
Mary Lou Jepsen, PhD
@mljmljmlj
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Chairman & Founder Openwater, Former exec @Goog & FB, Co-founder & CTO One Laptop per Child MIT Prof., PhD Physics Brown U, Deeply technical w/ ~300 patents
San Francisco, CA
Joined May 2009
Yesterday on stage at Wired Health in Boston, I did something I’ve never done before: I used a radical new medical device live on myself—while speaking. No hospital. No implants. No hole drilled in my skull. Just a lightweight headset, registered to my head using nothing more
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10/ Our mission is simple to state, hard to achieve: 1/ A universal device to treat many diseases. 2/ A path to deliver it quickly and affordably to everyone. Healthcare is too expensive. It’s too slow. And it’s too often anti-innovation. By making the tools open, shared,
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9/ As trials scale, so does the data. We envision decentralized clinical trials on the blockchain, where patients can choose whether to share their data, retract it, or even receive micropayments for contributing. If you become the next Henrietta Lacks, you or your family could
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8/ Oh, and we also made a diagnostic device. Our holographic infrared blood-flow system measures blood flow, by some measures with twenty times the accuracy of multi-million-dollar MRI machines, in a portable unit. We’ve already demonstrated LVO stroke detection with excellent
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7/ Through our partners worldwide—eager to access these systems at a fraction of traditional cost—hundreds of trials are now poised to run in parallel across a dizzying array of diseases, generating safety and efficacy data at unprecedented scale with the promise of rapid and low
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6/ After years of building room-sized prototypes, we compressed a phone-booth-sized laser onto a single chip. We collapsed entire carts of analog electronics into miniaturized PCBs. And we designed slim, easy-to-register ultrasound systems using novel semiconductor–ultrasonic
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5/ Why does this matter? Because healthcare is broken. A single new medical device typically runs $650 million in capitalized costs and takes 13 years to get through regulatory approval. That’s one disease, one device, one at a time. It’s too slow, too expensive—and meanwhile,
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4/ In brain organoids seeded with glioblastoma, one of the deadliest cancers, our treatment outperformed chemotherapy. In mice, it shrank tumors dramatically. Human trials are next. We’re even exploring stimulation of stem cells, rejuvenation of aging cells, and deactivation of
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3/ In a clinical trial with patients suffering severe, treatment-resistant depression, two hours of therapy with this device has put a large percentage into lasting remission—without drugs. By tuning the frequency differently, we’ve destroyed cancer cells without harming nearby
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2/ The device uses focused ultrasound—but not the expensive, room-sized machines that burn holes in deep tissue to destroy tumors. Ours is small, low-intensity, and radically affordable. It uses sound intensities lower than those used on pregnant women and their fetuses for
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1/ Yesterday on stage at Wired Health in Boston, I did something I’ve never done before: I used a radical new medical device live on myself—while speaking. No hospital. No implants. No hole drilled in my skull. Just a lightweight headset, registered to my head using nothing more
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What a line up. About to go on stage with this excellent company at Wired Health Boston. https://t.co/EYz8drsO2i
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Our partner, @Kitware has a nice post about our collaboration on the Open-LIFU platform. #slicer #kitware #openwater #LIFU
kitware.com
We are excited to showcase a collaboration between Openwater and Kitware Inc. to accelerate the development and adoption of Low-Intensity Focused Ultrasound (LIFU) technology. Combining Openwater’s...
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A new clinical trial starts using our Open-Motion system in a new way: stroke rehabilitation in patients experiencing loss of movement. It's so satisfying to see our devices used by so many in so many ways for so many diseases from cancers to mental disease to stroke to covid
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Why we should support it only if it's open source: A delightful new piece by @VitalikButerin (co-founder of Ethereum). https://t.co/DuD5eM9xw9 Full disclosure - Vitalik is a major supporter of Openwater - a fully open source medical device company with the makings of
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We have lots of contests now to win our new gear or internships or cash money. 100% open source (AGPL)... pathways to treat many cancers, mental diseases, cardio vascular diseases, neuro degenerative diseases and pathogenic disease like covid / long covid + longevity. Join
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