Nicolas Parisot (nicolasparisot.bsky.social)
@niparisot
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PhD in Bioinformatics currently working on insect symbiosis at @INRAE_UMR_BF2i
Lyon, France
Joined July 2015
RT @INRAE_DPT_SPE: Des chercheurs du laboratoire Biologie Fonctionnelle, Insectes et Interactions (BF2i) @INRAE_France et @insadelyon déchi….
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RT @INRAE_Lyon_Gre: 📰 Recherche . Une équipe du laboratoire @INRAE_UMR_BF2I (@INRAE_France , @insadelyon) , en collaboration avec l'@IGFLyo….
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Congrats @MGFerrarini and co-authors! This master piece on the molecular dialogue between the cereal #weevil and its #endosymbiont has now been published in @MicrobiomeJ .
It's finally out !! Our enormous work on the coordinated responses of host and its intracellular bacteria throughout the life cycle of the cereal weevil is available on @bioRxiv ! 🧶 A great collaboration @INRAE_UMR_BF2I @IGFLyon @LbbeLyon @MAP_UMR5240 1/6.
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📣 Check out this huge piece of work done by @MGFerrarini 💪 Dual RNA-seq of #weevil and its #endosymbiont through 1️⃣2️⃣ stages of insect development!.
It's finally out !! Our enormous work on the coordinated responses of host and its intracellular bacteria throughout the life cycle of the cereal weevil is available on @bioRxiv ! 🧶 A great collaboration @INRAE_UMR_BF2I @IGFLyon @LbbeLyon @MAP_UMR5240 1/6.
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RT @insadelyon: 📅 𝗦𝗔𝗩𝗘 𝗧𝗛𝗘 𝗗𝗔𝗧𝗘 : 𝗗𝘂 𝟯 𝗮𝘂 𝟳 𝗮𝘃𝗿𝗶𝗹 𝟮𝟬𝟮𝟯, l'INSA Lyon vous donne rendez-vous pour la 1re édition de sa semaine du numérique r….
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RT @INRAE_UMR_BF2I: 🧪🧬 Come join us in beautiful Lyon! We are looking for 3 students to apply to the E2M2 doctoral fellowship. It's all abo….
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Finally, I thank @rita_rebollo @clementgoubert and @TreepVieira for the time spent to analyze this genome full of repeats. You, guys, can be proud of what you have done here! 13/13.
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A big thanks also to @VargasChavezC for his incredible contribution, so challenging given the complexity of the genome. 12/n.
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I would like to end this thread by thanking A. Heddi and @amparo_latorre for integrating me in the middle of their journey and for their strong support. 11/n.
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On #epigenetics @rita_rebollo, A. Vallier, @GautierRichard, @VargasChavezC & co found only DNMT1 & 2 (not 3) and around 1% of #CpG methylation. They also annotated the #piRNA genes, and albeit the presence of SIWI, most piRNA-related genes are overexpressed in germ vs soma 10/n.
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The Imd pathway is not only present but it is also functional and has evolved molecular features necessary for endosymbiont control and host immune homeostasis. As seen in and 9/n.
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They found that despite the interaction with S. pierantonius, the rice #weevil genome encodes the canonical genes involved in the 3 main #antimicrobial pathways Toll, Imd, and JAK-STAT. 8/n
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The analysis of #immunity related genes was done at @INRAE_UMR_BF2I. @cmonegat and @AnnaZaidmanRemy coordinated the work of our former #PhD students @VargasChavezC @Justin_Maire @flmasson and A. Vigneron. 7/n.
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And thanks to the help of our collaborators we had the opportunity to annotate developmental genes (@CallaertsLab from @KU_Leuven) and odorant receptors (@EmmaJoly8, N. Montagné et @CamilleBurgh from @iEESParis) 6/n.
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@VargasChavezC and I annotated lots of gene families including digestive enzymes, cuticle proteins, detoxification and #insecticide resistance related genes. 5/n.
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But both host and symbiont collaborate to synthesize some essential vitamins! 4/n
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With the invaluable help of the SymT group from @INRAE_UMR_BF2I we have also reconstructed the #metabolic pathways from both #symbiotic partners. Specific losses of enzymes in the #weevil genome are limited while its #endosymbiont has suffered much more degradation. 3/n.
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@VargasChavezC and @gabaldonlab performed a comprehensive #phylogenomic analysis of the rice #weevil and found that this insect has a high gene expansion rate when compared to other beetles. 2/n
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Picking up where @rita_rebollo left, we spent a couple of years annotating and analyzing the rest of the rice #weevil #genome (ok, the 15% left after removing repeats)! All info presented here is on the huge Additional file 2 in @bmcbiology 1/n.
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RT @rita_rebollo: ⭐️ It is with immense pleasure that we share with you the published #Sitophilus oryzae #genome paper in @bmcbiology http….
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