Juan C Serrano, MD, PhD
@serranJS
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Transitional year intern @mhshospital, future radiology resident @UCSF. Penn MSTP alum🩺🧬, Gates-Cambridge Scholar, UF grad🐊. I want to believe👽.
Coral Springs, FL
Joined June 2010
Proud to announce I’ll be going to Memorial Healthcare in South Florida for 1 year of general medicine, then University of California - San Francisco for 4 years of Diagnostic Radiology!!.Eternally grateful to my parents and family for their support since day 1. @RadsUcsf
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RT @RemiBuisson: Now online! APOBEC3A and APOBEC3B drive distinct mutational landscapes in tumors. We showed how A3A and A3B substrate pref….
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Had a great time at my first #RSNA hearing about cutting-edge radiology research and meeting colleagues as a #FutureRadRes. Wonderful to see MCCormick Place from SkyEdge as well!.@RSNA @RSNATrainees
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Thought Spanish-speaking #MedTwitter would get a kick out of this exchange with my dad. #Match2024 #RadTwitter #FutureRadRes
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RT @Jairo_I_Funez: Although the implosion of OceanGate’s Titan was heard from the very beginning and death was certain, resources were stil….
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RT @twang0518: Excited to share our paper out today in @nchembio! DM-Seq is our non-destructive approach for detecting DNA methylation. We….
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RT @muhil_ravi: My name is Muhil, and I first came to the United States when I was 2 years old. Despite living here lawfully for two decade….
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When the fellow starts ranting about med students not really learning and relying on those “sketchy cartoons”
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RT @CDR3b: @RiderToast (with phd friends) ugh clinicians am I right .(with md friends) ugh researchers am I right .(with md phd friends) my….
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RT @lachristensen: 24 days ago I learned my daughter was dying in utero, and if untreated I risked preeclampsia and stroke. Termination is….
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RT @uffdaALLberries: 1/ Excited (and relieved) to share our new work with @arjunrajlab on identifying intrinsic factors marking rare somati….
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I could not have picked a more supportive lab than the @KohliLab to pursue the PhD portion of my MD-PhD and develop my skills as a chemical biologist. Our DNA dumbbell story is yet to be over, so be on the lookout as we advance our modulators to the cellular realm!.
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These efforts could not have been possible without the strong collaboration with the @DmochowskiUPenn lab and Dora von Trentini, as well as the amazing @Berrios_KN and @AleksiaBarka.
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These DNA-based inhibitors provide a proof-of-concept for the importance of looking beyond the more obvious features of protein substrates for designing molecular probes. After all, nature has shown us time and time again that structure dictates function.
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Most importantly, we show our DNA dumbbells are specific inhibitors of A3A, as they have markedly reduced activity against closely related A3B, another oncogenic deaminase, and A3F, replicating each enzyme's mutational preference observed in nature.
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We found simply changing the shape of the DNA backbone yielded a near 35-fold improvement in activity to nanomolar-level potency, when compared to a nonstructured inhibitor. We then interrogated which inhibitor features conferred this potency and which were open to modification.
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With this insight into A3A's targeted activity on the genome, we hypothesized that by placing an inhibitory nucleobase, 5-methylzebularine (mZ), in a DNA scaffold mimicking a hairpin, such as a DNA dumbbell, we could design a more potent and specific inhibitor.
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