One of our lab assistants made me melanoma cookies as a parting goodbye. I was touched.

What do you want to know?.

Should we be using the Her2 IHC 0+ designation, even though the concordance among pathologists (0 vs 0+ is not very good. 0+ is defined as faint membrane staining in >0 but ≤10% of tumor cells (so-called Her2 ultralow).

From a BCC excision. BCC, mantleoma/mantle, basaloid hamartoma?

Nodular type basal cell carcinoma should be split up into two types. BCC, small nodular type (on the left) and BCC, large nodular type (on the right). To me, the picture on the left is different than so-called micronodular BCC, but that is debatable.

Seborrheic keratosis or Epidermal change over a DF. Most likely the latter. Can you guess the location?

A. Both BCC.B. Left BCC, right trichilemmoma .C. Both trichilemmoma .D. Left trichilemmoma and right BCC

If a sentinel node is negative on a pT2a or greater melanoma, what is the likelihood of having positivity if an added 2 deeper (level) tissue sections and IHC were evaluated. I would venture it is greater than 5% depending on various factors. If so, why aren't we doing that?.

Anyone know of a lab that performs IHC for Monkey pox?.

Melanoma cytology

Is there such a thing as a pelvic lipoma. Urologist use this term when performing prostatectomies. That is, right and left pelvic lipomas. Sounds suspicious that they are just making up that clinical diagnosis to clear away fat to remove lymph nodes? Thoughts?.

Good upcoming article in J Cutan Pathology.

Requirements which should be removed in the reporting of melanoma .1. Clark level .2. Tumor infiltrating lymphocytes.3. Regression .Radial/vertical growth phase (not a req) but some mention it. Present/absent solar elastosis (not a req), but some mention it. Agree/disagree?.

There are several different manifestation of psoriasis. Is psoriasis one dz or multiple diseases? That is, will there ever be a time when we combine the clinical with histology with molecular/proteinomic info. That is, you have psoriasis, type 1 or psoriasis type 2, etc.

Thoughts on this finding within the myometrium. What IHC stain/s would you order?

In benign pelvic fluid specimens that are cellular in which you can't tell if the cells are mesothelial cells or histiocytes, or a combination of the two, what is the most appropriate cytologic diagnosis?.

A few more pics.

Solitary lesion on the knee in an adult. Your diagnosis is: A) Hidradenocarcinoma .B) Primary cutaneous cribriform carcinoma/tumor .C) Primary cutaneous apocrine carcinoma .D) Metastatic carcinoma .E) Benign adnexal/sweat gland tumor

Just a pretty picture

Is there anyone other than Mayo clinic who does mass spectroscopy for amyloid? Commercial testing.

A blob of dystrophic calcification within a nevus. If Nanta can do it with bone, I think I do it with this calcification. I will call it Nevus of Kolker