Narayanan Lab
@narayananlab
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@narayananlab.bsky.social
Iowa City, IA
Joined April 2010
Excited for this webinar on Computational Properties of the Prefrontal Cortex from the Journal of Neuroscience: https://t.co/h3Cw3xMDOd
@SfNtweets
neuronline.sfn.org
“Ultimately, the investigation of prefrontal cortex function is fundamentally an effort to understand prefrontal computations” (Narayanan, et al. 2025).
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Our latest paper showing that a few minutes of EEG can predict mortality in PD is now up:
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Congrats to Alexandra Bova on winning a BBRF Young Investigator Award!
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Our issue on Computational Properties of the Prefrontal Cortex is now: https://t.co/qR16KjAn9p These articles capture some of the incandescence of the CPPC conferences... https://t.co/tvDcufmoUK
https://t.co/9GDs9g9Oby
https://t.co/bjRhYlXuzN Next one in Toronto in ~2026!
cppc.web.ox.ac.uk
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D1FLP mice are now available from JAX! https://t.co/s8Xpp5IYiH Detailed in this paper: https://t.co/ARijQS3chO Let us know if they work for you...
pubmed.ncbi.nlm.nih.gov
We demonstrated brain-wide GFP expression driven by Drd1-Flpo, suggesting that this mouse line may be useful for comprehensive anatomical and functional studies in many brain regions. The Drd1-Flpo...
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Our latest paper predicting PD mortality from ~2 minutes of resting-state EEG :
medrxiv.org
Background Parkinson’s disease (PD) increases mortality is difficult to predict because of its heterogeneity and the availability of very few reliable which prognostic markers. Objectives We used...
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Credits go to my world-class team. I am especially grateful to my mentors who inspired and supported/funded my academic curiosity. Our goal remains: to bridge the gap to human studies and better understand the link between neurophysiology and subjective experience ❤️
Excited to share our latest paper in @TheJournal_Pain, led by my dear friend @oliverflouty (@USouthFlorida)! https://t.co/RmsmQsVdce Using #ECoG in 4 sheep, we explored supraspinal effects of high-frequency #spinalcordstimulation—revealing region- and frequency-specific
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Our latest work: https://t.co/u4HxySqVaS We show that corticostriatal ramping activity can't readily be explained by movements using motion tracking, and that ramping can't readily be explained by reward anticipation in mice performing timing and Pavlovian tasks.
biorxiv.org
Across species, prefrontal and striatal neurons exhibit time-dependent ramping activity, defined as a consistent monotonic change in firing rate across temporal intervals. However, it is unclear if...
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another new preprint from our group on predicting cognitive changes in PD from resting state fMRI: https://t.co/f5izHEFmJh Led by @BrookeYeagerMS!
medrxiv.org
Cognitive symptoms are common in Parkinson’s disease (PD), yet the underlying brain mechanisms remain poorly understood. To address this gap, we investigated the relationship between functional...
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And we know the temporal code in prefrontal cortex – it’s ramping activity. Surprisingly, ramps didn’t change in slope, but became more variable! Lots more details in the paper. This paper challenged our fundamental view of what we think amphetamine does…
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Amphetamine has been thought to reliably affect timing accuracy. We find in a meta-analysis and in our data that it actually more reliably affects precision:
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Our work showing that amphetamine affects behavior by degrading prefrontal temporal variability is now out at Neuropharmacology: https://t.co/y7Scy4Dnd0 Work by Matthew Weber @MatthewWeberPhD As always, data and code at: https://t.co/Rq4rZMHXkq
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New preprint from our group showing that drugs that enhance glycolysis slow neurodegeneration in Alzheimer's disease - data from yeast to humans: https://t.co/jo1wSdGe5Y Data and Code: https://t.co/AQBGgUAIQ6
https://t.co/710wdXRMiH
narayanan.lab.uiowa.edu
Please send any questions about data to [email protected]
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Our latest work is up as a version of record on eLife: https://t.co/rso7p89Joz Thread at Bluesky: https://t.co/gBmpQClW2H As always, data and code are available at
narayanan.lab.uiowa.edu
Please send any questions about data to [email protected]
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Our newest paper is up on pubmed: https://t.co/ARijQS3chO We've generated a new mouse that enables manipulating of neurons expressing the D1 dopamine receptor - D1-FLP mice
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Very proud what our nascent Center for Neurodegeneration has done here in Iowa:
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