
Pooja Prasad, MD
@poojaprasad91
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@UCSF AHFTC fellow, a sailor in my dreams @cardionerds #FIT #WIC @wellesleyalums @URochester_SMD @UCD_IM @OHSUCardFellows
Portland, Oregon
Joined December 2011
🔬 Mentorship Pairing #2, sponsored by @BridgeBioPharma, winners announced! Congratulations to @poojaprasad91 & @HannaGaggin who will delve into critical aspects of ATTR-CM research through their collaborative project over the next 12 months. #WomenAsOneAwards #WIC
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🍼 405. @CardioNerds Case Report: Like Mother, Like Son 💗Explore a case of peripartum cardiomyopathy & infantile HCM unifying a diagnosis💗 Feat: Drs. @achdoctmoe @HarrisonJVDMD, Sri Nayak & Donny Mattia, @poojaprasad91 ‼️ @MayoAZCVFellows Link below👇👇👇
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@mitralarcade (@UTSWMedCenter) presents on 41W w/ deafness who underwent HM3 w/ use of haptic devices (bed shaker, pager, smartwatch) to ensure detection of LVAD alarms. Kathleen Grady (@NorthwesternMed) emphasizes need to optimize access, safety, personalization in LVAD
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Great session on early career and trainee clinical case dilemmas, loved the pairing of trainee clinical case + expert discussant. A little bit of everything 🫀🫁 ⚙️ #HeartTransplant #LungTransplant #MCS #LVAD #PVD #PAH
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@SebHascoet (@HMLannelongue) PRO for transcutaneous shunts,🎈septostomy outcomes improving, ⬇️RAP, ⬆️CI, helps symptoms, patency better w/ atrial flow regulators. Re: Potts TC options game-changing, easy when PDA present, still feasible w/o PDA & new devices in development
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David Morales (@CincyChildrens) CON for transcutaneous shunts. Data for atrial septostomy old and limited in kids. Surgical Potts pts come off IV prostanoids, better outcomes than lung txplt. Registries of TC-Potts a/w worse outcomes, complicates/limits eventual txplt
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@3rdheartsound notes biomarkers in CAV not currently guideline-recommended, but several metabolic (TChol, TGs), inflammatory (CRP), proteomic, circulating microRNAs, immunologic (Class II DSAs, GEP), injury markers (BNP, troponin, ddcfDNA) all have been associated with CAV
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Lindsey Aurora outlines txt and prevention: aspirin (RCT AERIAL TBD), early PSI/mTOR, LDL control (aim <100 or <50 if CAV present). PCSK9i safe & effective post-OHT. Redo OHT for grade 3 more advantageous if LV dysfunction present. In the future: Belatecept? tocilizumab? SGLT2i?
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Guillaume Coutance discusses that the natural history of CAV has 4 major trajectories (none, mild/late, severe/late, and severe/early). Invasive biomarkers and predictive models will one day help us define patients’ trajectories
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Tor Clemmensen takes us through CAV pathogenesis: Step 1 endothelial injury and dysfunction (relating to donor, recipient, and surgical factors); Step 2 smooth muscle cell proliferation (CMV infection, DSAs).. much yet to be known
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Kicking off the PH content @ISHLT with an in depth session on Coming together: improving survival in PAH! #ISHLT2024
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@SophiaAirhartMD discusses risk assessment in adults with PAH: achieving low risk status ASAP is key to improved 1 year survival, utilization of risk assessment remains low.
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Allen Everett reviews the development and implementation of a risk assessment model in pediatric PAH patients in PPHNet, with validation against Dutch and Spanish registries.
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@IsaOpitz on f/u. Persistent PH after PEA common (25%), PVR>5 a/w worse survival. Re-assess at 3-6 mo, RHC needed. Target FC I-II & normalize resting hemodynamics. Need for standardized f/u schemes. Echo/ NTproBNP (>300) at 6mo may help (some missed cases), early data on microRNA
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Marc de Perrot on interventions. PEA for segmental dz, but BPA+meds beneficial. RACE & MR BPA RCTs (BPA vs rio in non-surgical)– BPA w/ better hemodynamics but adverse events. PEA risk driven by RV failure, VA-ECMO to bridge to recovery after PEA beneficial
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Rise and shine! ☀️ Early birds at #ISHLT2024 caught the worm with a groundbreaking session on CTEPH. #PVD #CTEPH #SunriseScience
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In a post-hoc analysis of STELLAR and PULSAR, @mardigomberg stratified pts by cardiac index (cutoff of 2 or 2.5) & sotatercept improved 6MWD, PVR, NTproBNP, echo parameters (RVEF, TAPSE/SPAP), WHO-FC in all CI subgroups. Similar safety across CIs
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@RaymondBenzaMD's analysis of TORREY compared risk tools (REVEAL 2.0 & Lite 2, COMPERA 2.0, Non-invasive French), showed seralutinib favorably shifted risk scores at 24 wks. COMPERA 2.0 significantly improved (OR 9.32, p<0.05), REVEAL 2.0 and French w/ trend
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🚀 Dive into the primary data with 'What’s New in Pulmonary Vascular Disease' - the latest updates from registries and clinical trials moderated by @MarcSimonMD @mardigomberg #ISHLT2024 #PAH #PVD
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