3/3 This insight could be useful for developing therapies for severely ill ME/CFS patients in future.

2/3Depolarization of skeletal muscle membrane by insufficient Na+/K+-ATPase activity, same cause as for mitochondrial dysfunction, leads to loss of force and worsens mitochondrial dysfunction even further.

1/3 Severely ill ME/CFS patients are the focus of Wirth & Steinacker’s new preprint. Strong loss of force, major cause of bedriddenness, is only partially explained by mitochondrial dysfunction. Evidence is provided for muscle depolarization as an additional aggravating mechanism

Huge thanks to Gez Medinger for this excellent work! https://t.co/5fE3o5kdCI

Die Arbeit im ⁦@BMG_Bund⁩ geht weiter, Wahlkampf ist nicht alles. Heute Gespräch mit Prof. Wirth von Mitodicure zu MDC002. Der Wirkstoff ist einer der wichtigen Hoffnungsträger für die Behandlung von #LongCovid. Ich unterstütze bei der Beschaffung von Risikokapital.

Review article by Carmen Scheibenbogen and Klaus Wirth, #mitodicure, shows that #MECFS is an Acquired Mitochondrial Myopathy. Mitodicure is a startup which develops a breakthrough drug to correct the key pathomechanisms maintaining ME/CFS. #LongCovid #BMBF https://t.co/Aef9kWkFqe

#mitodicure launched its website: https://t.co/tuoSweU0pK We are the only #MECFS start-up company worldwide developing a novel targeted drug. Support innovative drug development aimed at healing ME/CFS, which is also the most severe form of #LongCovid. #BMBF #MECFSAwarenessDay