Phil Jean-Richard-dit-Bressel
@philJRDB
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Behavioural neuroscientist / Experimental psychologist @ UNSW Sydney
Sydney, New South Wales
Joined November 2019
If you missed it - this finally got published (with some cool new Supplementary data!)
spiedigitallibrary.org
SignificanceFiber photometry is a powerful tool for neuroscience. However, measured biosensor signals are contaminated by various artifacts (photobleaching and movement-related noise) that undermine...
I don't usually broadcast preprints, but thinking this should be exception (in case it helps now) https://t.co/MfzoSZ4OUY Isosbestic signals are used to artifact-correct experimental signals in fibre photometry, often by OLS regression. Inherent problems with this approach. 1/
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I'm glad my last interactions with her were good ones. If there's any takeaway from this, its to never forget to tell those you love how much they mean to you.
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I too had a complicated relationship with her, even from childhood. I studied psych in part to better understand and maybe help her. I dont think that goal was ever achieved. I wish I'd had more time.
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Mum was also a reason I chose to study psychology. She was a larger than life character, but there were problematic sides to her that, amongst other things, would implode her relationships with family, friends, co-workers. She suffered a lot from this, even till the end..
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Mum was a self-made business woman, working day & night 6+ days/wk to put me & my bros through high school and undergrad - opportunities she never got herself. $ ran out before we all finished, but she got us far enough along that we could support ourselves and each other.
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I don't usually post personal stuff here, but my mum passed away last week and I wanted to share a little about how she's the reason I do what I do.
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New pub: We saw greater punishment resistance for cocaine with RI60 schedule vs RR20. With food, similar results in ♀️ but ♂️ resistant with RR20 and RI60. @AdelisCruz_PhD @morg_palz @SophiaN_Handel Special issue on Punishment in NLM edited by @philJRDB
https://t.co/CY5f8v5IpA
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https://t.co/eOND4sIxWZ Apply here, closes 5 Feb ☝️ We are looking for someone who has experience conducting and analysing in vivo neural recordings, preferably fibre photometry. Rat social behaviour/conditioning experience will be advantageous. Interest in drug dev ideal!
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Ready to TRAVEL to Panama? Apply for an IBNS TRAVEL Award Today! https://t.co/QjJHl9YyCh
#IBNS2024 #IBNSConnect
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Lots more worth mentioning. Happy to chat about it🤓
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Fibre photom analysis is still the wild west, but we're thinking IRLS, LP filter, and dFF calculation could serve as sensible shared process across analysis pipelines (until something even better comes along) MATLAB code for getting dFF via IRLS: https://t.co/sDZV10tbNp 5/
github.com
Data and scripts used for analyses of OLS vs robust regression on real and simulated photometry data - GitHub - philjrdb/RegressionSim: Data and scripts used for analyses of OLS vs robust regressi...
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In terms of "true signal" extraction (based on simulations): IRLS >OLS low-pass filter > no filter dFF calculation > dF calculation We think this holds true across photometry data and sensible analysis parameters. 4/
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We made some scripts to simulate fibre photometry recordings (feel free to use https://t.co/sDZV10tbNp) 3/
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We reckon solution to these OLS issues is instead fitting isosbestic to experimental signal using iteratively-reweighted least squares (IRLS) regression. In theory this focuses fitting of isosbestic signal onto the artifactual component of experiment signal (as intended). 2/
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I don't usually broadcast preprints, but thinking this should be exception (in case it helps now) https://t.co/MfzoSZ4OUY Isosbestic signals are used to artifact-correct experimental signals in fibre photometry, often by OLS regression. Inherent problems with this approach. 1/
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