Narayanan Lab
@narayananlab
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@narayananlab.bsky.social
Iowa City, IA
Joined April 2010
Our latest paper predicting PD mortality from ~2 minutes of resting-state EEG :
medrxiv.org
Background Parkinson’s disease (PD) increases mortality is difficult to predict because of its heterogeneity and the availability of very few reliable which prognostic markers. Objectives We used...
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RT @oliverflouty: Credits go to my world-class team. I am especially grateful to my mentors who inspired and supported/funded my academic c….
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Our latest work: We show that corticostriatal ramping activity can't readily be explained by movements using motion tracking, and that ramping can't readily be explained by reward anticipation in mice performing timing and Pavlovian tasks.
biorxiv.org
Across species, prefrontal and striatal neurons exhibit time-dependent ramping activity, defined as a consistent monotonic change in firing rate across temporal intervals. However, it is unclear if...
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another new preprint from our group on predicting cognitive changes in PD from resting state fMRI: Led by @BrookeYeagerMS!.
medrxiv.org
Cognitive symptoms are common in Parkinson’s disease (PD), yet the underlying brain mechanisms remain poorly understood. To address this gap, we investigated the relationship between functional...
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And we know the temporal code in prefrontal cortex – it’s ramping activity. Surprisingly, ramps didn’t change in slope, but became more variable!. Lots more details in the paper. This paper challenged our fundamental view of what we think amphetamine does…
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Amphetamine has been thought to reliably affect timing accuracy. We find in a meta-analysis and in our data that it actually more reliably affects precision:
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Our work showing that amphetamine affects behavior by degrading prefrontal temporal variability is now out at Neuropharmacology: Work by Matthew Weber @MatthewWeberPhD . As always, data and code at:
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New preprint from our group showing that drugs that enhance glycolysis slow neurodegeneration in Alzheimer's disease - data from yeast to humans: Data and Code:
narayanan.lab.uiowa.edu
Please send any questions about data to [email protected]
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Our latest work is up as a version of record on eLife: Thread at Bluesky: As always, data and code are available at
narayanan.lab.uiowa.edu
Please send any questions about data to [email protected]
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Our newest paper is up on pubmed:. We've generated a new mouse that enables manipulating of neurons expressing the D1 dopamine receptor - D1-FLP mice
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Very proud what our nascent Center for Neurodegeneration has done here in Iowa:
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RT @sokol_mdphd: The time has finally arrived! Check out this amazing thread by @theILCguy and our manuscript that is finally live for all….
nature.com
Nature - A γδ T cell–IL-3 signalling axis is defined that controls the allergen responsiveness of cutaneous sensory neurons, leading to evidence for an immune rheostat that governs...
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RT @BillDauerNeuro: Congrats to all - esp @suminkim28 - for years of hard work and partnership to advance understanding of DYT1 dystonia, T….
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Nice article by @HannahThomasy in @TheScientistLLC about the complexities and dangers of the dopamine detox: As a Parkinson's neurologist and researcher, I hope we can move past this bad idea. With @asbova9's pic of nigra dopamine neurons.
the-scientist.com
The fad of temporarily fasting from pleasurable activities likely won’t “reset” dopamine levels and doesn’t accurately reflect this molecule’s nuanced functions.
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And @SivakumarKartik has already left us after undergraduate and post-bac research with us to start his MSTP program @WestVirginiaU . Kartik was profiled in the @NewYorker: .
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We'll miss Alexis Oppman, an oustanding post-bac research assistant who will go on to Dental School at UIowa, supported by the US Navy.
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Congrats to Julia Kryca, an Iowa undergraduate and now a post-bacc who will start medical school at Poznan University of Medical Sciences this fall
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