Riccardo Calvani
@r_calv
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Researcher on Gerontology and Geriatrics @Unicatt
Roma, Lazio
Joined June 2015
potential dual role of tau phosphorylation: plasma phosphorylated-tau217 in newborns and Alzheimer’s disease | Brain Communications | Oxford Academic
academic.oup.com
Gonzalez-Ortiz et al. report measurements of plasma phosphorylated-tau217 across different age groups. Levels were significantly higher in newborns than in
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Geroscience: A Translational Review | Nutrition, Obesity, Exercise | JAMA | JAMA Network
jamanetwork.com
This review explores the discipline of geroscience, which aims to define and modify aging-related biologic pathways, slow age-related disability, prevent age-related diseases, and increase disabili...
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Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy: Cell
cell.com
Advances in mapping how the brain regulates energy homeostasis, together with progress in peptide-based pharmacotherapy, highlight emerging opportunities for obesity treatment with the potential to...
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Convergence and divergence of individual immune responses over the life course | Science
science.org
Three ingredients create the strikingly variable immune trajectories observed across human populations: (i) genetic variation, (ii) individual-scale generation of additional genetic diversity solely...
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Immune system influence on physiology | Science
science.org
The immune system’s central function is to maintain homeostasis by guarding the organism against dangerous external and internal stressors. Immunity’s operational toolbox contains diverse processes,...
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Stressomic: A wearable microfluidic biosensor for dynamic profiling of multiple stress hormones in sweat | Science Advances
science.org
A wearable sensor enables dynamic and noninvasive monitoring of multiple stress hormones to personalize stress management.
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🏥➡️💪 1 in 3 older adults lose independence after hospital discharge. But exercise might be the key to recovery. Hot off @LancetLongevity press: A meta-analysis with BIG implications. 📋 https://t.co/oEos7WGAQC
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Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial | Dementia and Cognitive Impairment | JAMA | JAMA Network
jamanetwork.com
This randomized clinical trial assesses the effect of structured vs self-guided multidomain lifestyle interventions on changes in global cognitive function over 2 years among older adults at risk of...
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Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis - The Lancet Public Health
thelancet.com
Although 10 000 steps per day can still be a viable target for those who are more active, 7000 steps per day is associated with clinically meaningful improvements in health outcomes and might be a...
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🧵1/ 🚨 New study alert! In our latest work, just published in Nature Aging, we show that what older adults eat can shape how fast they accumulate chronic diseases over time: Here’s what we found 👇
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Global Neurodegeneration Proteomics Consortium
nature.com
The Global Neurodegeneration Proteomics Consortium is a multi-national database that aims to leverage proteomics and clinical data to understand and improve ...
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The exposome of healthy and accelerated aging across 40 countries | Nature Medicine
nature.com
Nature Medicine - Analyses of the exposomes of populations across 40 countries found global disparities in healthy aging attributed to diverse biological, socioeconomic and political factors, with...
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Physical activity trajectories and accumulation over adulthood and their associations with all-cause and cause-specific mortality: a systematic review and meta-analysis | British Journal of Sports Medicine
bjsm.bmj.com
Objective To understand the associations of trajectories and accumulation of physical activity (PA) over adulthood with all-cause, cardiovascular disease (CVD), and cancer mortality. Design Systema...
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Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study - The Lancet Neurology
thelancet.com
Baseline and longitudinal plasma p-tau217 were associated with subsequent decline in global cognition, progression to dementia, and increased tau burden, whereas baseline p-tau217 and GFAP were...
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Neuroinflammation across neurological diseases | Science
science.org
The brain’s response to injury includes the activation of intrinsic microglia and the influx of leukocytes, collectively constituting neuroinflammation, the “flame” of the brain. Although details...
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How your brain controls ageing — and why zombie cells could be key
nature.com
Nature - Research is revealing the cellular mechanisms that link mental well-being and longevity.
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Structured Exercise after Adjuvant Chemotherapy for Colon Cancer | New England Journal of Medicine
nejm.org
Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking. In this phase 3, randomized trial conducted at 55 centers, ...
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Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1 | Nature
nature.com
Nature - ADP-heptose binds to ALPK1, triggering transcriptional reprogramming and NF-κB activation, endowing pre-leukaemic cells with a competitive advantage due to excessive clonal...
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Cells are swapping their mitochondria. What does this mean for our health?
nature.com
Nature - Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.
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Integrating the environmental and genetic architectures of aging and mortality | Nature Medicine
nature.com
Nature Medicine - Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for...
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