Sudarshan Dayanidhi
@sududay78
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Scientist/Assistant Professor @AbilityLab @NorthwesternU... Satellite Cells, Muscle Mitochondrial Function, Cerebral Palsy, All Science
Chicago, IL
Joined July 2016
Was great to present some of our collaborative work on PBMCs. More questions than answers!.
At the @WorldAbilitysp conference. Great interactions with colleagues and always fun to share new data. Super talks delivered by @sududay78 and @linneaacorell !
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RT @AJPCellPhys: Check out this #DecodingFibrosis Review from our latest issue. Alignment, cross linking, and beyond: a collagen architect’….
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Great to be part of this review by @RyanKahn12 (& Orly Lacham-Kaplan and @JohnAHawley) setting the stage for his PhD studies.
As part of our Cellular and Tissue Clocks Reviews, Ryan E. Kahn et al. (@ACUmedia) authored this piece in our latest issue, Molecular clocks, satellite cells, and skeletal muscle regeneration:. #CellCycle #CircadianRhythm #StemCells
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Was really great to come back to the (ny) Karolinska Institutet (& Solna) after many years to give a talk on our current research in metabolism in children with CP. Tack så mycket @FerdinandvW
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I was lucky enough to do a @ResearchworksP podcast @EACD2023 on some of our mitochondrial work in kids with CP (& some broader discussions).
Some smokin hot knowledge from my dear friend and colleague @sududay78 spreading the importance of physical activity for muscle bioenergetics in kids with CP! Looking forward to having you over to @karolinskainst this week!.
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RT @RyanKahn12: Very excited to share our recent review and part of the first chapter of my PhD on satellite cell molecular-clock regulatio….
journals.physiology.org
Skeletal muscle comprises approximately 50% of individual body mass and plays vital roles in locomotion, heat production, and whole body metabolic homeostasis. This tissue exhibits a robust diurnal...
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RT @VMJ_SVM: In this study, Guo et al. find that cigarette smoking may stimulate mitochondrial biogenesis to compensate for reduced oxidati….
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Thank you for the honor!.
🏅Congratulations to Dr. Sudarshan Dayanidhi et al. for their #APSselect article “Resident muscle stem cell myogenic characteristics in postnatal muscle growth impairments in children with #CerebralPalsy”. @sududay78 @RyanKahn12
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Finally, we show our manual quantification and MuscleJ quantification were similar and were significantly associated with each other.
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We also report that non-contractured muscles in children with CP was not similar to typical developing children with a chronic musculoskeletal injury (torn ACL), with lower abundance across fiber types in those with CP.
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Oddly, we did not find any significant differences in MuSC and myonuclear characteristics in contractured or non-contractured muscles between primarily ambulatory (GMFCS I, II, III) and minimally ambulatory (GMFCS IV,V) children.
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We found associations between MuSC abundance, myonuclear number and fiber cross-sectional area only in contractured muscles, suggesting an ongoing establishment or alteration of MuSC pool.
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Myonuclear number was similar in contractured and non-contractured muscles, suggesting myonuclear accretion early in life occurred even in muscles that develop contractures. Type-2 fibers had greater myonuclear number in contractured muscles but not in non-contractured muscles.
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Extracellular matrix collagen (fast green, sirius red staining) was lower in contractured muscles compared to non-contractured muscles. Intriguingly, in CP muscle collagen content was negatively associated with MuSC abundance and positively with MuSC activation, proliferation.
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However these MuSCs showed lower percentage of activated (Pax7+/MyoD+) and proliferating (Pax7+/Ki67+) cells, i.e. reduced myogenic characteristics.
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In situ contractured muscles had a greater abundance of muscle stem cells (MuSC), particularly in type-1 fibers compared to non-contractured muscles.
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We found that in children with CP contractured muscles (gastroc, adductors) showed impaired muscle growth, i.e. smaller and higher frequency of smaller muscle fiber compared to non-contractured muscles (vastus lateralis) and children with typical development with a torn knee ACL.
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Really honored that our work led by @RyanKahn12 was among those chosen for APSselect for this month. Our article is free to read for the next couple of months @AbilityLab @NUFeinbergMed @NUPTHMS @LurieChildrens.
Congratulations to @AJPCellPhys March #APSselect winners @RyanKahn12, @sududay78 et al. for their article “Resident muscle stem cell myogenic characteristics in postnatal muscle growth impairments in children with cerebral palsy” @AbilityLab .
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RT @APSPhysiology: "Dazzling scientific results aren’t, on their own, necessarily meaningful to patients. So, @MonicaPerezPhD vowed to keep….
physiology.org
Dazzling scientific results aren’t, on their own, necessarily meaningful to patients. So, Monica Perez, PT, PhD, vowed to keep working.
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