbloom_lab: In new study led by @bdadonaite, we measure how all mutations to H5 influenza HA affect four molecular phenotypes relevant….
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RT @jbloom_lab: In new study led by @bblarsen1 in collab w @veeslerlab @VUMC_Vaccines we map functional & antigenic landscape of Nipah viru….
biorxiv.org
Nipah virus recurrently spills over to humans, causing fatal infections. The viral receptor-binding protein (RBP or G) attaches to host receptors and is a major target of neutralizing antibodies....
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RT @jbloom_lab: In new study led by Andrea Loes, we develop sequencing-based neutralization assay that measures replicate curves for hundre….
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RT @jbloom_lab: In new study led by Caleb Carr & @khdcrawford, we measure how all mutation to Lassa virus glycoprotein complex (GPC) affect….
biorxiv.org
Lassa virus is estimated to cause thousands of human deaths per year, primarily due to spillovers from its natural host, Mastomys rodents. Efforts to create vaccines and antibody therapeutics must...
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RT @jbloom_lab: In new study led by Frances Welsh, we map how mutations to influenza affect neutralization by antibodies from humans of var….
biorxiv.org
Human influenza virus evolves to escape neutralization by polyclonal antibodies. However, we have a limited understanding of how the antigenic effects of viral mutations vary across the human...
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RT @JKulsuptrakul: Thrilled to announce my first first-author paper of grad school has been accepted at @eLife! Shoutout to @turcotteea, my….
elifesciences.org
HIV-1 infection activates the human CARD8 inflammasome via innate immune recognition of HIV-1 viral protease activity.
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RT @jbloom_lab: In a new study led by @CaelanRadford in collaboration with @FKlein_lab, we use an improved deep mutational scanning system….
biorxiv.org
Understanding the specificities of human serum antibodies that broadly neutralize HIV can inform prevention and treatment strategies. Here we describe a deep mutational scanning system that can...
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RT @jbloom_lab: Final version of our paper on deep mutational scanning system to measure antigenic and functional effects of mutations to f….
cell.com
A high-throughput deep mutational scanning platform that uses non-replicative pseudotyped lentiviruses is able to directly quantify how SARS-CoV-2 spike mutations affect antibody neutralization and...
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RT @jbloom_lab: In work led by @bdadonaite @khdcrawford @CaelanRadford, we develop pseudovirus system to deep mutational scan full #SARSCoV….
biorxiv.org
A major challenge in understanding SARS-CoV-2 evolution is interpreting the antigenic and functional effects of emerging mutations in the viral spike protein. Here we describe a new deep mutational...
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RT @JKulsuptrakul: First manuscript of grad school now live on bioRxiv! Check it out ;) So excited and thankful to @psmitchej and @memerman….
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RT @tylernstarr: Our newest study is up, where we report deep mutational scanning data in the Omicron BA.1 and BA.2 receptor-binding domain….
biorxiv.org
SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD) that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep mutational scanning prospec...
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Excited to share our preprint on modeling viral escape from polyclonal antibodies. Check out the thread by @jbloom_lab for more details!.
In new work, we formulate a biophysical model of viral escape from polyclonal antibodies, & develop software to apply model to deep mutational scanning data to understand antigenic effects of combinations of mutations: I explain in 🧵 below.
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RT @jbloom_lab: In new study, we examine how target cell ACE2 expression affects #SARSCoV2 neutralization We find….
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RT @jbloom_lab: In new study led by @dbacsik, we show single influenza-infected cells produce wildly different numbers of viral progeny: ht….
biorxiv.org
The ultimate success of a viral infection at the cellular level is determined by the number of progeny virions produced. However, most single-cell studies of infection quantify the expression of...
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RT @tylernstarr: 🥳 Excited to share that the Starr Lab is coming to the University of Utah @UofUBiochem! Check out the lab website to see w….
starr.biochem.utah.edu
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RT @jbloom_lab: We have new data on the effects of all RBD mutations to Omicron BA.1 and BA.2 on ACE2 affinity & RBD expression. These data….
jbloomlab.github.io
Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution.
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