Rexford S. Ahima, MD, PhD
@rex_ahima
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Professor of Medicine, Public Health & Nursing; @hopkinsmedicine;@johnshopkinsSPH; @JHUNursing;@JHU_BDPs; @theNAMedicine; @aaas;@americanacad;@TheEndoSociety
Baltimore, Maryland
Joined December 2016
Physical activity and preclinical Alzheimer disease https://t.co/JF1AhaQMl0
nature.com
Nature Medicine - In cognitively normal older adults at risk for Alzheimer’s dementia, physical inactivity was associated with faster tau protein buildup and cognitive decline.
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Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis: Cell Metabolism
cell.com
The exact mechanisms underlying leptin resistance remain elusive. Here, Wang et al. report that adipocyte-derived EVs and their miRNA cargo are key regulators of central leptin sensitivity and that...
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From microbiome to metabolism: Bridging a two-decade translational gap: Cell Metabolism
cell.com
Despite their initial promise, microbiome-based therapies face translational challenges. This perspective examines the limitations of correlative studies; the mechanistic insights from animal models;...
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JCI - Antiinflammatory actions of glucagon-like peptide-1–based therapies beyond metabolic benefits
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The search for mutations that sperm acquire as men age
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Characterizing circulatory arrest in the human dying process https://t.co/uA71WRw5kN
nature.com
Nature Medicine - The authors conducted prospective multimodal monitoring of simultaneous brain and heart function to define physiological changes during the human dying process leading to...
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Galnt2 neurons in the ventromedial hypothalamus counterregulate hypoglycemia via a brain-liver neurocircuit: Cell Metabolism
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A closed-loop cholesterol shunt controlling experimental dyslipidemia: Cell Metabolism
cell.com
Unal et al. engineered a cholesterol-responsive genetic circuit, which was designed to sense and counteract the elevated levels of cholesterol in circulation. The circuit managed to attenuate a...
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Portal vein-enriched metabolites as intermediate regulators of the gut microbiome in insulin resistance: Cell Metabolism
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Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression: Cell Metabolism
cell.com
Li et al. demonstrate that fatty livers foster a favorable metabolic landscape for breast cancer via adipocyte-oriented exosomes. These exosomes display tropism to mammary adipocytes through the...
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HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer: Cell Metabolism
cell.com
Xiao et al. conducted a systematic investigation into the crucial immuno-metabolic crosstalk within triple-negative breast cancer. They found that HEBP2 promoted FOXA1 nuclear translocation to...
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Another highlight from our July 28 concert at @Jazz_in_Marciac: my Sextet playing "Point/Counterpoint" from The Integrity Suite. Marcus Roberts, piano; Reginald Veal, bass; Jason Marsalis, drums; Chris Lewis, sax; Abdias Armenteros, sax
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Portal vein-enriched metabolites as intermediate regulators of the gut microbiome in insulin resistance: Cell Metabolism
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Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction | New England Journal of Medicine
nejm.org
Current guideline recommendations for the use of beta-blockers after myocardial infarction without reduced ejection fraction are based on trials conducted before routine reperfusion, invasive care,...
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Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism: Cell Metabolism
cell.com
Noncanonical clock regulators bridge genetics and nutrition to mediate 3D enhancer-promoter interactions, contributing to diurnal rhythm variation and metabolic disease risk.
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Effect of ultra-processed food consumption on male reproductive and metabolic health: Cell Metabolism
cell.com
This randomized controlled nutrition intervention conducted in males of reproductive age shows that, compared with an unprocessed diet, consumption of ultra-processed foods impairs metabolic and...
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