Owen Jensen
@Owen_D_Jensen
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Postdoctoral Fellow University of Colorado Anshcutz Medical Campus
Joined February 2018
First review article from my lab! Very proud of this effort by @Owen_D_Jensen and the rest of the Ost lab team. Controlling Candida: immune regulation of commensal fungi in the gut | Infection and Immunity
journals.asm.org
The human intestinal microbiome, a complex ecosystem of microorganisms residing in the gastrointestinal tract, plays a pivotal role in regulating numerous aspects of human physiology, development,...
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Just published: Use of a MAIT-Activating Ligand, 5-OP-RU, as a Mucosal Adjuvant in a Murine Model of Vibrio cholerae O1 Vaccination https://t.co/HAAIoiHoUj
@Owen_D_Jensen @GlobalGutHealth
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How often do international travelers get #diarrhea? We report @AJTMH, that 23% of Utah-based travelers had diarrhea (1.1 episodes per 100 travel-days), and identified several risk factors. Work led by @uofuour Valerie Fernandez & @EpiPoopologist. @_ISTM_
https://t.co/rxRR7SqUZG
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Though it feels like we opened up more questions than we answered, we hope this study highlights MAIT cells as an interesting potential target for adjuvants to improve mucosal vaccines! 8/n
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Most exciting to us, using ELISA we show that MAIT adoptive transfer rescues V. cholerae-specific IgA responses to WT B6 levels 7/n
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Using flow on digested lung tissue at D42 post initial challenge, we show that adoptively transferred MAITs persist >8 weeks post transfer and that MAIT transfer drives plasmablast differentiation 6/n
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2nd half of paper we utilize a live V. cholerae intranasal vaccination model in TCRaKO mice w/ w/o adoptive transfer of MAIT cells to show the sufficiency of MAIT cells to aid in B cell help at the mucosa 5/n
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Interestingly, using IHC on tonsil cryosections, we show that PD1+ MAITfh cells frequently localized in or around germinal centers compared to PD1- MAIT cells suggesting a Tfh-like function in GCs 4/n
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Using flow, ELISA, and qPCR MAITfh cells had increased expression of key B cell help cytokine, IL-21, compared to CXCR5- MAIT cells 3/n
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In collaboration with @globalguthealth, @shubhanshitriv1, @LabFairfax, Scott Hale, and Jeremy Meier, we describe a population of CXCR5+ MAIT cells enriched in human tonsils that highly express Tfh co-stimulatory molecules ICOS and PD1 2/n
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Very excited to share my 1st first author paper accepted in @SciImmunology where we studied a novel population of Tfh-like MAIT (MAITfh) cells in humans and show the ability of MAIT cells to aid in B cell help in the mucosa
science.org
We identify a MAIT cell subset expressing T follicular helper markers and show the ability of MAIT cells to support B cell responses in the mucosa.
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New research from @UofUMedicine identifies a special set of #MAIT mucosal T cells found in tonsil tissue that support B cells in fighting bacterial infection. https://t.co/c0eruSAgj4
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Our work out @eLife, showing in exp models & patient samples that #MAIT cells mediate protective host responses in #sepsis. Work led by @shubhanshitriv1 collab w/@RondinaLab @racampbell04 @EAMiddleton5 @MulveyLab @Owen_D_Jensen @Claudia_BioUT. @UofU3i
https://t.co/ehcpx2SiOl
elifesciences.org
Mucosal-associated invariant T (MAIT) cells, highly activated and dysfunctional in sepsis patients, contribute to tissue-specific cytokine responses that are protective against mortality during...
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Our latest preprint: Why is diarrhea assoc w/⬆️ risk of subsequent pneumonia? We report #inmice that gut infection alters lung immune cells, and ⬆️ susceptibility to pneumonia, implicating neutrophils, NETs. Work led by @shubhanshitriv1
biorxiv.org
Pneumonia and diarrhea are among the leading causes of death worldwide, and epidemiological studies have demonstrated that diarrhea is associated with an increased risk of subsequent pneumonia. Our...
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Scientists: Support for the innovation engine of American science: immigrants - Sign the Petition! https://t.co/URNjadMNR4 via @Change
change.org
Support for the innovation engine of American science: immigrants
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Now out: Our article in @SciImmunology on uses for SARS-CoV-2 serology. @JulietBryantBr1 @andrewazman @TheFerrariLab @ben83638 @maciekboni @KylaHayford @michaelmina_lab @isabelrodbar @yapboum2. https://t.co/mgtit2rTh1 Key points:
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New paper out: We, with Tai Diep and others at Institut Pasteur HCMC, showed feasibility of using dried blood spots for #cholera serosurveillance, in a post-elimination setting. One small step in path to #EndCholera. @UofU3i @UofUHealth @andrewazman
https://t.co/Wmr93WyQtY
academic.oup.com
Abstract. Cholera remains a significant public health problem worldwide. In settings of declining incidence, serosurveillance may be used to augment clinic
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Today #AAI sent a letter urging the President & Congressional Leaders to heed the advice of Dr. Fauci & other experts during the #COVID19 pandemic. Read the letter: https://t.co/rRuNQc8XBs
@NIAIDNews @NBCNews @ABC @CBSNews @FoxNews @CNN @nytimes @washingtonpost @USATODAY @NIH
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