T&F Channels
@tandfchannels
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Channels (EIC Gerald Zamponi) publishes papers on ion channel and transporter/exchanger function, biophysics, pharmacology and regulation in health and disease.
Joined November 2021
Chai et al., show that the glucose transporter SLC2A3 can predict the prognosis of head and neck squamous cell carcinoma (HNSC) patients and mediate the progression of HNSC via the NF-κB/EMT axis and immune responses ▶️ https://t.co/vFJmVehNlM
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In this Review, David Spafford dives (deep) into the structural determinants governing the selectivity of #ionchannels ▶️ https://t.co/P6jN5Y9ZLj
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In this study, Zhuqing Xie and Nashat Abumaria identified the shortest structure of #TRPM7 #ionchannels necessary for channel activity https://t.co/sW1UoeLztw
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New Research paper: Characterization of two pathological gating-charge substitutions in Cav1.4 L-type calcium channels #ionchannels #channelopathies ➡️ https://t.co/5AS4UjUGkT
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New Review article - SLC26A9 in airways and intestine: secretion or absorption? https://t.co/X7vUB4unQM
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New Review from Anjali Rajadhyaksha' lab @RajadhyakshaLab - L-type #calcium #ionchannels and neuropsychiatric diseases: Insights into genetic risk variant-associated genomic regulation and impact on brain development #channelopathies
tandfonline.com
Recent human genetic studies have linked a variety of genetic variants in the CACNA1C and CACNA1D genes to neuropsychiatric and neurodevelopmental disorders. This is not surprising given the work f...
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New Review article from the Dolphin lab @AnnetteCDolphin: "The importance of cache domains in α2δ proteins and the basis for their gabapentinoid selectivity" #ionchannels ➡️ https://t.co/QoV09MyMZx
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New Review article: "Advances in Cav1.1 gating: New insights into permeation and voltage-sensing mechanisms" #ionchannels ➡️ https://t.co/ktxud6KY0p
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We are thrilled to have this line up of fantastic people to join the editorial team of @tandfchannels as Early Career Editors 🙏 We believe everyone will benefit from this!
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John Husseya, Worawan Limpitikulb, and Ivy Dick @IvysLab inaugurate the 2023 issue of @tandfchannels with this fantastic review of the pathophysiology of #calmodulin #calmodulinopathies #channelopathies ➡️ https://t.co/Og0PLMUAcc
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Association of respiratory failure with inhibition of NaV1.6 #ionchannels in the phrenic nerve
tandfonline.com
As part of a drug discovery effort to identify potent inhibitors of NaV1.7 for the treatment of pain, we observed that inhibitors produced unexpected cardiovascular and respiratory effects in vivo....
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Pleiotropic Ankyrins: Scaffolds for Ion Channels and Transporters by Sharon R. Stevens & Matthew N. Rasband @MattRasband ➡️ https://t.co/lCf2yvw2NU
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New research paper - Hippocampus-related cognitive disorders develop in the absence of #epilepsy and #ataxia in the heterozygous Cacna1a mutant mice tottering
tandfonline.com
CACNA1A-associated epilepsy and ataxia frequently accompany cognitive impairments as devastating co-morbidities. However, it is unclear whether the cognitive deficits are consequences secondary to ...
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New research paper - Mechanism of carvedilol induced action potential and #calcium alternans
tandfonline.com
Carvedilol is a nonspecific β-blocker clinically used for the treatment of cardiovascular diseases but has also been shown to have profound effects on excitation-contraction coupling and Ca signali...
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New research paper - #Capsaicin as an amphipathic modulator of NaV1.5 mechanosensitivity ➡️ https://t.co/SoeqHuQOCA
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New research paper on the importance of #TRPV #ionchannels to prognosis and immune infiltration in kidney #cancer
tandfonline.com
The transient receptor potential vanilloid (TRPV) family has been preliminarily discovered to play an important role in various cancers, including clear cell renal cell carcinoma (ccRCC), which is ...
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New research paper on the molecular mechanisms of Kv4.3 #ionchannels inhibition by the JZTX-V toxin
tandfonline.com
JZTX-V is a toxin isolated from the venom of the Chinese spider Chilobrachys jingzhao. Previous studies had shown that JZTX-V could inhibit the transient outward potassium current of Kv4.2 and Kv4....
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New commentary on the landscape of hyperpolarization-activated cyclic nucleotide-gated (#HCN) #ionchannels research (2004-2020) ➡️ https://t.co/m7QLvzEQJM
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New article - Clinical and molecular characteristics of myotonia congenita in China: Case series and a literature review #ionchannels #ClC-1 #channelopathies ➡️ https://t.co/y4KMdI6PMK
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New review from Eric E. Figueroa & Jerod S. Denton - A SWELL time to develop the molecular pharmacology of the volume-regulated anion channel (VRAC) ➡️ https://t.co/6BUD874wqr
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