Saul Kato
@neurotheory
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I study things that think. UCSF neuroscience professor, Foundations of Cognition Lab. Moved here: https://t.co/1S9bwkHcxc
San Francisco, CA
Joined June 2015
Cross-post from our new acct at We're happy to share our preprint on tardigrades as a new model organism for neuroscience. Exciting times for these little critters!
focolab.org
We have been making the case for some time that tardigrades, aka water bears, would be an amazing new model organism for certain big systems neuroscience questions. We put this into a detailed paper...
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Not at the Supreme Court yet, but the wheels are in motion. More suits will follow.
nytimes.com
Millions of articles from The New York Times were used to train chatbots that now compete with it, the lawsuit said.
Prediction: a copyright violation case against generative AI companies will go before the Supreme Court by end of year. Result: large gen AIs will need to be retrained on only demonstrably rights-cleared content. Gen AI will be ruled to not fall under fair use.
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RT @neurotheory: Prediction: a copyright violation case against generative AI companies will go before the Supreme Court by end of year. Re….
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Roche / Genentech has acquired Herophilus's scaled human brain organoid + automation + ML drug discovery platform, seven years in the making. This is a huge milestone for our interdisciplinary team and for this modern approach to therapeutics research.
businesswire.com
Herophilus, a leading biotechnology company with the mission to discover neurotherapeutics to cure complex brain diseases, today announced that Genentech, a ...
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Prediction: a copyright violation case against generative AI companies will go before the Supreme Court by end of year. Result: large gen AIs will need to be retrained on only demonstrably rights-cleared content. Gen AI will be ruled to not fall under fair use.
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Geoff Hinton leaving Google is a serious data point that we have surprised ourselves at the "elbow" in apparent AI progress.
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Happy to share a small study from Herophilus comparing transduction of neurons and astrocytes in human cortical organoids by off-the-shelf AAVs for gene therapy. AAV6 transduced neurons better than AAV2 and AAV9, surprisingly.
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The Rett Syndrome Research Trust is funding Herophilus' in vivo studies of HRP-12975, a small molecule x-chromosome reactivator discovered using our human organoid-based neuroscience discovery platform. #organoids #rettsyndrome #drugdiscovery
businesswire.com
Herophilus announced today that in vivo studies underway of its lead candidate HRP-12975 are funded in part by the Rett Syndrome Research Trust (RSRT). HRP-1...
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Happy to announce the results from the @Herophilus_sf research collaboration with @CerevelTx in a preprint: "Neuroimmune Cortical Organoids Overexpressing C4A Exhibit Multiple Schizophrenia Endophenotypes"
biorxiv.org
Elevated expression of the complement component 4A (C4A) protein has been linked to an increased risk of schizophrenia (SCZ). However, there are few human models available to study the mechanisms by...
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I wrote this piece on the necessity of real-world biology experiments in drug discovery, even for AI/data-driven strategies. @Herophilus_SF #organoids.
saulkato.medium.com
Every data/AI-driven drug discovery company must eventually do real-world biology experiments. A new class of human in vitro experimental…
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Follow the microglia as they surveil the neural tissue in a neuroimmune cerebral organoid (NICO) and keep it healthy. Microglial motility is just one key readout of neuroimmune function.
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RT @michaelmina_lab: Holy cow. Despite all the evidence, @CDCgov is still promoting an exceptionally dangerous practice of leaving isolat….
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Challenge trials, even small n, allow a degree of controlled and precise measurements you can't get from field trials.
nature.com
Nature Medicine - In the first SARS-CoV-2 challenge study in humans, 36 young, healthy adult participants were intranasally inoculated with virus and monitored for productive infection, symptoms,...
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Need to analyze your ML embeddings for bias in complex real world datasets? This is an important practice to follow when using ML for science. See how we do it at Herophilus in this paper in Cell Patterns, Cell's new ML journal.
cell.com
Machine learning (ML) models may be biased by hierarchically organized confounding variables, which are frequently present in complex datasets. We present a statistical method, the rank-to-group...
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gonna go buy myself some bio-fuel (lunch) with these fungible tokens in my real-wallet.
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