Stephanie Orchanian
@stephorch
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UCLA Chancellor’s Postdoctoral Fellow at UCLA
Joined October 2009
Excited to share our recent publication in this month's issue of mBio, based on my PhD research. We show that replication of 𝘛. 𝘨𝘰𝘯𝘥𝘪𝘪 is required to trigger a localized immune response in the brain! 🧠
journals.asm.org
Toxoplasma gondii is a brain-infecting parasite, and the mobilization of peripheral immune cells to the brain is critical for controlling T. gondii infection. However, the initial events driving...
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Happy to share our work on hippocampal inflammasome signaling. Thank you to members of the lab for critical experimental support, @BIG_Center_UVA colleagues for input, and @LukensJohnR for baller mentorship - it's been an honor working with you all!
cell.com
The function of immune pathways in homeostatic neurobiology remains underexplored. Zengeler et al. find that the inflammasome complex, typically associated with immune responses, is involved in...
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Thrilled to share this collaborative work by Kristie Yu, Francis Chandra, Amina Schartup and teams @Scripps_Ocean and @UCLA showing that an engineered gut bacterium can reduce the neurotoxic effects of dietary methylmercury
cell.com
Yu and Chandra et al. engineered a commensal gut microbe, Bacteroides thetaiotaomicron, to detoxify methylmercury (MeHg). The engineered bacterium reduces MeHg in the intestinal lumen, limits its...
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Maternal microbiome is a cornerstone of maternal and fetal health. @stephorch & @pipethero @UCLA highlight gut microbiome x environmental interactions at the maternal-fetal interface that influence the brains of pregnant people & developing offspring: https://t.co/bnUtPWmQ7q
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Curious about how the gut microbiome modulates the neurological health of pregnant women and their offspring? Check out my recent review with @pipethero out now @jclinicalinvest! 🦠🤰👶🧠 https://t.co/Gqz3q8SK7R
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Excited to announce that the MinD-Gut Lab is kicking off in 2025, and we’re already looking for PhD students to join our research team @LSUAgCenter!! Please contact us! Check out the Nutrition and Food Science PhD program at LSU!
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Grad students and postdocs, the 2025 GRS: Neuroimmune Communication in Health and Disease in Lucca, Italy, has reached over 70% acceptance capacity! If you're interested in attending, sign up soon at https://t.co/y0QQ5op2jC.
@yan_zhaoqi and I look forward to seeing you there! 🧠
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The MinD-Gut lab will open in Jan 2025 at the School of Nutrition and Food Sciences of @LSUAgCenter to investigate the science of microbe and diet interactions in gut-brain connection. Motivated humans to study nutrition-gut-brain communication in the heart of LA come this way
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Grad students and postdocs- Registration for the 2025 GRS: Neuroimmune Communication in Health and Disease in Lucca, Italy is officially open! Spots are limited so sign up soon at https://t.co/y0QQ5op2jC!
@yan_zhaoqi and I look forward to seeing you there! Please RT!
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Excited to announce that I was selected by the UC President’s Postdoctoral Fellowship Program and, starting today, am ~officially~ a UCLA Chancellor’s Postdoctoral Fellow!🥳Thank you to everyone who supported me in this especially #UCLARiseToTheChallenge and my PI @pipethero! 🙌🏼
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Excited to share this paper in final form, now with more supporting experiments in supplement and main figs! https://t.co/3fxcRQ90Jr Many thanks to @PingFan78765311 and colleagues for their hard work and dedication through this journey.
Happy to share new work by @PingFan78765311, @EspeyHannah, Lewis Yu, @GulistanAgirman, @zachlee_2008 & colleagues exploring links between early GI symptoms + risk for PD -- an interesting example of a sex-biased gut-brain GxE interaction!
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For the AAI attendees interested in #neuroimmunology and #neurodegeneration, come stop by my poster to talk about microglial SYK signaling in tauopathies! I am poster number B621 on May 5th 🧠🦠
Don't miss the dynamic IMMUNOLOGY2024™ poster sessions! Network with authors and learn about cutting-edge advancements in immunology. Odd numbered poster sessions begin at 11:30 am in the exhibit hall. #AAI2024
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I couldn’t call myself a microbiologist if I went to Amsterdam and DIDN’T stop at #Micropia. Although I couldn’t find 𝑇. 𝑔𝑜𝑛𝑑𝑖𝑖, I did find another Apicomplexan parasite! Can you tell which one? 👩🏻🔬🧫🔬
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Excited to share new research by Elena Coley-O'Rourke and colleagues showing that the microbiome modifies adverse effects of maternal protein undernutrition on offspring brain development and behavior!
biorxiv.org
Protein undernutrition is a global risk factor for impaired growth and neurobehavioral development in children. However, the critical periods, environmental interactions, and maternal versus neonatal...
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When you and your PI wear the same outfit at your PhD defense you know you’re ready to be a doctor!
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My PhD defense @UCIBioSci has finally arrived!!! Be sure to attend if you’re interesting in learning more about the importance of chemokine production and mechanosensation in innate immunology!
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Ever wonder how gut microbial food preferences influence host food preferences? Us too! Delighted to share work by Kristie Yu, @CelineSon11 & co on how gut bacterial metabolism of specific fibers influences host preference for diets containing those fibers
biorxiv.org
The gut microbiota interacts directly with dietary nutrients and has the ability to modify host feeding behavior, but the underlying mechanisms remain poorly understood. Select gut bacteria digest...
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What did I get for Valentine’s Day? Our article online in the Journal of Chemical Education! Read how @norchanian and I use TikTok as a science communication tool, reaching millions of students across the globe. Send to your sweetie! https://t.co/5g6YF7NVLA
pubs.acs.org
As social media platforms continue to grow in popularity, there is an increasing need for science outreach teams to bring STEM content to the virtual landscape. Here, we highlight the use of short-...
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HOT OFF THE PRESS! Check out my recent paper in collaboration with the @tajieharris lab on the role of CCL2 in neuroinflammation during 𝘛𝘰𝘹𝘰𝘱𝘭𝘢𝘴𝘮𝘢 𝘨𝘰𝘯𝘥𝘪𝘪 infection! 🧠🐭 https://t.co/JTZ0hNCrCY
journals.plos.org
Author summary Neuroinflammation plays an important role in protecting the brain against infection, but it must be controlled to prevent damage to the brain. Toxoplasma gondii is an obligate intrac...
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As we approach the conclusion of 2023, we wish to extend our heartfelt gratitude to the authors, reviewers, and readers whose unwavering support has enriched our journal throughout the year. We cordially invite you to peruse the covers of our 12 issues... https://t.co/2F8RLLnIlP
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