A new study in @AnnalsofIM found that participants with social risk factors at the time of SARS-CoV-2 infection had greater risk for subsequent long COVID than those without. Read more here:

Read more here: #HIVCare #AdvancedHIVDisease @EmilyHyle @KenFreedberg @MGBResearchNews.

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These findings from the multi-disciplinary team at MGH, EGPAF, and the WHO underscore the substantial clinical and economic benefits of ensuring the availability and implementation of the WHO-recommended AHD package of care globally.

Including CD4 testing to diagnose people with AHD is critical; strategies that included CD4 testing were preferred and would result in better clinical outcomes and be cost-effective.

In a simulated cohort of 80 000 people living with HIV initiating outpatient ART in Malawi, the total costs over 5 years would increase by $6.98M (compared with ART only) with the WHO-recommended AHD package.

The WHO-recommended AHD package would reduce deaths due to tuberculosis by 30%, cryptococcal meningitis by 25%, and serious bacterial infections by 38%.

In this time of reduced funding to support the critical mission of HIV care globally, this analysis provides strong new scientific evidence to support prioritizing AHD clinical care as very high value.

AHD is diagnosed in ~30%% of people presenting or re-presenting to clinical care in sub-Saharan Africa; it is critical to ensure access to high-quality AHD clinical care and rapid ART initiation that is life-saving.

Hyle et al. found that the WHO-recommended package for advanced HIV disease (AHD) would improve clinical outcomes and quality-adjusted life expectancy and be cost-effective in Malawi and is likely to be cost-effective in most high burden HIV settings.

Read here:

Although transmission risk during breastfeeding with an undetectable viral load was not zero, it was very low, supporting evolving US/WHO BF guidelines that recommend shared-decision making about infant feeding.

Dugdale et al. found that maternal HIV viral load was strongly correlated with infant transmission risk. These data support U=U in pregnancy/birth.

This will support her work on Cutting Out Stigma, which uses barbershop-based interventions to combat HIV stigma among Black men in the Southern U.S. @HMS_DICP.

Congratulations to MPEC Investigator Aima Ahonkhai on receiving the HMS Diversity Inclusion and Community Partnership Faculty Fellow Award.

@LancetGH @DTHF_SA @NeilanAnne @LindaGailBekker @ElzetteRousseau @aciaranello @AliRahmanAhmed @clareflanagan71

.@LancetGH @DTHF_SA @mgh_mpec @NeilanAnne @lindagailbekker @ElzetteRousseau @aciaranello @AliRahmanAhmed @ClareFlanagan71.

Adolescent girls & young women are disproportionately impacted by HIV in South Africa. @mgh_mpec investigators and @DTHF_SA & @YaleSPH collabs show long-acting cabotegravir for HIV #PrEP for AGYW could reduce infections & transmissions and could be cost-saving at $65/year.

STI testing in hair salons in South Africa reaches women with risk factors for STIs and HIV, appears acceptable and feasible, and reveals a high STI prevalence @jjarolimova @HarvardCFAR @mgh_id

@mgh_id @aciaranello.

In a new modeling study, MPEC researchers found that anti-HIV broadly neutralizing antibodies (bNAbs) could prevent up to 42% of new pediatric HIV infections and be cost-effective for all infants born in high (>15%) HIV prevalence settings akin to a vaccine.