Sagnik Sen, M.D.
@riksag
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Retina-Uvea-Genetics | #Vitreoretina surgeon @gsttNHS @Moorfields | #MAMC @aiims_newdelhi @aravind_eyecare | #KVPYFellow| l🇮🇳🇬🇧
📍Kolkata-Delhi-Madurai-London
Joined July 2009
First of a kind deep-learning model for predicting the gene in Inherited Retinal Diseases from retinal imaging! Grateful to be a part of this amazing collaboration @UCLeye and @Moorfields ! @npontikos @william_woof .@tacguimaraes @MichelMichaelid @KonBalaskas #deeplearning #gene.
Our preprint.
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RT @NEIDirector: Next-generation phenotyping of inherited retinal diseases: Eye2Gene (AI-driven algorithm). Better-than-expert accuracy for….
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RT @SamanthaTaghoy: I suffered with an eating disorder through my teenage years. When I was 15, I spent over a month in hospital refusing….
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🎓Curious about the research behind the numbers?.Check out my Google Scholar profile here: Here’s to the next chapter of inquiry, innovation, and impact!. #AcademicLife #Research #Scholarship #GoogleScholar #Gratitude #Milestone #1000Citations.
scholar.google.com
Senior Clinical fellow, Vitreoretina, St Thomas' Hospital, Research Fellow, Moorfields & UCL - Cited by 1,104 - Vitreoretinal surgery - Anti-VEGF - Vascular diseases - Uveitis - Artificial Intellig...
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This milestone reflects not just my journey, but the collaborations, mentorship, and ongoing curiosity that drive #academicresearch forward. Thank you to all colleagues, co-authors, and the research community for the continued engagement and support.
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Milestone Achieved: 1,000 #Citations!.🎉🙌🎁🎊🎈🎆🎓. I’m humbled and honoured to share that my work has now been cited over 1,000 times on #GoogleScholar.
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7/7.📝 Sen et al. – “Risk factors and incidence of macular edema in eyes with RVO after cataract surgery”.📅 Published: April 2025.📖 Read: Thank you to my amazing team for bringing this to life!.#MEVOstudy #OphthalmologyResearch.
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6/7.👁️🗨️ Clinical Insight:.Cataract surgery in RVO eyes needs extra care and tailored counseling. Even without pre-op edema, risk of PME lingers, especially with systemic conditions like diabetes. #OphthoTwitter #RetinaTips.
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5/7.📉 Visual Outcomes:.Significant VA improvement overall. But PME, CRVO, or poor baseline VA (<6/12) → poorer final vision.⚠️ CRVO eyes fared worse than BRVO.#VisualAcuity #CRVO.
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4/7.🕒 Timing:.60% of PME occurred within 1 month post-op. 🔎 We recommend routine OCT screening at the first follow-up after cataract surgery in RVO patients. #EarlyDetection #CataractSurgery.
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3/7.💡 Key risk factors:.Diabetes (OR = 2.1). History of CME (OR = 4.62). Anti-VEGF treatment (OR = 4.83).📌 mSICS increased risk in diabetics + hypertensives (OR = 5.86).#RetinalCare #EyeSurgery.
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2/7.📊 Incidence of PME:.Overall: 40.1%. With previous CME: 57.3%. In diabetics: 50%. With CRVO: 48.8%.Even “uneventful” cataract surgeries carry significant risk in RVO eyes. #MacularEdema #Retina.
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🧵 1/7.🚨 Proud to share our latest research published in Indian Journal of Ophthalmology!.Our team led the MEVO study, exploring the risk of Postoperative Macular Edema (PME) in eyes with Retinal Vein Occlusion (RVO) after cataract surgery. Key findings ahead 👇.#MEVOstudy
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Some more reading materials on this topic:. Exciting times ahead!!!😃 😃 😃.
science.org
Retinol binding protein 3 may protect against the progression of diabetic retinopathy by inhibiting glucose uptake into retinal cells.
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🧪 Methodology included:.- #Massspectrometry of vitreous SEVs.- #Immunoblotting and #ELISA validations.- Plasma SEV profiling in patients across DR stages. 📚 Read the full study:
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This is a major step towards developing multi-analyte #biomarker panels for early and accurate #DR screening and paves the way for future therapeutic innovations like RBP3 supplementation.
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Until now, its presence in circulation was hard to detect, limiting its use as a #biomarker. Our findings show that circulatory SEVs can carry retinal biomarkers, opening up non-invasive diagnostic possibilities for vision-threatening diabetic retinopathy.
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Most notably, we discovered a significant reduction of RBP3 levels in patients with proliferative DR (PDR). 💡 Why this matters:.RBP3, a photoreceptor-derived protein, has been known for its protective role in retinal health.
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👩🔬 From the teams at Aravind Medical Research Foundation & Aravind Eye Hospital.In a first-of-its-kind study, we identified Retinol-binding protein 3 (RBP3) in small #extracellularvesicles (SEVs) from both the #vitreoushumor and plasma of patients with #diabeticretinopathy (DR).
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🚨 New Research Alert!. Proud to share our latest work published in #ExperimentalEyeResearch 🚀. 📌 Title: Retinol-binding protein 3 in vitreous and plasma-derived small extracellular vesicles is reduced in proliferative diabetic retinopathy
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